Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsMargaret Hostetter
Professor AdjunctAbout
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Titles
Professor Adjunct
Physician-in-Chief, Yale-New Haven Children's Hospital; Chair, Department of Pediatrics; Section Chief, Pediatric Immunology
Biography
Director of the Yale Child Health Research Center since 1998 and Chair of Yale's Department of Pediatrics since 2002, Hostetter is a specialist in pediatric infectious diseases and in the evaluation of internationally adopted children. Her studies of Streptococcus pneumoniae, a leading global respiratory pathogen, and Candida albicans, a yeast that infects immunocompromised patients, have been supported by the NIH and private foundations for more than 25 years. She and members of her laboratory hold five patents for discoveries in these areas.
She also serves as program director of the Pediatric Scientist Development Program, a multi-million dollar training program for pediatric physician-scientists funded by the National Institute of Child Health and Human Development. Prior to coming to Yale, Hostetter held the American Legion Heart Research Chair in Pediatrics at the University of Minnesota and headed the Division of Pediatric Infectious Diseases.Hostetter's honors include the American Academy of Pediatrics Award for Excellence in Research, the Samuel Rosenthal Award for contributions to academic pediatrics, and the E. Mead Johnson Award for Pediatric Research from the Society for Pediatric Research (SPR). She is a member of the Institute of Medicine of the National Academy of Sciences.
She also serves as program director of the Pediatric Scientist Development Program, a multi-million dollar training program for pediatric physician-scientists funded by the National Institute of Child Health and Human Development. Prior to coming to Yale, Hostetter held the American Legion Heart Research Chair in Pediatrics at the University of Minnesota and headed the Division of Pediatric Infectious Diseases.Hostetter's honors include the American Academy of Pediatrics Award for Excellence in Research, the Samuel Rosenthal Award for contributions to academic pediatrics, and the E. Mead Johnson Award for Pediatric Research from the Society for Pediatric Research (SPR). She is a member of the Institute of Medicine of the National Academy of Sciences.
Last Updated on June 18, 2015.
Departments & Organizations
- Pediatrics
- Yale Child Health Research Center
Education & Training
- Fellow
- Boston Children's, Harvard (1980)
- Intern & Resident
- Boston Children's Hospital, Harvard (1978)
Research
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Overview
Among the fungi, the yeast Candida albicans is the leading cause of death in susceptible hosts including premature newborns, patients with cancer, and other immunocompromised patients. Expanding upon our prior characterization of functions of the Int1 protein in adhesion and filamentous growth (Science 279:1355-8, 1998), we have defined new roles for this protein in superantigen-mediated injury, heparin binding, and biofilm formation. Other projects in the laboratory focus on the involvement of the mitochondrial proteome in C. albicans morphogenesis and on the mechanisms whereby this yeast invades the human gastrointestinal tract. In vitro models of gastrointestinal invasion are particularly interesting because of the novel linkage between C. albicans proteases, epithelial E-cadherin, and signaling via the gamma-secretase pathway.
- How heparin enhances the ability of Candida albicans to evade innate immunity
- Statins as inhibitors of Candida albicans biofilm
- High throughput screening to identify other inhibitors of C. albicans biofilm
ORCID
0000-0002-5012-1682
Research at a Glance
Yale Co-Authors
Frequent collaborators of Margaret Hostetter's published research.
Publications Timeline
A big-picture view of Margaret Hostetter's research output by year.
Pnina Weiss, MD, MHPE
Richard A Martinello, MD
128Publications
5,077Citations
Publications
2024
Complete Blood Count Values Over Time in Young Children During the Dengue Virus Epidemic in the Dominican Republic From 2018 to 2020
Day M, Puello Y, Sang M, Brockmans E, Soto M, Defilló S, Cruz K, Pérez J, Meña R, Mota C, Hostetter M, Muglia L, del Rey J, Schlaudecker E, Martin L, Simpson B, Prada C. Complete Blood Count Values Over Time in Young Children During the Dengue Virus Epidemic in the Dominican Republic From 2018 to 2020. BioMed Research International 2024, 2024: 3716786. PMID: 39130533, PMCID: PMC11316910, DOI: 10.1155/2024/3716786.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsComplete blood countDF severityConclusions:Severe DFComplete blood count valuesDengue feverAssociated with thrombocytopeniaDays of feverPeripheral blood studiesBlood count valuesLaboratory trendsRisk-stratified screeningDF positivityResource-limited settingsClinical symptom changeDR cohortLow-resource settingsPediatric patientsPlatelet countClinical characteristicsLaboratory findingsBlood countDengue virus epidemicsFever daysDay 1
2022
The 2019–2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children
Simpson B, Mejía Sang M, Collado Puello Y, Diaz Brockmans E, Díaz Soto M, Rivera Defilló S, Taveras Cruz K, Santiago Pérez J, Husami A, Day M, Pilipenko V, Mena R, Mota C, Hostetter M, Muglia L, Schlaudecker E, Gonzalez Del Rey J, Martin L, Prada C. The 2019–2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children. Journal Of The Pediatric Infectious Diseases Society 2022, 12: 169-172. PMID: 36537278, DOI: 10.1093/jpids/piac136.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2021
Physician-Scientist Training and Programming in Pediatric Residency Programs: A National Survey
Burns AM, Moore DJ, Forster CS, Powell W, Thammasitboon S, Hostetter MK, Weiss P, Boyer D, Ward MA, Blankenburg R, Heyman MB, Rassbach CE, McPhillips H, French A, Nguyen S, Byrne BJ, Parsons DW, Gonzalez F, Nowalk AJ, Ho J, Kumar S, Orange JS, Ackerman KG. Physician-Scientist Training and Programming in Pediatric Residency Programs: A National Survey. The Journal Of Pediatrics 2021, 241: 5-9.e3. PMID: 34280401, DOI: 10.1016/j.jpeds.2021.07.014.Peer-Reviewed Original ResearchCitationsAltmetricAcademic pipeline initiatives in pediatrics
Gordon C, Hostetter M, DeBaun M. Academic pipeline initiatives in pediatrics. Pediatric Research 2021, 92: 1520-1526. PMID: 34103680, DOI: 10.1038/s41390-021-01615-2.Peer-Reviewed Original ResearchCitationsMeSH KeywordsPerspectives from the Society for Pediatric Research: advice on sustaining science and mentoring during COVID-19
Forster CS, Nguyen ST, Powell WT, Moore DJ, Ho J, Heyman MB, Wenger TL, Gonzalez F, Hostetter M, Nowalk A, Rassbach CE, Boyer D, Weiss P, Blankenburg RL, Orange JS, Ackerman KG, Burns AM. Perspectives from the Society for Pediatric Research: advice on sustaining science and mentoring during COVID-19. Pediatric Research 2021, 90: 738-743. PMID: 33469179, PMCID: PMC7814517, DOI: 10.1038/s41390-020-01321-5.Peer-Reviewed Original ResearchCitationsAltmetric
2020
The Impact of Primary Mentors and Career Development Committees on Junior Faculty Productivity in a Pediatric Academic Health Center
Hackworth J, Meinzen-Derr J, DePalma M, Hostetter M, Klein M, O'Toole J, Kahn J. The Impact of Primary Mentors and Career Development Committees on Junior Faculty Productivity in a Pediatric Academic Health Center. The Journal Of Pediatrics 2020, 232: 4-8.e1. PMID: 33091419, DOI: 10.1016/j.jpeds.2020.10.037.Peer-Reviewed Original ResearchCitationsAltmetricAddressing Gaps in Pediatric Scientist Development: The Department Chair View of 2 AMSPDC-Sponsored Programs
Barrett K, Cooley T, Schwartz A, Hostetter M, Clapp D, Permar S. Addressing Gaps in Pediatric Scientist Development: The Department Chair View of 2 AMSPDC-Sponsored Programs. The Journal Of Pediatrics 2020, 222: 7-12.e4. PMID: 32586535, PMCID: PMC8852247, DOI: 10.1016/j.jpeds.2020.01.054.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsDevelopment of a Pediatric Education Research Unit
Klein M, Real F, Kachelmeyer A, del Rey J, DeWitt T, Hostetter M, Schumacher D. Development of a Pediatric Education Research Unit. The Journal Of Pediatrics 2020, 220: 4-6.e1. PMID: 32334671, DOI: 10.1016/j.jpeds.2019.12.007.Peer-Reviewed Original ResearchCitationsAltmetricFixing the leaky pipeline: identifying solutions for improving pediatrician-scientist training during pediatric residency
Burns AM, Ackerman KG, Thammasitboon S, Rassbach CE, Ward MA, Blankenburg RL, Forster CS, McPhillips HA, Wenger TL, Powell WT, Heyman MB, Hogarty MD, Boyer D, Hostetter M, Weiss P, Nguyen ST, Parsons DW, Moore DJ, Byrne BJ, French AR, Orange JS. Fixing the leaky pipeline: identifying solutions for improving pediatrician-scientist training during pediatric residency. Pediatric Research 2020, 88: 163-167. PMID: 32179872, DOI: 10.1038/s41390-020-0837-2.Peer-Reviewed Original ResearchCitationsAltmetricEnsuring Equity in Compensation and Career Advancement for Female Physicians
Hostetter M. Ensuring Equity in Compensation and Career Advancement for Female Physicians. Mayo Clinic Proceedings 2020, 95: 3-5. PMID: 31902425, DOI: 10.1016/j.mayocp.2019.11.003.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords
Academic Achievements & Community Involvement
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Activities
activity National Institutes of Health
2008 - 2011Peer Review Groups and Grant Study SectionsMemberDetailsHIBP study sectionactivity March of Dimes
1994 - 2009Peer Review Groups and Grant Study SectionsMemberDetailsGrant review panelsactivity Yale School of Medicine
2002 - 2009CommitteesMemberDetailsSearch committees for Chairs of Internal Medicine, Cancer Center, Epidemiology and Public Health, Psychiatryactivity Yale University
2006 - 2008CommitteesMemberDetailsProvost's Committee on Financesactivity NICHD
1999 - 2004CommitteesMemberDetailsNICHD Council
Honors
honor Appointment to the NIH Director’s Blue Ribbon Panel on Clinical Research
01/01/2003UnknownDetailsUnited Stateshonor Maxwell Finland Lecturer
01/01/2001UnknownInfectious Diseases Society of AmericaDetailsUnited Stateshonor Election to the Institute of Medicine
01/01/2001UnknownNational Academy of SciencesDetailsUnited Stateshonor E. Mead Johnson Award for Pediatric Research
01/01/1995National AwardSociety for Pediatric ResearchDetailsUnited Stateshonor Samuel Rosenthal Foundation Award for Outstanding Contributions to Academic Pediatrics
01/01/1995National AwardSamuel Rosenthal FoundationDetailsUnited States
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- May 22, 2023
Retrospective
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