Felicia A. Hardi
Wu Tsai Postdoc. Assoc. in Psych & PsychiatryAbout
Research
Publications
2026
Cortisol stress reactivity and cumulative output associations with structural neural network architecture in adolescents
Guzman J, Hardi F, Peckins M, Mitchell C, Tillem S, Monk C, Lopez-Duran N, Hyde L. Cortisol stress reactivity and cumulative output associations with structural neural network architecture in adolescents. Psychoneuroendocrinology 2026, 191: 107938. PMID: 42308566, DOI: 10.1016/j.psyneuen.2026.107938.Peer-Reviewed Original ResearchCortisol response to acute stressResponse to acute stressCortisol stress reactivityStress reactivityCortisol levelsAcute stressHypothalamic-pituitary-adrenal (HPA) axisFunctional brain network organizationNetwork organizationPeak cortisol levelsBrain network organizationElevated cortisol levelsLong-term potentiationGray matter structuresLow socioeconomic status familiesLaboratory stressorIndividual differencesSmall-world propensityCortisol responseNetwork segregationAssociated with deleterious effectsMatter structuresNeural connectionsEfficient information transferStressorsChildhood environment clusters reveal heterogeneous associations between large-scale brain networks and youth mental health symptoms
Hardi F, Keding T, Holt-Gosselin B, Goldfarb E, Gee D. Childhood environment clusters reveal heterogeneous associations between large-scale brain networks and youth mental health symptoms. Psychological Medicine 2026, 56: e134. PMID: 42100879, PMCID: PMC13161815, DOI: 10.1017/s0033291726104115.Peer-Reviewed Original ResearchConceptsMental health symptomsYouth mental healthMental healthFunctional connectivityHealth symptomsNeural patternsBrain network functional connectivityBrain-behavior associationsHigher symptom levelsNetwork functional connectivityFamilial risk groupFunctional network connectivityClusters of youthYouth mental health symptomsMental Health AssociationFrontoparietal networkNeural correlatesSymptom levelsPsychopathological functioningGroup differencesPsychological symptomsFamilial riskChildhood environmentLongitudinal sampleBrain developmentChildhood Material Hardship Linked to Adolescent Neurocognition: A Computational Modeling Approach
Zhang Y, Weigard A, Hardi F, Hong S, Huntley E, Mitchell C, Hyde L, Monk C. Childhood Material Hardship Linked to Adolescent Neurocognition: A Computational Modeling Approach. Developmental Science 2026, 29: e70213. PMID: 42087395, PMCID: PMC13144713, DOI: 10.1111/desc.70213.Peer-Reviewed Original ResearchConceptsEfficiency of evidence accumulationGoal-directed behaviorCognitive functionCognitive processesAttention difficultiesAttention problemsBehavioral measuresBehavioral measures of cognitive functionHigher-order cognitive functionsMeasures of cognitive functionComputational models of cognitionEvidence accumulation processModels of cognitionGrowth curve modelsDrift rateMental health outcomesMaterial hardshipAdolescent neurocognitionAdolescents' attentionDecision-relevant informationEvidence accumulationInconsistent findingsCurve modelIndirect pathwaysTask-based performanceCharacterizing Resting-State Frontoparietal-Amygdala Network Connectivity as a Potential Moderator of the Developmental Link Between Executive Functioning and Internalizing Symptoms: A Group Iterative Multiple Model Estimation-Based Approach
Hardi F, Gunther K, Keding T, Petrie D, Pérez-Edgar K, Geier C, Gee D. Characterizing Resting-State Frontoparietal-Amygdala Network Connectivity as a Potential Moderator of the Developmental Link Between Executive Functioning and Internalizing Symptoms: A Group Iterative Multiple Model Estimation-Based Approach. Biological Psychiatry Global Open Science 2026, 6: 100724. PMID: 42109921, PMCID: PMC13157069, DOI: 10.1016/j.bpsgos.2026.100724.Peer-Reviewed Original ResearchExecutive functionInternalizing symptomsInhibitory controlFrontoparietal networkAttention shiftsInternalizing behaviorsGroup iterative multiple model estimationResting state functional connectivitySubgroup differencesData-driven subgroupsAttentional processesBehavioral rigidityMultiple model estimationFunctional connectivityDevelopmental linkAssociated with longitudinal changesSubgroup membershipS-GIMMEExploratory analysisRegistered ReportLongitudinal changesSymptomsAttention mechanismDLPFCAmygdalaAssociations between surrogates of prenatal lead DNA methylation and adolescent neural network architecture
Tung R, O’Neill C, Smith T, Hardi F, Goetschius L, Huntley E, Meier H, Hyde L, Notterman D, Monk C, Mitchell C. Associations between surrogates of prenatal lead DNA methylation and adolescent neural network architecture. Brain And Environment 2026, 5: 100013. DOI: 10.1016/j.braen.2026.100013.Peer-Reviewed Original ResearchPrenatal Pb exposureSmall-world propensityStructural brain networksAged 9Diffusion MRI scansFuture of familiesPb exposureBrain networksGlobal network efficiencyBrain structuresCognitive functionMarginalized youthPB scoresAssociated with differencesAdolescentsPrenatal lead exposureConnectional organizationGlobal efficiencyDNA methylation surrogatesNetwork efficiencyMRI scansNeural developmentLongitudinal cohortDNA methylation
2025
Trauma-predictive brain network connectivity adaptively responds to mild acute stress
Hardi F, Ye J, Zhou I, Bai Z, Nguyen D, Loetscher K, Pratt J, Harris B, Gee D, Goldfarb E. Trauma-predictive brain network connectivity adaptively responds to mild acute stress. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2505965122. PMID: 40737323, PMCID: PMC12327799, DOI: 10.1073/pnas.2505965122.Peer-Reviewed Original ResearchConceptsBrain networksTrauma exposureAcute stressCommunity sampleConnectome-based predictive modelingCommunity sample of adultsAssociated with lower depressive symptomsMedial frontal cortexSalience network connectivityDefault mode networkMild acute stressLower depressive symptomsConnectivity of brain networksBrain network connectivityStress-exposed groupsSample of adultsSubsample of participantsFunctional connectivity networksRelative to controlsSalience networkFrontal cortexMode networkDepressive symptomsTraumatic experiencesMotor regions
2024
Developmental Timing of Associations Among Parenting, Brain Architecture, and Mental Health
Michael C, Gard A, Tillem S, Hardi F, Dunn E, Smith A, McLoyd V, Brooks-Gunn J, Mitchell C, Monk C, Hyde L. Developmental Timing of Associations Among Parenting, Brain Architecture, and Mental Health. JAMA Pediatrics 2024, 178: 1326-1336. PMID: 39466276, PMCID: PMC11581745, DOI: 10.1001/jamapediatrics.2024.4376.Peer-Reviewed Original ResearchConceptsParental psychological aggressionWarm parentingMiddle childhoodMental healthLate childhoodBrain architectureAssociated with mental healthPsychological aggressionLongitudinal birth cohort studyHarsh parentingLong-term health outcomesNeural associationsAssociated with reduced anxietyEarly adulthoodFunctional magnetic resonance imagingYouth-reported anxietyDevelopmental timing of exposureAssociated with brain developmentHealth outcomesMental illnessPopulation-basedMain OutcomesEarly childhoodCumulative associationDepressive symptomsMother–child closeness and adolescent structural neural networks: a prospective longitudinal study of low-income families
Hong S, Hardi F, Tillem S, Goetschius L, Brooks-Gunn J, McLoyd V, Lopez-Duran N, Mitchell C, Hyde L, Monk C. Mother–child closeness and adolescent structural neural networks: a prospective longitudinal study of low-income families. Social Cognitive And Affective Neuroscience 2024, 19: nsae083. PMID: 39512200, PMCID: PMC11631430, DOI: 10.1093/scan/nsae083.Peer-Reviewed Original ResearchConceptsMother-child closenessLow-income familiesStudy of low-income familiesWhite matter organizationAged 9Increased global efficiencyPositive youth developmentChild reportsBrain organizationProspective longitudinal studyMatter organizationLongitudinal sampleAffectionate bondYouth developmentNeural pathwaysGlobal efficiencyConnectional organizationStructural networkChildrenChildhood adversity and adolescent mental health: Examining cumulative and specificity effects across contexts and developmental stages
Hardi F, Peckins M, Mitchell C, McLoyd V, Brooks-Gunn J, Hyde L, Monk C. Childhood adversity and adolescent mental health: Examining cumulative and specificity effects across contexts and developmental stages. Development And Psychopathology 2024, 37: 1954-1970. PMID: 39359017, PMCID: PMC11965435, DOI: 10.1017/s0954579424001512.Peer-Reviewed Original ResearchYouth psychopathologyChildhood adversityPredictive of internalizing symptomsPredictors of internalizing symptomsImpact of childhood adversityFuture of familiesTiming of adversityAdolescent mental healthPsychological aggressionExternalizing symptomsMiddle childhoodParenting stressPsychopathologyLongitudinal sampleStructured life course modeling approachMental healthAdversityAged 9Early childhoodSpecific effectsAged 3ChildhoodSymptomsYouthToddlerhoodLatent Profiles of Childhood Adversity, Adolescent Mental Health, and Neural Network Connectivity
Hardi F, Beltz A, McLoyd V, Brooks-Gunn J, Huntley E, Mitchell C, Hyde L, Monk C. Latent Profiles of Childhood Adversity, Adolescent Mental Health, and Neural Network Connectivity. JAMA Network Open 2024, 7: e2430711. PMID: 39196556, PMCID: PMC11358864, DOI: 10.1001/jamanetworkopen.2024.30711.Peer-Reviewed Original ResearchConceptsMental healthAdolescent mental healthHigh adversityPopulation-based birth cohortChildhood adversityMultiple adversitiesAged 0 to 9 yearsMaternal mental healthAdverse childhood experiencesMultiple risk factorsAdverse profilePsychiatric morbidityMain OutcomesAdverse levelsBirth cohortSalience networkFrontoparietal networkHigher symptomsYouth-report measureCohort studyBrain healthLatent profilesLow adversityBrain connectivityChildhood experiences