Hyesun Cho, PhD
Postdoctoral Associate in NeuroscienceAbout
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Postdoctoral Associate in Neuroscience
Departments & Organizations
- All Institutions
Education & Training
- PhD
- Seoul National University (2020)
Research
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Overview
Medical Research Interests
Brain; Neurons
Public Health Interests
Bioinformatics
ORCID
0000-0003-1254-768X
Research at a Glance
Yale Co-Authors
Frequent collaborators of Hyesun Cho's published research.
Publications Timeline
A big-picture view of Hyesun Cho's research output by year.
Research Interests
Research topics Hyesun Cho is interested in exploring.
Navjot Kaur, PhD, MS
Nenad Sestan, MD, PhD
Hao Huang, MD, MPH
Ipsita Chatterjee
Kartik Pattabiraman, MD, PhD
Kevin Gobeske, MPH, PhD, MD
9Publications
823Citations
Publications
2026
Adaptive evolution of gene regulatory networks in mammalian neocortex
Li Z, Kaur N, Santpere G, Muchnik S, Sindhu S, Qi C, Shibata M, Clément O, Klarić T, de Martin X, Luria V, Cho H, Li M, Shibata A, Choi S, Kim H, Tebbenkamp A, Ma S, Han W, Kim S, Pochareddy S, Duy P, Xing X, Bao Y, Xu X, Gladwyn-Ng I, Cullen H, Paolino A, Fenlon L, Kozulin P, Suárez R, Risgaard R, Gulden F, Karger A, Suzuki I, Hirata T, Gobeske K, Richards L, Sousa A, Heng J, Sestan N. Adaptive evolution of gene regulatory networks in mammalian neocortex. Nature 2026, 1-11. PMID: 41851468, DOI: 10.1038/s41586-026-10226-y.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCis-regulatory elementsAdaptive evolutionEvolution of gene regulatory networksPutative cis-regulatory elementsGene expressionGene regulatory networksLandscape of gene expressionAssociated with genesTarget gene expressionModern reptilesHighest conservationRegulatory networksBinding motifRegulatory nodesPrefrontal cortexEvolutionary adaptationIntellectual disabilityMolecular diversityBrain connectivityExcitatory projection neuronsZBTB18Complex brainsProjection neuronsMammalsBrainQuantitatively controlled and measured-traumatic brain injury impairs adult neurogenesis and alters neuropathological signatures in mice
Yang S, Kim S, Park U, Im H, Cho H, Lee K, Yoo J, Hyeon S, Lee J, Rhyu I, Lee J, McKee A, Yoon E, Ryu H. Quantitatively controlled and measured-traumatic brain injury impairs adult neurogenesis and alters neuropathological signatures in mice. Theranostics 2026, 16: 193-219. PMID: 41328339, PMCID: PMC12665107, DOI: 10.7150/thno.114693.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsTraumatic brain injuryChronic traumatic encephalopathyBrain injuryConclusions:Methods:Pathological featuresAxonal damageAdult hippocampal neurogenesisBehavior of miceClosed-head injury modelGenes associated with synaptic functionNeuropathological signatureTraumatic encephalopathyHuman traumatic brain injuryHippocampal neurogenesisAdult neurogenesisGlobal health concernNeuropathological characteristicsTherapeutic strategiesNeurofilament levelsEffective treatmentBehavioral changesInjury modelSynaptic functionMice
2025
Specification of claustro-amygdalar and palaeocortical neurons and circuits
Kaur N, Kovner R, Gulden F, Pletikos M, Andrijevic D, Zhu T, Silbereis J, Shibata M, Shibata A, Liu Y, Ma S, Salla N, de Martin X, Klarić T, Burke M, Franjic D, Cho H, Yuen M, Chatterjee I, Soric P, Esakkimuthu D, Moser M, Santpere G, Mineur Y, Pattabiraman K, Picciotto M, Huang H, Sestan N. Specification of claustro-amygdalar and palaeocortical neurons and circuits. Nature 2025, 638: 469-478. PMID: 39814878, PMCID: PMC11821539, DOI: 10.1038/s41586-024-08361-5.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBasolateral amygdala complexPrefrontal cortex connectivityPrefrontal cortexNeuropsychiatric disordersExcitatory neuronsSymptoms of neuropsychiatric disordersEarly-life disruptionAmygdala complexPiriform cortexTemporal cortexDevelopmental shiftReciprocal connectionsCortexClaustrumBehavior modificationSensory informationTranscription factor SOX4DisordersTfap2dNeuronsSimilar alterationsCross-species analysisPiriformSOX11Transcription factors
2021
Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models
Woo J, Cho H, Seol Y, Kim SH, Park C, Yousefian-Jazi A, Hyeon SJ, Lee J, Ryu H. Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models. Antioxidants 2021, 10: 229. PMID: 33546471, PMCID: PMC7913624, DOI: 10.3390/antiox10020229.Peer-Reviewed Original ResearchCitationsAltmetricConceptsOxidative stressMitochondrial functionMitochondrial dysfunctionAntioxidant therapeutic strategiesAmyotrophic lateral sclerosisNeuronal damageLateral sclerosisParkinson's diseaseTherapeutic strategiesNeuronal activitySubcellular eventsAlzheimer's diseaseBiochemical energyNeurodegenerative disordersLiving organismDiseaseHuntington's diseaseNeurodegenerationArt computational modelsMitochondriaDysfunctionBrainSclerosisStressOrganisms
2020
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production
Chun H, Im H, Kang YJ, Kim Y, Shin JH, Won W, Lim J, Ju Y, Park YM, Kim S, Lee SE, Lee J, Woo J, Hwang Y, Cho H, Jo S, Park JH, Kim D, Kim DY, Seo JS, Gwag BJ, Kim YS, Park KD, Kaang BK, Cho H, Ryu H, Lee CJ. Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production. Nature Neuroscience 2020, 23: 1555-1566. PMID: 33199896, DOI: 10.1038/s41593-020-00735-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsReactive astrocytesAlzheimer's diseaseAPP/PS1 micePathogenesis of ADReactivity of astrocytesBrains of patientsAppropriate experimental modelsGlial activationPS1 miceAstrocytic reactivityBrain atrophyPathological featuresNeuronal deathMonoamine oxidase BPathological hallmarkAD modelPrecise molecular mechanismsAnimal modelsAstrocytesCognitive impairmentPathological contributionExperimental modelDiseaseOxidase BEventual deathAlterations of transcriptome signatures in head trauma-related neurodegenerative disorders
Cho H, Hyeon SJ, Shin JY, Alvarez VE, Stein TD, Lee J, Kowall NW, McKee AC, Ryu H, Seo JS. Alterations of transcriptome signatures in head trauma-related neurodegenerative disorders. Scientific Reports 2020, 10: 8811. PMID: 32483284, PMCID: PMC7264177, DOI: 10.1038/s41598-020-65916-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseBlotting, WesternCell Adhesion MoleculesChronic Traumatic EncephalopathyCraniocerebral TraumaEndothelial CellsFemaleGene OntologyGene Regulatory NetworksHumansMaleMemoryMiddle AgedNerve Tissue ProteinsNeurogliaNeuronsReal-Time Polymerase Chain ReactionSequence Analysis, RNASynaptic TransmissionTemporal LobeTranscription, GeneticTranscriptomeConceptsProtein kinase AProtein kinase CQuantitative real-time PCRChronic traumatic encephalopathyCell adhesion moleculeSynaptotagmin-1Transcriptome signaturesGene co-expression network analysisCAM-related genesCo-expression network analysisAMPA receptor genesCalmodulin-dependent protein kinase IICalcium/calmodulin-dependent protein kinase IIUnique transcriptome signaturesTraumatic brain injuryProtein kinase IIAlzheimer's diseaseFunction-related genesKinase AMemory function-related genesKinase IISpecific pathological markersKinase CWestern blot analysisReal-time PCREpigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease
Lee MY, Lee J, Hyeon SJ, Cho H, Hwang YJ, Shin J, McKee AC, Kowall NW, Kim J, Stein TD, Hwang D, Ryu H. Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease. Aging Cell 2020, 19: e13153. PMID: 32419307, PMCID: PMC7294781, DOI: 10.1111/acel.13153.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGenome-wide ChIPMRNA sequence dataBiological network analysisHistone H3K9me3Heterochromatin remodelingEpigenetic modificationsAD postmortem brainsEpigenetic signaturesFunction-related genesH3K9me3Cell motilityHeterochromatin condensationEpigenetic alterationsEpigenomeEpigenome signaturesNeuronal differentiationAlzheimer's diseaseExpression levelsHeterochromatinIntegrated analysisPostmortem brainsMRNA expression levelsSporadic Alzheimer's diseaseNetwork analysisPotential role
2017
Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy
Seo JS, Lee S, Shin JY, Hwang YJ, Cho H, Yoo SK, Kim Y, Lim S, Kim YK, Hwang EM, Kim SH, Kim CH, Hyeon SJ, Yun JY, Kim J, Kim Y, Alvarez VE, Stein TD, Lee J, Kim DJ, Kim JI, Kowall NW, Ryu H, McKee AC. Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy. Experimental & Molecular Medicine 2017, 49: e333-e333. PMID: 28524178, PMCID: PMC5454448, DOI: 10.1038/emm.2017.56.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProtein phosphataseChronic traumatic encephalopathyProtein phosphatase expressionRNA sequencing analysisCalcium-signaling pathwayIntraneuronal tau aggregatesTranscriptome analysisNeuropathological featuresMAP kinaseAlzheimer's diseasePhosphatase expressionSequencing analysisDistinctive neuropathological featuresRepetitive head injuryPhosphatase activityPost-mortem brain tissueAltered expressionProgressive neurodegenerative disorderNovel therapeutic approachesCommon pathological mechanismCell linesTau aggregatesNeurodegenerative diseasesNeurodegenerative disordersTraumatic encephalopathy
2016
Comprehensive Analysis of the Transcriptional and Mutational Landscape of Follicular and Papillary Thyroid Cancers
Yoo SK, Lee S, Kim SJ, Jee HG, Kim BA, Cho H, Song YS, Cho SW, Won JK, Shin JY, Park do J, Kim JI, Lee KE, Park YJ, Seo JS. Comprehensive Analysis of the Transcriptional and Mutational Landscape of Follicular and Papillary Thyroid Cancers. PLOS Genetics 2016, 12: e1006239. PMID: 27494611, PMCID: PMC4975456, DOI: 10.1371/journal.pgen.1006239.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsClassical papillary thyroid carcinomaFollicular thyroid carcinomaFollicular adenomaHistological featuresThyroid cancerMolecular subtypesThyroid carcinomaInvasive follicular thyroid carcinomaSimilar histological featuresPapillary thyroid cancerPapillary thyroid carcinomaFollicular thyroid neoplasmBenign follicular adenomaPAX8-PPARGIndolent behaviorPreoperative diagnosisNovel molecular subtypesFollicular variantTherapeutic approachesNRAS mutationsThyroid neoplasmsMIFTCUpregulation of genesBRAF-likeCarcinoma
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