Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsLokesh Kumar Sharma, PhD
Assistant Professor AdjunctAbout
Research
Publications
2025
IL‐6 signaling regulates the inflammatory response without impacting pathogen burden during influenza‐associated pulmonary aspergillosis
Sharma L, Singh R, Tolman N, Ngeow C, Duray A, Naghshtabrizi N, Ahmad A, Bain W, Robinson K. IL‐6 signaling regulates the inflammatory response without impacting pathogen burden during influenza‐associated pulmonary aspergillosis. Physiological Reports 2025, 13: e70372. PMID: 40420617, PMCID: PMC12106949, DOI: 10.14814/phy2.70372.Peer-Reviewed Original ResearchConceptsAF infectionAspergillus fumigatusInterleukin-6IL-6 signalingLung inflammationInfluenza-associated pulmonary aspergillosisInterleukin-6 knockout miceNeutrophilic lung inflammationBronchoalveolar lavage fluidEpithelial cell damageLung capillary permeabilitySusceptibility to opportunistic pathogensPulmonary aspergillosisClinical courseLavage fluidKnockout miceOpportunistic pathogenRAGE levelsEpithelial integrityMouse modelIL-6Pathological inflammationTissue injuryInflammatory responseViral infectionProphylactic anticoagulant therapy is associated with improved survival in ICU patients with non-COVID-19 pneumonia: a retrospective cohort study
Hu H, Zhu Y, Hu R, Zhao L, Zeng X, Wu X, Qiu R, Nie Y, Sharma L, Chang D. Prophylactic anticoagulant therapy is associated with improved survival in ICU patients with non-COVID-19 pneumonia: a retrospective cohort study. Frontiers In Pharmacology 2025, 16: 1597885. PMID: 40406481, PMCID: PMC12095157, DOI: 10.3389/fphar.2025.1597885.Peer-Reviewed Original ResearchProphylactic anticoagulant therapyShort-term mortalityKaplan-Meier survival analysisAnticoagulant therapyICU patientsPropensity score matchingPulmonary infectionImproved survivalNon-COVID-19Subgroup analysisNon-COVID-19 pneumoniaDuration of anticoagulant therapyAssociated with improved survivalMultivariate Cox regression modelSurvival analysisEffect of anticoagulant therapyMedical Information Mart for Intensive Care IV databaseCox regression analysisRetrospective cohort studyAssociated with reduced short-term mortalityOptimal administration strategiesCox regression modelsPrognostic factorsAnticoagulation groupCoagulation disordersEpidermal Growth Factor Receptor Regulates Beclin-1 and Autophagy in Hyperoxic Acute Lung Injury
Harris Z, Korde A, Khoury J, Manning E, Stanley G, Sun Y, Hu B, Shin H, Joerns J, Clark B, Mitchell K, Placek L, Unutmaz D, Moldobaeva A, Sharma L, Sauler M, Rajagopalan G, Zhang X, Wang H, Ghaedi M, Kang M, Koff J. Epidermal Growth Factor Receptor Regulates Beclin-1 and Autophagy in Hyperoxic Acute Lung Injury. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a2472-a2472. DOI: 10.1164/ajrccm.2025.211.abstracts.a2472.Peer-Reviewed Original ResearchLower Respiratory Tract C. Albicans Induces Lung Injury in Mice and Associates With Lung Injury Endpoints in Humans
Tolman N, Choi W, Alder J, Tabary M, Qin S, Wang X, Zhang Y, Tu Y, Sharma L, Bon J, Robinson K, Snyder M, Dela Cruz C, Nguyen M, Morris A, Biswas P, Bain W, Kitsios G. Lower Respiratory Tract C. Albicans Induces Lung Injury in Mice and Associates With Lung Injury Endpoints in Humans. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a2825-a2825. DOI: 10.1164/ajrccm.2025.211.abstracts.a2825.Peer-Reviewed Original ResearchDichotomous Effects of TLR9 on Early Inflammation and Viral Clearance Dictates Recovery From Influenza Infection
Kim J, Yuan Y, Agaronyan K, Zhao A, Bain W, Evankovich J, Dela Cruz C, Ryu C, Sharma L. Dichotomous Effects of TLR9 on Early Inflammation and Viral Clearance Dictates Recovery From Influenza Infection. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a4707-a4707. DOI: 10.1164/ajrccm.2025.211.abstracts.a4707.Peer-Reviewed Original ResearchAcute Exacerbation of Interstitial Lung Disease Is Associated With Significantly Increased Mortality Compared to Acute Respiratory Distress Syndrome Despite Lower Systemic Inflammation
Deberry J, Kitsios G, Bain W, Sharma L, Dela Cruz C, Seedahmed M, Zhang Y, Kass D, Valenzi E, Mcverry B, Shah F. Acute Exacerbation of Interstitial Lung Disease Is Associated With Significantly Increased Mortality Compared to Acute Respiratory Distress Syndrome Despite Lower Systemic Inflammation. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a5653-a5653. DOI: 10.1164/ajrccm.2025.211.abstracts.a5653.Peer-Reviewed Original ResearchElectronic Cigarettes Exaggerate Influenza A Virus-induced Cell Death in Alveolar Epithelial Cells
Villandre J, Chandler M, Tuncer F, Tuncer B, Lear T, Sharma L, Chen B, Dela Cruz C, Evankovich J. Electronic Cigarettes Exaggerate Influenza A Virus-induced Cell Death in Alveolar Epithelial Cells. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a6602-a6602. DOI: 10.1164/ajrccm.2025.211.abstracts.a6602.Peer-Reviewed Original ResearchChitotriosidase in Influenza Lung Infection
Kim J, Amick A, Villandre J, Bain W, Evankovich J, Sharma L, Dela Cruz C. Chitotriosidase in Influenza Lung Infection. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7920-a7920. DOI: 10.1164/ajrccm.2025.211.abstracts.a7920.Peer-Reviewed Original ResearchIncretin Hormones Predict Response to Enteral Nutrition Dosing Strategies in Acute Respiratory Distress Syndrome
Hansell C, Yang Z, Yende S, Aneis H, Kitsios G, Bain W, Zhao Y, Sharma L, Petro N, Patel J, Mcverry B, Talisa V, Shah F. Incretin Hormones Predict Response to Enteral Nutrition Dosing Strategies in Acute Respiratory Distress Syndrome. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a1214-a1214. DOI: 10.1164/ajrccm.2025.211.abstracts.a1214.Peer-Reviewed Original ResearchGlucagon-Like Peptide-1 Is Prognostic of Mortality in Acute Respiratory Failure
Hansell C, Aneis H, Kitsios G, Bain W, Zhao Y, Suber T, Evankovich J, Sharma L, Ramakrishnan S, Prendergast N, Hensley M, Malik S, Petro N, Patel J, Nouraie S, Dela Cruz C, Zhang Y, McVerry B, Shah F. Glucagon-Like Peptide-1 Is Prognostic of Mortality in Acute Respiratory Failure. Critical Care Explorations 2025, 7: e1247. PMID: 40126931, PMCID: PMC11936568, DOI: 10.1097/cce.0000000000001247.Peer-Reviewed Original ResearchConceptsGlucose-dependent insulinotropic peptide levelsGlucagon-like peptide-1 levelsGlucose-dependent insulinotropic peptideAcute respiratory failureGlucagon-like peptide-1Respiratory failureIncretin levelsResponse biomarkersMeasure glucagon-like peptide-1Intestinal permeabilityPrognosticator of adverse outcomeSequential Organ Failure Assessment scoreCritical illnessOrgan Failure Assessment scorePeptide-1Acute respiratory distress syndromeAssociated with systemic inflammationMarkers of intestinal permeabilityCirculating interleukin-6 levelsHost response biomarkersSystemic host responseIncretin hormone glucagon-like peptide-1Respiratory distress syndromeInterleukin-6 levelsCritically ill patients