John Cahill, MD, PhD
Associate Professor of PsychiatryDownloadHi-Res Photo
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Appointments
Psychiatry
Primary
Additional Titles
Residency Program Director, Psychiatry
Deputy Medical Director, Connecticut Mental Health Center
Chief of Behavioral Health, Continuum of Care Inc., --
Contact Info
Appointments
Psychiatry
Primary
Additional Titles
Residency Program Director, Psychiatry
Deputy Medical Director, Connecticut Mental Health Center
Chief of Behavioral Health, Continuum of Care Inc., --
Contact Info
Appointments
Psychiatry
Primary
Additional Titles
Residency Program Director, Psychiatry
Deputy Medical Director, Connecticut Mental Health Center
Chief of Behavioral Health, Continuum of Care Inc., --
Contact Info
About
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Titles
Associate Professor of Psychiatry
Residency Program Director, Psychiatry; Deputy Medical Director, Connecticut Mental Health Center
Positions outside Yale
Chief of Behavioral Health, Continuum of Care Inc., --
Biography
Dr. Cahill serves as Residency Program Director for the Yale Department of Psychiatry. As Chief of Behavioral Health at Continuum of Care Inc. he helped build the first co-occurring disorders residential treatment center, community-engaged crisis response team (Elm City COMPASS) and crisis receiving center (REST) in Connecticut. He has been instrumental in the adaptation and promotion of the construct of 'deprescribing' in psychiatry: as a means to seek minimum-effective dosing of medications; to center the patient; to deepen a shared formulation; and to fully integrate psychodynamic and socio-cultural considerations.
John is interested in emerging severe mental illness; continuous quality improvement via multi-stakeholder driven Learning Health Systems and translational research approaches. He co-created and directs the HONE (Healthcare Outcomes Network & Education) software consortium for first episode psychosis care, implemented in dozens of clinics nationally.
He undertook medical school and PhD training in the UK and completed psychiatry residency and clinical research fellowships at Yale. He is board certified in Psychiatry, Addiction Medicine and Clinical Informatics.
Last Updated on February 06, 2026.
Appointments
Psychiatry
Associate Professor on TermPrimary
Other Departments & Organizations
- Division of Public Psychiatry Research
- Psychiatry
- Yale New Haven Health System
Education & Training
- PhD
- University of Huddersfield, Translational neuroscience (2018)
- Fellow in Psychotic Disorders/ Community Psychiatry
- Yale University/ Connecticut Mental Health Center (2015)
- Fellow in Advanced Psychopharmacology
- Yale University/ West Haven VA (2014)
- Resident in Psychiatry
- Yale University (2012)
- Internship
- Yale School of Medicine (2009)
- BMBS
- University of Nottingham (2005)
Board Certifications
Clinical Informatics
- Certification Organization
- AB of Preventive Medicine
- Original Certification Date
- 2024
Addiction Medicine (Preventive Medicine)
- Certification Organization
- AB of Preventive Medicine
- Original Certification Date
- 2019
Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of John Cahill's published research.
Publications Timeline
A big-picture view of John Cahill's research output by year.
Vinod H. Srihari, MD
Fangyong Li, MS, MPH
Maria Ferrara, MD
Walter S. Mathis, MD
Albert Powers, MD, PhD
Cenk Tek, MD
19Publications
357Citations
Publications
2025
Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis
Mukhtar H, Zhou D, Farina E, Saxena A, Cahill J, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshwan M, Mathalon D, Perkins D, Stone W, Cho Y, Powers A, Walker E, Woods S. Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis. Psychological Medicine 2025, 55: e241. PMID: 40842369, PMCID: PMC12404330, DOI: 10.1017/s0033291725101372.Peer-Reviewed Original ResearchCitationsAltmetricConceptsClinical high riskCHR-PLifetime historyAugmentation of antidepressant treatmentComorbid major depressionAP useAntidepressant treatmentPositive symptomsMajor depressionAP medicationNAPLS-2Independent predictorsCHR-P.High riskBaseline clinical variablesPsychosisBaseline predictorsClinical variablesParticipantsBaseline characteristicsUnivariate analysisLogistic regression modelsObservational cohortMultivariate analysisAP initiationPsychiatric Hospitalization After Enrollment in Coordinated Specialty Care: Unexpected Gender- and Age-Related Disparities
Vohs J, Tayfur S, Li F, Song Z, Breitborde N, Cahill J, Chaudhry S, Ferrara M, Heckers S, Satchivi A, Silverstein S, Taylor S, Tso I, Weiss A, Breier A, Srihari V. Psychiatric Hospitalization After Enrollment in Coordinated Specialty Care: Unexpected Gender- and Age-Related Disparities. Schizophrenia Bulletin 2025, 52: sbaf260. PMID: 41863376, PMCID: PMC13005094, DOI: 10.1093/schbul/sbaf260.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsLength of stayLonger length of stayFirst-episode psychosisEarly Psychosis Intervention NetworkCoordinated Specialty CareEarly psychosis careAge-related disparitiesBlack/African American participantsNegative binomial regressionPsychosis careIntervention NetworkSpecialty careMultidisciplinary interventionWhite participantsHospitalization ratesPsychiatric hospitalBinomial regressionHospital outcomesElevated riskFunctional declineFrequent admissionsPrimary outcomeHospitalization frequencyHealthcare burdenFrequent hospitalizationsEnhancing Coordinated Specialty Care Through Early Detection: Impact of Reduced Duration of Untreated Psychosis
Hazan H, Ferrara M, Zhou B, Li F, Imetovski S, Sykes L, Pollard J, Cahill J, Gibbs-Dean T, Corbera S, Karmani S, Riley S, Tayfur S, Tek C, Keshavan M, Srihari V. Enhancing Coordinated Specialty Care Through Early Detection: Impact of Reduced Duration of Untreated Psychosis. Schizophrenia Bulletin 2025, 51: 1730-1737. PMID: 40339151, PMCID: PMC12597490, DOI: 10.1093/schbul/sbaf044.Peer-Reviewed Original ResearchCitationsConceptsDuration of untreated psychosisFirst-episode psychosisCoordinated Specialty CareUntreated psychosisMediation analysisShorter duration of untreated psychosisFirst-episode psychosis patientsEarly interventionEarly psychosisBenefits of early interventionPsychosisGAFFunctional outcomesGlobal assessmentEarly detection campaignsSpecialty careIntake processRecovery outcomesSpecial treatmentQuality of lifeStreamlining referralsFunctional recoveryScoresPatientsInterventionHONE: A learning health system platform for advancing early intervention in first episode psychosis
Mathis W, Gibbs-Dean T, Cahill J, Srihari V. HONE: A learning health system platform for advancing early intervention in first episode psychosis. Schizophrenia Research 2025, 280: 1-9. PMID: 40209525, PMCID: PMC12052476, DOI: 10.1016/j.schres.2025.04.009.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsLearning health systemEarly intervention servicesFirst-episode psychosisLearning health system frameworkQuality improvementDiverse healthcare settingsContinuous quality improvementMental health outcomesUser-centered designPatient-reported outcomesEvidence-based outcomesDiverse data sourcesCare deliveryEpisode psychosisImprove careKnowledge translationHealth outcomesHealth systemHealthcare settingsLifetime illnessHealthcare reformData visualizationUser engagementTransformation frameworkDuration of untreated psychosisThe problem of missing data for learning health systems focused on first-episode psychosis
Robinson D, Schooler N, John M, Cahill J, Gonzalez C, Marcy P, Adams C, Distasio M, Gerber C, Hackett B, Nunez M, Srihari V, Kane J. The problem of missing data for learning health systems focused on first-episode psychosis. Schizophrenia Research 2025, 279: 79-86. PMID: 40174487, PMCID: PMC12051462, DOI: 10.1016/j.schres.2025.03.021.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsFirst-episode psychosisCoordinated Specialty CarePrematurely terminated treatmentLearning health systemGlobal functioningCharacteristics of individualsLong-actingPatient-reported outcomesSocial scaleExploratory analysisPsychosisProcess of recoveryHealth systemCSC treatmentParticipantsUnstable housingRates of missing dataClinic patientsSpecialty careImprove careUS clinicsScaleLong durationCommercial insuranceResearch prioritiesForging a learning health system for early psychosis: Insights from the academic community EPINET
Vohs J, Cahill J, Taylor S, Heckers S, Weiss A, Chaudhry S, Silverstein S, Tso I, Breitborde N, Vinson A, Lapidos A, Visco A, Satchivi A, Gaunnac M, Breier A, Srihari V. Forging a learning health system for early psychosis: Insights from the academic community EPINET. Schizophrenia Research 2025, 278: 109-118. PMID: 40147210, PMCID: PMC12011207, DOI: 10.1016/j.schres.2025.03.020.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLearning healthcare systemEarly Psychosis Intervention NetworkQuality improvementClinical workflowLearning health systemProvision of intervention servicesQuality improvement effortsCulture of continuous learningIntervention NetworkHealth systemDisease trajectoryInterventional careHealthcare systemPractice-based researchImprovement effortsEvidence-basedClinical sitesIntervention servicesSocietal costsSteering CommitteeFirst-episode psychosisImplementation lessonsEarly psychosisEngaging stakeholdersSix-month intervalsThe STEP Learning Collaborative: A statewide Learning Healthcare System (LHS) for first episode psychosis
Yoviene Sykes L, Levine N, Tayfur S, Gibbs-Dean T, Hazan H, Imetovski S, James J, Karmani S, Mathis W, Markovich P, Purushothaman D, Riley S, Tek C, Veillette C, Cahill J, Giard J, Marracino A, Barrette K, Bozak S, Gregory F, McDermott G, Srihari V. The STEP Learning Collaborative: A statewide Learning Healthcare System (LHS) for first episode psychosis. Schizophrenia Research 2025, 278: 96-108. PMID: 40132282, PMCID: PMC11981821, DOI: 10.1016/j.schres.2025.03.029.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsLearning healthcare systemLearning CollaborativeHealthcare systemSchizophrenia spectrum disordersPopulation health outcomesLearning health systemSystems of careCare modelHigh-quality treatmentStage of illnessHealth outcomesHealth systemWorkforce developmentDuration of untreated psychosisStatewide systemEarly stages of illnessEarly psychosisWorkforce readinessStrengthening integrationPolicy advocacyLeverage informaticsCareEpisode psychosisStakeholder engagementUntreated psychosis
2024
The Academic Community Early Psychosis Intervention Network: Toward building a novel learning health system across six US states
Vohs J, Srihari V, Vinson A, Lapidos A, Cahill J, Taylor S, Heckers S, Weiss A, Chaudhry S, Silverstein S, Tso I, Breitborde N, Breier A. The Academic Community Early Psychosis Intervention Network: Toward building a novel learning health system across six US states. Learning Health Systems 2024, 9: e10471. PMID: 40247900, PMCID: PMC12000763, DOI: 10.1002/lrh2.10471.Peer-Reviewed Original ResearchCitationsAltmetricConceptsEarly Psychosis Intervention NetworkIntervention NetworkFirst-episode psychosisRegional clinical networksLearning health systemQuality improvement projectQuality improvement effortsCulture of continuous learningData elementsPrimary diagnosis of schizophreniaConsecutive 6-month intervalsFirst-episode psychosis clinicUsual careSuperior patient outcomesSpecialty servicesHealth systemClinical teamImplementation meetingsQuality assurance effortsImprovement projectClinical networksHealthcare systemPractice-based researchImprovement effortsQuality improvementTimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis
Mathis W, Ferrara M, Cahill J, Karmani S, Tayfur S, Srihari V. TimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis. PLOS ONE 2024, 19: e0302116. PMID: 39028697, PMCID: PMC11259254, DOI: 10.1371/journal.pone.0302116.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPathways to CareDuration of untreated psychosisManual transcription errorsDevelopment of targeted interventionsReduce duration of untreated psychosisHealthcare accessibility researchReal-time data entryImprove patient outcomesEpisode psychosisCare pathwaysPatient journeyHealthcare contextPatient outcomesPaper-basedConversion of collected dataFEP treatmentData collection processNew HavenData collection methodsData entryTranscription errorsUntreated psychosisOpen-source codebaseData collectionWeb-based toolAccelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis
Wannan C, Nelson B, Addington J, Allott K, Anticevic A, Arango C, Baker J, Bearden C, Billah T, Bouix S, Broome M, Buccilli K, Cadenhead K, Calkins M, Cannon T, Cecci G, Chen E, Cho K, Choi J, Clark S, Coleman M, Conus P, Corcoran C, Cornblatt B, Diaz-Caneja C, Dwyer D, Ebdrup B, Ellman L, Fusar-Poli P, Galindo L, Gaspar P, Gerber C, Glenthøj L, Glynn R, Harms M, Horton L, Kahn R, Kambeitz J, Kambeitz-Ilankovic L, Kane J, Kapur T, Keshavan M, Kim S, Koutsouleris N, Kubicki M, Kwon J, Langbein K, Lewandowski K, Light G, Mamah D, Marcy P, Mathalon D, McGorry P, Mittal V, Nordentoft M, Nunez A, Pasternak O, Pearlson G, Perez J, Perkins D, Powers A, Roalf D, Sabb F, Schiffman J, Shah J, Smesny S, Spark J, Stone W, Strauss G, Tamayo Z, Torous J, Upthegrove R, Vangel M, Verma S, Wang J, Rossum I, Wolf D, Wolff P, Wood S, Yung A, Agurto C, Alvarez-Jimenez M, Amminger P, Armando M, Asgari-Targhi A, Cahill J, Carrión R, Castro E, Cetin-Karayumak S, Chakravarty M, Cho Y, Cotter D, D’Alfonso S, Ennis M, Fadnavis S, Fonteneau C, Gao C, Gupta T, Gur R, Gur R, Hamilton H, Hoftman G, Jacobs G, Jarcho J, Ji J, Kohler C, Lalousis P, Lavoie S, Lepage M, Liebenthal E, Mervis J, Murty V, Nicholas S, Ning L, Penzel N, Poldrack R, Polosecki P, Pratt D, Rabin R, Eichi H, Rathi Y, Reichenberg A, Reinen J, Rogers J, Ruiz-Yu B, Scott I, Seitz-Holland J, Srihari V, Srivastava A, Thompson A, Turetsky B, Walsh B, Whitford T, Wigman J, Yao B, Yuen H, Ahmed U, Byun A, Chung Y, Do K, Hendricks L, Huynh K, Jeffries C, Lane E, Langholm C, Lin E, Mantua V, Santorelli G, Ruparel K, Zoupou E, Adasme T, Addamo L, Adery L, Ali M, Auther A, Aversa S, Baek S, Bates K, Bathery A, Bayer J, Beedham R, Bilgrami Z, Birch S, Bonoldi I, Borders O, Borgatti R, Brown L, Bruna A, Carrington H, Castillo-Passi R, Chen J, Cheng N, Ching A, Clifford C, Colton B, Contreras P, Corral S, Damiani S, Done M, Estradé A, Etuka B, Formica M, Furlan R, Geljic M, Germano C, Getachew R, Goncalves M, Haidar A, Hartmann J, Jo A, John O, Kerins S, Kerr M, Kesselring I, Kim H, Kim N, Kinney K, Krcmar M, Kotler E, Lafanechere M, Lee C, Llerena J, Markiewicz C, Matnejl P, Maturana A, Mavambu A, Mayol-Troncoso R, McDonnell A, McGowan A, McLaughlin D, McIlhenny R, McQueen B, Mebrahtu Y, Mensi M, Hui C, Suen Y, Wong S, Morrell N, Omar M, Partridge A, Phassouliotis C, Pichiecchio A, Politi P, Porter C, Provenzani U, Prunier N, Raj J, Ray S, Rayner V, Reyes M, Reynolds K, Rush S, Salinas C, Shetty J, Snowball C, Tod S, Turra-Fariña G, Valle D, Veale S, Whitson S, Wickham A, Youn S, Zamorano F, Zavaglia E, Zinberg J, Woods S, Shenton M. Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis. Schizophrenia Bulletin 2024, 50: 496-512. PMID: 38451304, PMCID: PMC11059785, DOI: 10.1093/schbul/sbae011.Peer-Reviewed Original ResearchCitationsAltmetricConceptsClinical high-risk individualsClinical high riskNational Institute of Mental HealthInstitute of Mental HealthAttenuated positive symptomsPersistent negative symptomsTransition to psychosisCHR statusHigh riskNegative symptomsPositive symptomsAnxiety symptomsPsychosocial functioningCognitive dataOutcomes of individualsDigital health technologiesDaily surveysPsychosisSCZPublic health needsMental healthNovel pharmacological interventionsSchizophreniaClinical outcomesHealth needs
Clinical Trials
Current Trials
Sleep Dependent Learning in Schizophrenia and Psychosis Risk Syndrome
IRB ID1201009524RoleSub InvestigatorPrimary Completion Date01/31/2022Recruiting ParticipantsGenderBothAge18 years - 55 years
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- February 09, 2026
Kaufman, Wilkins, Cahill Present at ARCH Event
- January 16, 2026
Krystal First Guest at ARCH Leadership Pathway Meet and Greet Series
- July 18, 2025
Doximity Poll: Yale Psychiatry Residency Program Ranks #3 Nationally
- August 13, 2024
Cahill Selected to be Director of Yale Psychiatry Residency Program
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