About
Titles
Program Manager
Departments & Organizations
- Maternal Fetal Medicine Unit
- Yale Hearts Moms (Lipkind Lab)
Research
Overview
Medical Research Interests
Diabetes, Gestational; Eclampsia; HELLP Syndrome; Hypertension, Pregnancy-Induced; Maternal Death; Maternal Mortality; Obstetric Labor Complications; Pre-Eclampsia; Pregnancy; Premature Birth; Stillbirth
Research at a Glance
Yale Co-Authors
Frequent collaborators of Lauren Perley's published research.
Publications Timeline
A big-picture view of Lauren Perley's research output by year.
Research Interests
Research topics Lauren Perley is interested in exploring.
Harvey Kliman, MD, PhD
Alla Vash-Margita, MD, FACOG
Carlos R Oliveira, MD, PhD
Olga Grechukhina, MD
Sangini S. Sheth, MD, MPH, FACOG
Anika K. Anam, MD
15Publications
114Citations
Pregnancy
Pre-Eclampsia
Hypertension, Pregnancy-Induced
Obstetric Labor Complications
Publications
2024
Longitudinal biomonitoring of mycotoxin exposure during pregnancy in the Yale pregnancy Outcome Prediction study
Krausová M, Ayeni K, Gu Y, Borutzki Y, O’Bryan J, Perley L, Silasi M, Wisgrill L, Johnson C, Warth B. Longitudinal biomonitoring of mycotoxin exposure during pregnancy in the Yale pregnancy Outcome Prediction study. Environment International 2024, 109081. DOI: 10.1016/j.envint.2024.109081.Peer-Reviewed Original ResearchConceptsPregnancy Outcome Prediction studyPregnant womenOutcome prediction studiesTandem mass spectrometryLiquid chromatography tandem mass spectrometryPlasma matrixUrine methodMass spectrometryUrinary dataHuman biomonitoringCarcinogen ochratoxin ASerum methodNeoplastic effectsSerumLC-MS/MSMonomethyl etherUnborn childSerum samplesTime pointsUrineBiomarkers of exposurePregnancyAdverse health effectsWomenHuman biomonitoring guidance valuesNoninvasive single‐cell‐based prenatal genetic testing: A proof of concept clinical study
Bellair M, Amaral E, Ouren M, Roark C, Kim J, O'Connor A, Soriano A, Schindler M, Wapner R, Stone J, Tavella N, Merriam A, Perley L, Breman A, Beaudet A. Noninvasive single‐cell‐based prenatal genetic testing: A proof of concept clinical study. Prenatal Diagnosis 2024, 44: 304-316. PMID: 38411249, DOI: 10.1002/pd.6529.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsNoninvasive prenatal genetic testingLow-risk pregnanciesConcept clinical studyCopy number analysisPrenatal genetic testingNext-generation sequencingPlacental mosaicismMaternal bloodAneuploidy resultsMeasures of test performanceCK stainingCVS casesClinical studiesGenetic testingNucleated cellsTrophoblastRed cellsNumber analysisPregnancyBloodDeletions/duplicationsAneuploidyDeletionAmniocentesisCells
2023
Unindicated Cervical Cancer Screening in Adolescent Females Within a Large Healthcare System in the United States
Hosier H, Sheth S, Oliveira C, Perley L, Vash-Margita A. Unindicated Cervical Cancer Screening in Adolescent Females Within a Large Healthcare System in the United States. Obstetrical & Gynecological Survey 2023, 78: 470-472. DOI: 10.1097/ogx.0000000000001179.Commentaries, Editorials and LettersConceptsCervical cancer screeningIncidence rateUnindicated testsPatient-specific variablesCervical cancerCancer screeningHPV testingYale New Haven Health SystemCervical cancer screening testsAdolescent femalesEligible young womenRepeated cross-sectional studyWell-woman examinationsAtypical squamous cellsHealth system patientsCancer screening testsWomen ages 21Cross-sectional studyLow incidence rateLarge healthcare systemElectronic medical recordsEvidence-based strategiesSelf-reported raceGuideline adherenceHPV test
2022
Sex differences in early and term placenta are conserved in adult tissues
Olney K, Plaisier S, Phung T, Silasi M, Perley L, O’Bryan J, Ramirez L, Kliman H, Wilson M. Sex differences in early and term placenta are conserved in adult tissues. Biology Of Sex Differences 2022, 13: 74. PMID: 36550527, PMCID: PMC9773522, DOI: 10.1186/s13293-022-00470-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFirst trimester placentaLate first trimesterTerm placentaTrimester placentaFirst trimesterAdult tissuesGene expressionSex differencesLifelong health outcomesSex-differential gene expressionGenetic sexInnate immune responseFull-term placentaSex-linked genesInnate immune genesImmune responsePlacenta samplesHealth outcomesBrain tissuePlacentaGametologous genesDifferent timepointsSex chromosomesImmune genesSexX chromosome inactivation in the human placenta is patchy and distinct from adult tissues
Phung TN, Olney KC, Pinto BJ, Silasi M, Perley L, O'Bryan J, Kliman HJ, Wilson MA. X chromosome inactivation in the human placenta is patchy and distinct from adult tissues. Human Genetics And Genomics Advances 2022, 3: 100142. PMID: 36187227, PMCID: PMC9519611, DOI: 10.1016/j.xhgg.2022.100142.Peer-Reviewed Original ResearchInsulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity
Anam AK, Cooke KM, Dratver MB, O'Bryan JV, Perley LE, Guller SM, Hwang JJ, Taylor HS, Goedeke L, Kliman HJ, Vatner DF, Flannery CA. Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity. Molecular Metabolism 2022, 64: 101574. PMID: 35970449, PMCID: PMC9440306, DOI: 10.1016/j.molmet.2022.101574.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDe novo lipogenesisFetal adiposityFatty acid uptakeMaternal obesityObese womenNormal weightExcess adiposityVillous explantsInsulin receptorNewborns of mothersNormal-weight womenAcid uptakePlacental villous explantsTranscription factor SREBP-1Insulin-like growth factor 2Effect of insulinFatty acid oxidationPlacental triglyceridesPlacental responsesElevated triglyceridesMaternal hyperglycemiaWeight womenGrowth factor 2Diabetes riskPlacental metabolismX chromosome inactivation in the human placenta is patchy and distinct from adult tissues
Phung TN, Olney KC, Pinto BJ, Silasi M, Perley L, O’Bryan J, Kliman HJ, Wilson MA. X chromosome inactivation in the human placenta is patchy and distinct from adult tissues. Human Genetics And Genomics Advances 2022, 3: 100121. PMID: 35712697, PMCID: PMC9194956, DOI: 10.1016/j.xhgg.2022.100121.Peer-Reviewed Original ResearchCitationsAltmetricConceptsX-chromosome inactivationAdult tissuesChromosome inactivationX chromosomeX chromosome expressionTissue-specific mapsPaternal X chromosomeHuman adult tissuesChromosome expressionX inactivationAllele-specific approachesGenetic femalesLarge patchesChromosomesHuman placentaInactivationTissueGenesRNADNAObserved sex differencesExpressionPlacentaSeizing the Window of Opportunity Within 1 Year Postpartum: Early Cardiovascular Screening
Ackerman‐Banks C, Grechukhina O, Spatz E, Lundsberg L, Chou J, Smith G, Greenberg VR, Reddy UM, Xu X, O’Bryan J, Smith S, Perley L, Lipkind HS. Seizing the Window of Opportunity Within 1 Year Postpartum: Early Cardiovascular Screening. Journal Of The American Heart Association 2022, 11: e024443. PMID: 35411781, PMCID: PMC9238464, DOI: 10.1161/jaha.121.024443.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHDP groupBody mass indexChronic hypertensionMonths postpartumHypertension 6Metabolic syndromeMass indexYear postpartumFamily historyMedical conditionsNew diagnosisHigh low-density lipoprotein cholesterolLow-density lipoprotein cholesterolEffective primary prevention strategiesPreexisting medical conditionsProspective cohort studyCVD risk scoreUnderlying medical conditionsCardiovascular disease riskMultidisciplinary care modelMultivariable logistic regressionDevelopment of CVDFirst year postpartumPrimary prevention strategiesHypertensive disorders
2021
Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States
Hosier H, Sheth SS, Oliveira CR, Perley LE, Vash-Margita A. Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States. American Journal Of Obstetrics And Gynecology 2021, 225: 649.e1-649.e9. PMID: 34256029, PMCID: PMC8633062, DOI: 10.1016/j.ajog.2021.07.005.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCervical cancerLarge healthcare systemYears of ageIncidence rateScreening testAdolescent femalesHealthcare systemLarge multihospital health systemCervical cancer screening resultsNew cervical cancer casesCurrent consensus recommendationsHuman papillomavirus testingHuman papillomavirus vaccinationCervical cancer casesCervical cancer screeningMultihospital health systemCancer risk reductionScreening resultsPoisson regression analysisEvidence-based strategiesGuideline nonadherencePapillomavirus vaccinationCytology testingIntraepithelial lesionsProvider factors
2020
932: Maternal pre-pregnancy BMI and risk of preterm birth
Calix R, Silasi M, Lundsberg L, Partridge C, Perley L, Culhane J. 932: Maternal pre-pregnancy BMI and risk of preterm birth. American Journal Of Obstetrics And Gynecology 2020, 222: s577. DOI: 10.1016/j.ajog.2019.11.943.Peer-Reviewed Original Research
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