2024
PIWI-interacting RNAs: who, what, when, where, why, and how
Haase A, Ketting R, Lai E, van Rij R, Siomi M, Svoboda P, van Wolfswinkel J, Wu P. PIWI-interacting RNAs: who, what, when, where, why, and how. The EMBO Journal 2024, 1-5. PMID: 39327528, DOI: 10.1038/s44318-024-00253-8.Peer-Reviewed Original ResearchPIWI-interacting RNAsPiRNA biologySelfish genetic elementsAdult mammalian testisGerm cell biologyRegulate gene expressionPIWI proteinsMammalian testisGenetic elementsEvolutionary biologistsAntiviral defenseGene expressionCell biologyBiologyPIWIRNATestisGeneticistsBiologistsProteinGermPlanariaDefenseExpressionBiochemists
2023
piRNA generation is associated with the pioneer round of translation in stem cells
Parambil S, Li D, Zelko M, Poulet A, van Wolfswinkel J. piRNA generation is associated with the pioneer round of translation in stem cells. Nucleic Acids Research 2023, 52: 2590-2608. PMID: 38142432, PMCID: PMC10954484, DOI: 10.1093/nar/gkad1212.Peer-Reviewed Original ResearchSMEDWI-1Pioneer roundStem cellsPlanarian stem cellsStem cell maintenanceStem cell stateNon-coding transcriptsPiRNA pathwayPIWI proteinsTransposon repressionBiogenesis pathwayPiRNA generationGenomic integritySmall RNAsCell maintenanceSuch transcriptsCell statesCytoplasmic poolTranscriptsCell coloniesCell healthPiRNAsDynamic poolTranscriptomeCellsInsights in piRNA targeting rules
van Wolfswinkel J. Insights in piRNA targeting rules. Wiley Interdisciplinary Reviews - RNA 2023, 15: e1811. PMID: 37632327, PMCID: PMC10895071, DOI: 10.1002/wrna.1811.Peer-Reviewed Original ResearchPIWI-interacting RNAsTarget transcriptsProtein-RNA interactionsRNA-RNA interactionsPotential target transcriptsPIWI proteinsProtein-RNARNA interactionsSequence complementarityCells of animalsTranscriptionEffective downregulationStructural studiesProteinPIWITransposonGermlineStem cellsRNATargetCleavageDownregulationDefense
2021
PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation
Li D, Taylor D, van Wolfswinkel J. PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation. Cell Reports 2021, 37: 109776. PMID: 34610311, PMCID: PMC8532177, DOI: 10.1016/j.celrep.2021.109776.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsPIWI proteinsCell differentiationDefective cell differentiationLineage-specific genesSubset of transposonsAdult pluripotent stem cellsSomatic cell differentiationStem cell systemStem cell biologyPluripotent stem cellsTransposon derepressionAnimal germlineSpecific chromatinRegenerative animalsPlanarian neoblastsCell biologyTransposonStem cellsProteinDifferentiationIntricate interplayCell systemAddition causesTissue dysfunction
2014
Piwi and Potency: PIWI Proteins in Animal Stem Cells and Regeneration
van Wolfswinkel JC. Piwi and Potency: PIWI Proteins in Animal Stem Cells and Regeneration. Integrative And Comparative Biology 2014, 54: 700-713. PMID: 24948137, DOI: 10.1093/icb/icu084.Peer-Reviewed Original ResearchConceptsPIWI proteinsSomatic stem cellsStem cellsDifferent animal phylaGerm cell lineageStem cell systemAnimal stem cellsAnimal germlineGermline developmentAncestral roleAnimal phylaDiverse animalsCell lineagesDifferentiation potentialProteinGermlineCell systemCellsSuch cellsPiwiPiRNAsPhylaLineagesTransposonAvailable reveals