Gary Cline, PhD
Professor Emeritus of Medicine (Endocrinology)DownloadHi-Res Photo
Cards
Appointments
Endocrinology
Primary
Additional Titles
Director, Analytical Core, Mouse Metabolic Phenotyping Center at Yale Univ. School of Medicine
Co-Director, Clinical Metabolism Core, Yale Diabetes Research Center
Contact Info
Appointments
Endocrinology
Primary
Additional Titles
Director, Analytical Core, Mouse Metabolic Phenotyping Center at Yale Univ. School of Medicine
Co-Director, Clinical Metabolism Core, Yale Diabetes Research Center
Contact Info
Appointments
Endocrinology
Primary
Additional Titles
Director, Analytical Core, Mouse Metabolic Phenotyping Center at Yale Univ. School of Medicine
Co-Director, Clinical Metabolism Core, Yale Diabetes Research Center
Contact Info
About
Titles
Professor Emeritus of Medicine (Endocrinology)
Director, Analytical Core, Mouse Metabolic Phenotyping Center at Yale Univ. School of Medicine; Co-Director, Clinical Metabolism Core, Yale Diabetes Research Center
Appointments
Endocrinology
EmeritusPrimary
Other Departments & Organizations
- Endocrinology
- Fellowship Training
- Internal Medicine
- Mouse Metabolic Phenotyping Center
- Yale Ventures
Education & Training
- PhD
- University of Missouri (1988)
Research
Overview
Medical Research Interests
Diabetes Mellitus; Endocrinology; Lipid Metabolism; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular
Research at a Glance
Yale Co-Authors
Frequent collaborators of Gary Cline's published research.
Gerald I Shulman, MD, PhD, MACP, MACE, FRCP
Mario Kahn
Daniel F Vatner, MD, PhD
Dongyan Zhang
Jiasheng Zhang, MD
Lawrence Young, MD
Publications
2024
SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts
Goedeke L, Ma Y, Gaspar R, Nasiri A, Lee J, Zhang D, Galsgaard K, Hu X, Zhang J, Guerrera N, Li X, LaMoia T, Hubbard B, Haedersdal S, Wu X, Stack J, Dufour S, Butrico G, Kahn M, Perry R, Cline G, Young L, Shulman G. SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts. Journal Of Clinical Investigation 2024, 134: e176708. PMID: 39680452, PMCID: PMC11645152, DOI: 10.1172/jci176708.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsSodium-glucose cotransporter type 2Heart failureKetone oxidationGas chromatography-mass spectrometryFatty acid oxidationLeft ventricular ejection fractionReduced myocardial oxidative stressVentricular ejection fractionKetone supplementationWeeks of treatmentMyocardial oxidative stressDecreased pyruvate oxidationInduce heart failurePlasma glucose levelsIn vivo effectsSGLT2i treatmentEjection fractionAssociated with improvementsAwake ratsSGLT2 inhibitionCardioprotective benefitsLiquid chromatography-tandem mass spectrometryPlasma ketonesRates of ketonizationChromatography-tandem mass spectrometryHigh-fat-diet-induced hepatic insulin resistance per se attenuates murine de novo lipogenesis
Goedeke L, Strober J, Suh R, Paolella L, Li X, Rogers J, Petersen M, Nasiri A, Casals G, Kahn M, Cline G, Samuel V, Shulman G, Vatner D. High-fat-diet-induced hepatic insulin resistance per se attenuates murine de novo lipogenesis. IScience 2024, 27: 111175. PMID: 39524330, PMCID: PMC11550620, DOI: 10.1016/j.isci.2024.111175.Peer-Reviewed Original ResearchAltmetricConceptsDuration of high-fat dietAttenuated insulin signalingHigh-fat dietHepatic insulin resistanceInsulin signalingInsulin stimulationLipogenic substrateStimulation of de novo lipogenesisReduced lipogenesisHFD feedingReduce DNLInsulin resistanceResistance per seLipogenesisInsulin resistance per sePathway selectionGlucose metabolismHepatic IRMiceFat dietSREBP1cINSR
Clinical Trials
Current Trials
Imaging pancreatic beta-cells with PET neuroimaging agent 11C-PHNO
HIC ID2000021287RoleSub InvestigatorPrimary Completion Date07/31/2021Recruiting ParticipantsGenderBothAge18 years - 65 yearsThe Role of Hepatic De Novo Lipogenesis (DNL) in the Pathogenesis of Hepatic Steatosis
HIC ID1604017607RoleSub InvestigatorPrimary Completion Date05/01/2023Recruiting ParticipantsGenderBothAge12 years - 30 years
Academic Achievements & Community Involvement
honor Team Science Award
National AwardAssociation for Clinical and Translational ScienceDetails06/14/2016United States
News
News
- August 06, 2021
Metabolism Expert Cline Retires From YSM
- December 16, 2020
Discoveries & Impact (December 2020)
- September 17, 2020
Discoveries & Impact (September 2020)
- August 01, 2018Source: The Journal of Nuclear Medicine
PET Imaging of Beta Cell Mass Featured in Journal of Nuclear Medicine
Get In Touch
Contacts
Email
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