Mireille Serlie, MD, PhD
she/her/hers
Professor of Internal Medicine (Endocrinology)Cards
About
Research
Publications
2026
Sex disparities in patients undergoing metabolic bariatric surgery: Data from a national registry
van der Meer R, Monpellier VM, Liem RS, Janssen IM, Hazebroek EJ, Serlie MJ. Sex disparities in patients undergoing metabolic bariatric surgery: Data from a national registry. Clinical Nutrition 2026, 59: 106609. DOI: 10.1016/j.clnu.2026.106609.Peer-Reviewed Original ResearchSex disparities in patients undergoing metabolic bariatric surgery: Data from a national registry
van der Meer R, Monpellier V, Liem R, Janssen I, Hazebroek E, Serlie M. Sex disparities in patients undergoing metabolic bariatric surgery: Data from a national registry. Clinical Nutrition 2026, 59: 106609. PMID: 41825202, DOI: 10.1016/j.clnu.2026.106609.Peer-Reviewed Original ResearchConceptsMetabolic bariatric surgeryPostmenopausal womenPremenopausal womenBariatric surgeryPrimary laparoscopic Roux-en-Y gastric bypassLaparoscopic Roux-en-Y gastric bypassBody compositionRoux-en-Y gastric bypassTotal weight lossNational registryPre-surgery BMIObesity related comorbiditiesPostoperative bleeding rateUnfavorable body compositionUndertreatment of patientsSex disparitiesDisease burdenMonths post-surgeryWeight loss outcomesFollow-up dataRates of type 2 diabetesSignificant disease burdenType 2 diabetesComplication rateMenopausal statusCorrigendum to “The effect of preprandial versus postprandial physical activity on glycaemia: Meta-analysis of human intervention studies”. [Diabetes Res. Clin. Pract. 210 (2024) 111638]
Slebe R, Wenker E, Schoonmade L, Bouman E, Blondin D, Campbell D, Carpentier A, Hoeks J, Raina P, Schrauwen P, Serlie M, Stenvers D, de Mutsert R, Beulens J, Rutters F. Corrigendum to “The effect of preprandial versus postprandial physical activity on glycaemia: Meta-analysis of human intervention studies”. [Diabetes Res. Clin. Pract. 210 (2024) 111638]. Diabetes Research And Clinical Practice 2026, 233: 113143. PMID: 41688260, DOI: 10.1016/j.diabres.2026.113143.Peer-Reviewed Original Research
2025
Effectiveness of protein supplementation combined with resistance training to counteract disproportional fat-free mass loss following metabolic bariatric surgery: rationale and design of the ENRICHED randomised controlled trial
de Roos B, Yeh L, van den Hooff P, Nuijten M, Twisk J, Liem R, van Acker G, Severens J, Kambic T, Serlie M, Monpellier V, Eijsvogels T, Hopman M, Karregat J. Effectiveness of protein supplementation combined with resistance training to counteract disproportional fat-free mass loss following metabolic bariatric surgery: rationale and design of the ENRICHED randomised controlled trial. BMJ Open 2025, 15: e108346. PMID: 41469063, PMCID: PMC12750799, DOI: 10.1136/bmjopen-2025-108346.Peer-Reviewed Original ResearchConceptsResistance trainingHealth-related qualityFat-free mass lossRandomised controlled trialsFat-free massCare programmesMetabolic bariatric surgeryHealth-related quality of lifeInsufficient physical activityOne-repetition maximumResistance exercise trainingControlled TrialsPatient-tailored interventionsWhole-body RTAdverse health outcomesQuality of lifePeer-reviewed publicationsIncrease of fat-free massBariatric surgeryCardiorespiratory fitnessOne-repetitionPhysical activityExercise trainingMuscle strengthIntervention groupChallenges of nutritional support in patients with diabetes: A position paper of the ESPEN special interest group
Genton L, Sanz M, Arvanitakis M, Ballesteros-Pomar M, Bally L, Barazzoni R, Bétry C, Burgos R, Cuerda C, Hadefi A, Klek S, Mahmutovic M, Quilliot D, Rubin D, Schneider S, Serlie M, Collet T. Challenges of nutritional support in patients with diabetes: A position paper of the ESPEN special interest group. Clinical Nutrition 2025, 56: 106550. PMID: 41483482, DOI: 10.1016/j.clnu.2025.106550.Peer-Reviewed Original ResearchConceptsNutritional careSpecial Interest GroupSystematic searchManagement of blood glucose controlHealth care providersNutritional supportOptimal nutritional carePrevalence of diabetesPractice managementCare providersOral nutritional supplementsHealthcare providersAssociation of malnutritionStress hyperglycaemiaOlder peopleHospital foodAmbulatory settingDiabetes managementGeneral populationPharmacological treatmentDiabetes technologyPolymorbid conditionsPublished guidelinesModality of nutritional supportBlood glucose controlAltered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue.
Strober J, Ter Horst K, Sung D, Jongejan A, Slusher A, Gassaway B, Tarabra E, Paulo J, Shuken S, Gygi S, Santoro N, Caprio S, Serlie M, Bogan J, Vatner D. Altered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue. Diabetes 2025, 75: 341-350. PMID: 41347935, PMCID: PMC12823340, DOI: 10.2337/db25-0488.Peer-Reviewed Original ResearchWhite adipose tissueInsulin signalingUBX domainGLUT4 vesiclesSubcutaneous white adipose tissueMolecular regulationInsulin-responsive tissuesExpression of multiple componentsHuman white adipose tissueRegulatory signaling pathwaysGLUT4 translocationAdipose tissueProteomic dataRNA sequencingHuman IRInsulin resistanceSignaling pathwayGLUT4Intracellular poolUbxGlucose uptakeGLUT4 contentQuantitative PCRPathwayBariatric surgery cohortThe GLP-1R Agonist Semaglutide Reduces Motivated Running and Alters Dopamine Dynamics in the Nucleus Accumbens.
Foscue EP, Trinko JR, Jiménez JL, Kong E, Thompson SL, Stankewich K, Corstens AM, Serlie MJ, Taylor JR, DiLeone RJ. The GLP-1R Agonist Semaglutide Reduces Motivated Running and Alters Dopamine Dynamics in the Nucleus Accumbens. BioRxiv 2025 PMID: 41279988, DOI: 10.1101/2025.10.08.681212.Peer-Reviewed Original ResearchPrevalence of osteoporosis in adult patients on home parenteral nutrition
van der Werf M, Swarts J, Serlie M, Bisschop P. Prevalence of osteoporosis in adult patients on home parenteral nutrition. Clinical Nutrition ESPEN 2025, 69: 1107. DOI: 10.1016/j.clnesp.2025.07.892.Peer-Reviewed Original ResearchThe Acute Effects of Morning Bright Light on the Human White Adipose Tissue Transcriptome: Exploratory Post Hoc Analysis
Wang A, Vreijling J, Jongejan A, Rumanova V, Versteeg R, Kalsbeek A, Serlie M, la Fleur S, Bisschop P, Baas F, Stenvers D. The Acute Effects of Morning Bright Light on the Human White Adipose Tissue Transcriptome: Exploratory Post Hoc Analysis. Clocks & Sleep 2025, 7: 45. PMID: 40981208, PMCID: PMC12452623, DOI: 10.3390/clockssleep7030045.Peer-Reviewed Original ResearchWhite adipose tissue transcriptomeWhite adipose tissueBright light exposureSuprachiasmatic nucleusHealthy menAcute effectsType 2 diabetes mellitusGroup differencesHealthy lean subjectsRandomized cross-over trialCentral brain clockExploratory post hoc analysisCross-over trialPost Hoc AnalysisWhite adipose tissue biopsiesLean subjectsMorning bright lightExcess white adipose tissueRisk factorsHoc AnalysisAdipose tissue transcriptomeDM2Endocrine organAdipose tissueObesityInternational expert consensus on surgery for type 2 diabetes mellitus
Kermansaravi M, Omar I, Finer N, Le Roux C, Carbajo M, Sarwer D, Busetto L, Ponce J, Logue J, Parretti H, O’Kane M, Shahabi S, Khunti K, Blakemore A, Stenberg E, Abbott S, Alqahtani A, Aminian A, Amr B, Balibrea J, Batterham R, Behrens E, Bhatt D, Chesworth P, Chowbey P, Clare K, Neto M, Graham Y, Goel R, Hanif W, Herrera M, Kasama K, Kassir R, Knop F, Kothari S, Kristinsson J, McGowan B, McKechnie A, Miller K, Miras A, Morton J, Ogden J, Peterli R, Pinkney J, Pournaras D, Pouwels S, Prager G, Salminen P, Serlie M, Shabbir A, Singhal R, Taheri S, Tahrani A, Weiner R, Shikora S, Mahawar K. International expert consensus on surgery for type 2 diabetes mellitus. BMC Endocrine Disorders 2025, 25: 151. PMID: 40598146, PMCID: PMC12211331, DOI: 10.1186/s12902-025-01961-w.Peer-Reviewed Original ResearchConceptsType 2 diabetes mellitusMetabolic surgeryEstablished treatment optionRemission of T2DMEvidence-based expert consensusExpert consensusExpert consensus statementRoutine clinical useGrading of recommendations assessmentInternational multidisciplinary expertsInternational expert consensusQuality of evidenceEvidence-based guidelinesMBS proceduresBariatric surgeryTreatment optionsPostoperative considerationsDelphi consensus processT2DM patientsSurgeryClinical useConsensus statementPersonalized treatmentRecommendations AssessmentT2DM
Academic Achievements & Community Involvement
News
News
- March 03, 2025
The Role of Diet in Managing Obesity
- November 27, 2024Source: Medscape
Eating More Red Meat Could Increase Type 2 Diabetes Risk
- April 16, 2024
New Professors in the Department of Internal Medicine
- March 20, 2024
How the Standard American Diet Affects Your Brain
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