2017
Endothelial Cell Function and Dysfunction in Critically Ill Children
Pierce RW, Giuliano JS, Pober JS. Endothelial Cell Function and Dysfunction in Critically Ill Children. Pediatrics 2017, 140: e20170355. PMID: 28759412, PMCID: PMC9923607, DOI: 10.1542/peds.2017-0355.Peer-Reviewed Original ResearchConceptsEndothelial cellsCritical illnessIll childrenCritically Ill ChildrenImmune cell recruitmentBiology of ECsEndothelial cell functionBroad anatomic distributionEntire vascular systemPathologic responseAnatomic distributionClinical correlationMaintenance of homeostasisBlood flowCell recruitmentBlood fluiditySystemic homeostasisCell functionSegmental differencesEC functionVascular systemIllnessChildrenHomeostasisSpecific role
2016
A regional cohort study of the treatment of critically ill children with bronchiolitis
Carroll CL, Faustino EV, Pinto MG, Sala KA, Canarie MF, Li S, Giuliano JS, Consortium T. A regional cohort study of the treatment of critically ill children with bronchiolitis. Journal Of Asthma 2016, 53: 1006-1011. PMID: 27177013, DOI: 10.1080/02770903.2016.1180697.Peer-Reviewed Original ResearchConceptsRSV bronchiolitisChildren's HospitalMechanical ventilationIll childrenChest physiotherapyICU lengthCohort studyMedical CenterConnecticut Children's Medical CenterHigh-flow nasal cannulaYale-New Haven Children's HospitalRegional cohort studyInvasive mechanical ventilationLonger ICU lengthRetrospective cohort studyRisk of intubationMortality risk scoreIntrapulmonary percussive ventilationChildren's Medical CenterUse of therapiesIntensive care courseClinical characteristicsNasal cannulaHypertonic salineMore frequent use
2014
Angiopoietin-1, Angiopoietin-2 and Bicarbonate as Diagnostic Biomarkers in Children with Severe Sepsis
Wang K, Bhandari V, Giuliano JS, O′Hern C, Shattuck MD, Kirby M. Angiopoietin-1, Angiopoietin-2 and Bicarbonate as Diagnostic Biomarkers in Children with Severe Sepsis. PLOS ONE 2014, 9: e108461. PMID: 25255212, PMCID: PMC4178003, DOI: 10.1371/journal.pone.0108461.Peer-Reviewed Original ResearchConceptsPediatric intensive care unitSepsis severityAngiopoietin-2Angiopoietin-1Severe pediatric sepsisSeverity of sepsisIntensive care unitTime of admissionHigh mortality rateSevere sepsisPediatric sepsisCare unitAng-2Ill childrenClinical dataAng-1Mortality rateSepsisSingle biomarkerDiagnostic biomarkersBiomarkersSeverityPlasma samplesMultiple biomarkersChildren
2013
The SNAP index does not correlate with the State Behavioral Scale in intubated and sedated children
Thompson C, Shabanova V, Giuliano JS. The SNAP index does not correlate with the State Behavioral Scale in intubated and sedated children. Pediatric Anesthesia 2013, 23: 1174-1179. PMID: 24103039, PMCID: PMC3880626, DOI: 10.1111/pan.12258.Peer-Reviewed Original ResearchConceptsState Behavioral ScalePediatric intensive care unitSNAP indexSedation levelIll childrenIll pediatric patientsIntensive care unitLevel of sedationPediatric critical careBehavioral scalesIntravenous sedationPediatric patientsSNAP-IICare unitSBS scoresSubjective sedationBedside nursesSedated childrenCritical careObservational studySedationScoring toolInformed consentPatientsBrain activity