2020
Salmonella expresses foreign genes during infection by degrading their silencer
Choi J, Groisman EA. Salmonella expresses foreign genes during infection by degrading their silencer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 8074-8082. PMID: 32209674, PMCID: PMC7149492, DOI: 10.1073/pnas.1912808117.Peer-Reviewed Original ResearchConceptsForeign genesH-NSForeign DNAHeat-stable nucleoid-structuring (H-NS) proteinH-NS bindingNucleoid structuring proteinGram-negative bacterial speciesFacultative intracellular pathogenPhoP proteinLon proteaseProtease LonRegulatory sequencesVirulence regulatorGene silencingIntramacrophage survivalStructuring proteinBacterial speciesGenesInside macrophagesIntracellular pathogensSerovar TyphimuriumUncovered mechanismProteinVirulence genesDNA
2018
Elongation factor P controls translation of the mgtA gene encoding a Mg2+ transporter during Salmonella infection
Choi E, Nam D, Choi J, Park S, Lee J, Lee E. Elongation factor P controls translation of the mgtA gene encoding a Mg2+ transporter during Salmonella infection. MicrobiologyOpen 2018, 8: e00680. PMID: 29949242, PMCID: PMC6460261, DOI: 10.1002/mbo3.680.Peer-Reviewed Original ResearchConceptsMgtA geneProline codonsControl translationIntramacrophage survivalPathogen Salmonella enterica serovar TyphimuriumElongation factor PConsecutive proline codonsOpen reading frameSalmonella enterica serovar TyphimuriumEnterica serovar TyphimuriumTranslational controlReading frameSalmonella pathogenesisMRNA sequencesGenesCodonSerovar TyphimuriumRibosomesFactor P
2017
Activation of master virulence regulator PhoP in acidic pH requires the Salmonella-specific protein UgtL
Choi J, Groisman EA. Activation of master virulence regulator PhoP in acidic pH requires the Salmonella-specific protein UgtL. Science Signaling 2017, 10 PMID: 28851823, PMCID: PMC5966036, DOI: 10.1126/scisignal.aan6284.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimicrobial Cationic PeptidesBacterial ProteinsDisease Models, AnimalFemaleGene Expression Regulation, BacterialHydrogen-Ion ConcentrationMagnesiumMembrane ProteinsMiceMice, Inbred BALB CPeptidesPhosphorylationSalmonella InfectionsSalmonella typhimuriumSignal TransductionVirulenceConceptsPhoP activation