Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsMary Daly
Clinical InstructorAbout
Research
Publications
2025
Profiling DNA damage response in ATM/BRCA2 carriers to inform hereditary cancer risk.
Dedousis D, Hasan A, Patel K, Czyzewicz P, Devarajan K, Hall M, Daly M, Arora S. Profiling DNA damage response in ATM/BRCA2 carriers to inform hereditary cancer risk. Journal Of Clinical Oncology 2025, 43: 10574-10574. DOI: 10.1200/jco.2025.43.16_suppl.10574.Peer-Reviewed Original ResearchGermline pathogenic variantsCancer-free controlsPeripheral blood monocytesSignificant cut-pointsCRC casesDNA damage responseCut-pointsHereditary cancer riskBenjamini-Hochberg false discovery rate methodTwo-sided Mann-Whitney testHigh-risk familiesSporadic colorectal cancerPreliminary analysis of patientsDiagnosis of cancerAnalysis of patientsHigh-risk populationFalse discovery rate methodCancer riskHigh-risk groupNegative regulator of p53Age-matched controlsDNA repair genesDamage responseMann-Whitney testNon-carrier controlsGirls with high hormonal steroids, BMI and stress reach puberty early
Houghton L, wei Y, Wudy S, hartmann M, stanczyk F, Knight J, andrulis I, Bradbury A, Schwartz L, Buys S, Daly M, John E, Chung W, santella R, Romeo R, Beth T. Girls with high hormonal steroids, BMI and stress reach puberty early. Endocrine Abstracts 2025 DOI: 10.1530/endoabs.110.p991.Peer-Reviewed Original ResearchDoes inclusion of neighborhood variables improve clinical risk prediction for advanced prostate cancer in Black and White men?
Tagai E, Handorf E, Sorice K, Fang C, Deng M, Daly M, Reese A, Henry K, Ragin C, Lynch S. Does inclusion of neighborhood variables improve clinical risk prediction for advanced prostate cancer in Black and White men? Urologic Oncology Seminars And Original Investigations 2025, 43: 334.e17-334.e24. PMID: 40121103, PMCID: PMC12068980, DOI: 10.1016/j.urolonc.2025.02.021.Peer-Reviewed Original ResearchConceptsNeighborhood-level variablesProstate Cancer Prevention TrialNeighborhood variablesProtective service occupationsBlack menNeighborhood-level risk factorsWhite menNeighborhood-level povertyMedical oncology clinicUniversity Health SystemCancer Prevention TrialRisk prediction toolsLogistic regression modelsRisk prediction modelSocial environmental variablesPatients' medical recordsService occupationsHigh-grade PCaCurrent risk prediction modelsHealth systemPersistent disparitiesOncology clinicInsurance statusAssociated with ratesClinical risk prediction
2024
Changes in Risk Tolerance for Ovarian Cancer Prevention Strategies during the COVID-19 Pandemic: Results of a Discrete Choice Experiment
Egleston B, Daly M, Lew K, Bealin L, Husband A, Stopfer J, Przybysz P, Tchuvatkina O, Wong Y, Garber J, Rebbeck T. Changes in Risk Tolerance for Ovarian Cancer Prevention Strategies during the COVID-19 Pandemic: Results of a Discrete Choice Experiment. Medical Decision Making 2024, 45: 168-176. PMID: 39722532, PMCID: PMC11881031, DOI: 10.1177/0272989x241302829.Peer-Reviewed Original ResearchConceptsHigher ovarian cancer riskRisk of ovarian cancerRisk-reducing surgeryOvarian cancer riskCancer prevention strategiesCancer riskPrevention strategiesOvarian cancerOvarian cancer prevention strategiesElevated risk of breastRisk of breastCOVID-19 pandemicPrevention scenariosInfluence patients' decisionsRisk-reducing strategiesMedical decision makingAge of menopauseDiscrete choice experimentPatient's decisionElevated riskGenetic testingCOVID-19Menopausal symptomsMedical CenterHeart diseaseEfficacy of a couple‐based intervention addressing sexual concerns for breast cancer survivors: Results of a randomized controlled trial
Reese J, Lepore S, Sorice K, Zimmaro L, Hasler J, Handorf E, Daly M, Zaleta A, Westbrook K, Porter L. Efficacy of a couple‐based intervention addressing sexual concerns for breast cancer survivors: Results of a randomized controlled trial. Cancer 2024, 131: e35685. PMID: 39645589, PMCID: PMC11696781, DOI: 10.1002/cncr.35685.Peer-Reviewed Original ResearchBreast cancer survivorsCouple-based interventionsActive control interventionCancer survivorsSexual concernsRandomized Controlled TrialsIE interventionIntervention effectsIntimacy enhancementEstimates of intervention effectsMixed linear regression modelsSexual functionSurvivors 3 monthsLinear regression modelsLive HealthyFour-sessionIE sessionControl interventionsSecondary outcomesInterventionSatisfaction rateShort-term benefitsSexual adjustmentSurvivorsOverall sexual functionMenopausal hormone therapy: assessing associations with breast and colorectal cancers by familial risk
Macinnis R, Jenkins M, Milne R, John E, Daly M, Andrulis I, Colonna S, Phillips K, Investigators K, Le Marchand L, Newcomb P, Phipps A, Schmit S, Macrae F, Buchanan D, Gallinger S, Pai R, Samadder N, Giles G, Southey M, Hopper J, Terry M. Menopausal hormone therapy: assessing associations with breast and colorectal cancers by familial risk. JNCI Cancer Spectrum 2024, 9: pkae121. PMID: 39673461, PMCID: PMC11700558, DOI: 10.1093/jncics/pkae121.Peer-Reviewed Original ResearchFamily risk scoreMenopausal hormone therapyFamilial riskHazard ratioColorectal cancerFamilial risk of BCBreast cancerFamily historyDecreased colorectal cancerCancer family historyRisk of BCIncreased breast cancerAssociated with breastIncident BCNever usersGeneral populationRisk scoreHarmonized dataWomenHormone therapyRiskAssociationCancerNeverCohortPhysical activity during adolescence and early adulthood and breast cancer risk before age 40 years
Kehm R, Genkinger J, Knight J, MacInnis R, Liao Y, Li S, Weideman P, Chung W, Kurian A, Colonna S, Andrulis I, Buys S, Daly M, John E, Hopper J, Terry M. Physical activity during adolescence and early adulthood and breast cancer risk before age 40 years. Cancer Epidemiology Biomarkers & Prevention 2024, 34: 108-116. PMID: 39404779, PMCID: PMC11712034, DOI: 10.1158/1055-9965.epi-24-0743.Peer-Reviewed Original ResearchRecreational physical activityPhysical activityStrenuous recreational physical activityAssociated with BC riskBreast cancerBreast cancer riskBC risk factorsEarly adulthoodCox proportional hazards regression modelsProportional hazards regression modelsHazards regression modelsBC riskCancer riskLowest quartileFamily cohortStudy enrollmentRisk factorsRegression modelsYoung womenStudy centersWomenAdolescentsAgeCohortAdulthoodHormonal Contraception and Breast Cancer Risk for Carriers of Germline Mutations in BRCA1 and BRCA2
Phillips K, Kotsopoulos J, Domchek S, Terry M, Chamberlain J, Bassett J, Aeilts A, Andrulis I, Buys S, Cui W, Daly M, Eisen A, Foulkes W, Friedlander M, Gronwald J, Hopper J, John E, Karlan B, Kim R, Kurian A, Lubinski J, Metcalfe K, Nathanson K, Singer C, Southey M, Symecko H, Tung N, Narod S, Milne R, the Risk Factor Analysis of Hereditary Breast and Ovarian Cancer Study T, Study T, Amor D, Andrews L, Antill Y, Balleine R, Beesley J, Bennett I, Bogwitz M, Bodek S, Botes L, Brennan M, Brown M, Buckley M, Burke J, Butow P, Caldon L, Campbell I, Cao M, Chakrabarti A, Chauhan D, Chauhan M, Chenevix-Trench G, Christian A, Cohen P, Colley A, Crook A, Cui J, Courtney E, Cummings M, Dawson S, DeFazio A, Delatycki M, Dickson R, Dixon J, Edwards S, Farshid G, Fellows A, Fenton G, Field M, Flanagan J, Fong P, Forrest L, Fox S, French J, Friedlander M, Gaff C, Gattas M, George P, Greening S, Harris M, Hart S, Harraka P, Hayward N, Hopper J, Hoskins C, Hunt C, James P, Jenkins M, Kidd A, Kirk J, Koehler J, Kollias J, Lakhani S, Lawrence M, Lee J, Li S, Lindeman G, Lippey J, Lipton L, Lobb L, Loi S, Mann G, Marsh D, McLachlan S, Meiser B, Milne R, Nightingale S, O'Connell S, O'Sullivan S, Ortega D, Pachter N, Pang J, Pathak G, Patterson B, Pearn A, Phillips K, Pieper E, Ramus S, Rickard E, Ragunathan A, Robinson B, Saleh M, Skandarajah A, Salisbury E, Saunders C, Saunus J, Savas P, Scott R, Scott C, Sexton A, Shaw J, Shelling A, Srinivasa S, Simpson P, Southey M, Spurdle A, Taylor J, Taylor R, Thorne H, Trainer A, Tucker K, Visvader J, Walker L, Williams R, Winship I, Young M, Zaheed M. Hormonal Contraception and Breast Cancer Risk for Carriers of Germline Mutations in BRCA1 and BRCA2. Journal Of Clinical Oncology 2024, 43: 422-431. PMID: 39356978, PMCID: PMC11771360, DOI: 10.1200/jco.24.00176.Peer-Reviewed Original ResearchAssociated with increased BC riskBC riskHormonal contraceptionMutation carriersBreast cancerAssociated with BC riskCarriers of germline mutationsBreast cancer riskMedian Follow-UpAssociated with increased riskIncreased breast cancerHormonal contraceptive useProspective cohort studyGermline mutationsFollow-upCohort studyCox regressionCancer riskContraceptive useContraceptionCumulative durationMutationsRiskProportional increaseYearsUptake of Aspirin Chemoprevention in Patients With Lynch Syndrome
Singhal S, Riggs E, Ruth K, Chavez-Salas J, Chertock Y, Daly M, Hall M. Uptake of Aspirin Chemoprevention in Patients With Lynch Syndrome. JCO Precision Oncology 2024, 8: e2400562. PMID: 39546469, PMCID: PMC11573245, DOI: 10.1200/po-24-00562.Peer-Reviewed Original ResearchConceptsLynch syndromeLifetime risk of colorectal cancerColorectal cancerRisk of colorectal cancerCancer prevention optionsFactors associated with useNonsteroidal anti-inflammatory drugsDisease-related factorsChemoprevention uptakeScreening behaviorAspirin chemopreventionRelative risk reductionResearch invitationsPatients' perceptionsLifetime riskAdvocacy websitesASA/NSAID useElectronic surveyFox Chase Cancer CenterPrevention optionsCancer CenterRisk reductionMultivariate modelChemopreventive benefitsParticipantsPregnancy-Related Factors and Breast Cancer Risk for Women Across a Range of Familial Risk
McDonald J, Liao Y, Knight J, John E, Kurian A, Daly M, Buys S, Huang Y, Frost C, Andrulis I, Colonna S, Friedlander M, Hopper J, Chung W, Genkinger J, MacInnis R, Terry M, Amor D, Andrews L, Antill Y, Balleine R, Beesley J, Bennett I, Bogwitz M, Bodek S, Botes L, Brennan M, Brown M, Buckley M, Burke J, Butow P, Caldon L, Campbell I, Cao M, Chakrabarti A, Chauhan D, Chauhan M, Chenevix-Trench G, Christian A, Cohen P, Colley A, Crook A, Cui J, Courtney E, Cummings M, Dawson S, deFazio A, Delatycki M, Dickson R, Dixon J, Edwards S, Farshid G, Fellows A, Fenton G, Field M, Flanagan J, Fong P, Forrest L, Fox S, French J, Friedlander M, Gaff C, Gattas M, George P, Greening S, Harris M, Hart S, Harraka P, Hayward N, Hopper J, Hoskins C, Hunt C, James P, Jenkins M, Kidd A, Kirk J, Koehler J, Kollias J, Lakhani S, Lawrence M, Lee J, Li S, Lindeman G, Lippey J, Lipton L, Lobb L, Loi S, Mann G, Marsh D, McLachlan S, Meiser B, Milne R, Nightingale S, O'Connell S, O'Sullivan S, Gallego Ortega D, Pachter N, Pang J, Pathak G, Patterson B, Pearn A, Phillips K, Pieper E, Ramus S, Rickard E, Ragunathan A, Robinson B, Saleh M, Skandarajah A, Salisbury E, Saunders C, Saunus J, Savas P, Scott R, Scott C, Sexton A, Shaw J, Shelling A, Srinivasa S, Simpson P, Southey M, Spurdle A, Taylor J, Taylor R, Thorne H, Trainer A, Tucker K, Visvader J, Walker L, Williams R, Winship I, Young M, Zaheed M. Pregnancy-Related Factors and Breast Cancer Risk for Women Across a Range of Familial Risk. JAMA Network Open 2024, 7: e2427441. PMID: 39186276, DOI: 10.1001/jamanetworkopen.2024.27441.Peer-Reviewed Original ResearchConceptsPregnancy-related factorsFull-term pregnancyBC riskNulliparous womenProspective Family Study CohortBreast Cancer Family RegistryBreast cancerBC diagnosisER-negative BCCohort studyHazard ratioCancer Family RegistryBreast cancer riskPersonal history of BCBC family historyCohort study of womenHistory of BCCohort of womenCox proportional hazards regression modelsProportional hazards regression modelsStudy of womenER-negative diseaseFamily RegistryHazards regression modelsScreening guidelines
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