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INFORMATION FOR

    Gretchen Hermes, MD, PhD

    Associate Professor of Psychiatry

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    Additional Titles

    Medical Director, APT Foundation

    Chief Psychiatrist, Yale Stress Center

    Addiction Psychiatry Fellowship Coordinator, APT Foundation

    About

    Titles

    Associate Professor of Psychiatry

    Medical Director, APT Foundation; Chief Psychiatrist, Yale Stress Center; Addiction Psychiatry Fellowship Coordinator, APT Foundation

    Biography

    Gretchen Hermes, MD, PhD, MTS is a psychiatrist, psychoanalyst, researcher, and educator whose work explores the intersections of neuroscience, psychoanalysis, and theology in the understanding of trauma, addiction, and human vulnerability. Her scholarship and clinical work focus on how experiences of social disconnection, stress, and illness shape brain function, identity, and recovery across the lifespan.

    Dr. Hermes earned her MD and PhD in neuroscience and human development from the University of Chicago, where she trained under the mentorship of Martha K. McClintock. She completed residency training in psychiatry at Yale School of Medicine, pursued psychoanalytic training at the Western New England Institute for Psychoanalysis, and holds a Master of Theological Studies from Harvard Divinity School.

    Her early research used preclinical models to investigate how social isolation and disruptions in attachment influence stress physiology and disease vulnerability. This work established a scientific foundation for her subsequent clinical and scholarly focus on addiction, trauma, and the neurobiological consequences of relational loss. Dr. Hermes has published widely across neuroscience, psychiatry, and addiction studies and is currently editing a special issue of the Journal of the American Psychoanalytic Association devoted to addiction.

    Dr. Hermes has held leadership roles in addiction treatment and psychiatric education, including serving as Medical Director at the APT Foundation and contributing to research and clinical work with the Yale Interdisciplinary Stress Center. She has taught and supervised medical students, residents, and fellows at Yale School of Medicine and has developed prison-based educational initiatives that use memoir writing to explore trauma, identity, and mental health.

    She currently serves as Medical Director of Psychiatry at Gaylord Hospital, where she provides psychiatric consultation for patients with complex neurological, psychiatric, and medical conditions and collaborates with interdisciplinary rehabilitation teams. Her work at Gaylord is focused on developing a psychosocial recovery research program examining the interactions between trauma history, substance use, cognitive vulnerability, and rehabilitation outcomes.

    Dr. Hermes is the founder of Reward Reimagined (rewardreimagined.org), a public initiative exploring addiction, reward, and human meaning. She is currently completing book-length projects that bring neuroscience, psychoanalysis, and theology into dialogue around a central question: how can psychiatry respond to suffering in ways that restore connection, meaning, and the possibility of belonging?

    Last Updated on March 24, 2026.

    Appointments

    • Psychiatry

      Associate Professor on Term
      Primary

    Other Departments & Organizations

    Education & Training

    Research Fellowship, Schizophrenia
    Yale University (2013)
    Residency
    Yale University (2011)
    MD
    University of Chicago Pritzker School of Medicine (2007)
    Postdoctoral Fellowship, NIH, Interdisciplinary Program in Immunology
    University of Chicago (2005)
    PhD
    University of Chicago (2003)
    MA
    Harvard Divinity School (1997)

    Research

    Overview

    Dr. Hermes work at Gaylord is focused on developing a psychosocial recovery research program that examines the interactions among trauma history, substance use, cognitive vulnerability, and rehabilitation outcomes.

    Dr. Hermes’s research trajectory spans preclinical models of stress and chronic disease, human studies of stress and addiction, and clinical trials in drug development for chronic mental illness. Across these domains, her work has centered on understanding how biological vulnerability and lived experience converge in the development and persistence of psychiatric illness.

    Medical Research Interests

    Psilocybin; Psychological Distress; Spirituality

    Public Health Interests

    Aging; Chronic Diseases; HIV/AIDS; Mental Health; Substance Use, Addiction

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Gretchen Hermes's published research.

    Publications

    2025

    2024

    Academic Achievements & Community Involvement

    Activities

    • activity

      Ad Hoc Reviewer

    • activity

      California Breast Cancer Research Program; University of California, Office of the President

    • activity

      Female Opioid Research and Clinical Experts (FORCE)

    Honors

    • honor

      NARSAD Young Investigator Grant

    • honor

      Workshop on Schizophrenia and Related Disorders, Travel Award and Stipend

    • honor

      Daniel X. and Mary Freedman Fellowship in Academic Psychiatry

    • honor

      APA-Pfizer M.D., Ph.D. Research Fellowship Award

    • honor

      Power Day Award, Psychiatry, for a resident nominated by 3rd year medical class, who serves as a true role model for Yale medical students

    Clinical Care

    Overview

    Gretchen Hermes, MD, PhD, specializes in addiction psychiatry, providing care for individuals with addiction-related illnesses and co-occurring psychiatric diagnoses, including depression, anxiety, and psychotic spectrum illnesses.

    Dr. Hermes emphasizes facilitating change and optimizing learning as chief psychiatrist at the Yale Stress Center. "If a therapy doesn't work, we will work together to find one that does," she says.

    In her capacity as an associate professor of psychiatry at Yale School of Medicine, Dr. Hermes explores the effects of medications on drug craving and withdrawal, as well as the long-term impacts of early life trauma compared to acute stress. Dr. Hermes is also involved in studies on the role of certain proteins in mental illness, which could represent a shift in understanding the energy and biogenesis involved in these conditions.

    Dr. Hermes received her medical degree from the University of Chicago Pritzker School of Medicine and completed her residency at Yale School of Medicine. She also completed post-doctoral work in infectious disease and psychoanalytic training at the Western New England Institute for Psychoanalysis.

    Clinical Specialties

    Psychiatry; Addiction Medicine

    Board Certifications

    • Psychiatry

      Certification Organization
      AB of Psychiatry & Neurology
      Original Certification Date
      2025

    Get In Touch

    Contacts

    Clinic Fax Number
    Appointment Number
    Mailing Address

    Psychiatry

    2 Church St S

    New Haven, CT 06519

    United States

    Locations

    • Horvath Lab

      Lab

      Brady Memorial Laboratory

      310 Cedar Street, Ste 416

      New Haven, CT 06510

    • Yale Stress Center

      Academic Office

      Doctors Building

      2 Church Street South, Fl 2nd, Ste 208, Rm 209

      New Haven, CT 06519

    • Patient Care Locations

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