2022
Optimization of FLASH proton beams using a track‐repeating algorithm
Wang Q, Titt U, Mohan R, Guan F, Zhao Y, Yang M, Yepes P. Optimization of FLASH proton beams using a track‐repeating algorithm. Medical Physics 2022, 49: 6684-6698. PMID: 35900902, DOI: 10.1002/mp.15849.Peer-Reviewed Original Research
2020
Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns
Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Scientific Reports 2020, 10: 3199. PMID: 32081928, PMCID: PMC7035246, DOI: 10.1038/s41598-020-60246-5.Peer-Reviewed Original ResearchConceptsIntensity-modulated proton therapyLow-energy beamsIntensity modulation patternCurrent treatment planProton therapyBiological effectsDelivery strategiesTarget doseTherapeutic indexTreatment planHigh-energy beamsEffective doseEnhanced biological effectClinical potentialTherapyCancer cellsDoseBragg peak
2018
A mechanistic relative biological effectiveness model-based biological dose optimization for charged particle radiobiology studies
Guan F, Geng C, Carlson DJ, H D, Bronk L, Gates D, Wang X, Kry SF, Grosshans D, Mohan R. A mechanistic relative biological effectiveness model-based biological dose optimization for charged particle radiobiology studies. Physics In Medicine And Biology 2018, 64: 015008. PMID: 30523805, DOI: 10.1088/1361-6560/aaf5df.Peer-Reviewed Original Research
2015
A Novel Algorithm for Solving the True Coincident Counting Issues in Monte Carlo Simulations for Radiation Spectroscopy
Guan F, Johns JM, Vasudevan L, Zhang G, Tang X, Poston JW, Braby LA. A Novel Algorithm for Solving the True Coincident Counting Issues in Monte Carlo Simulations for Radiation Spectroscopy. Health Physics 2015, 108: 574-579. PMID: 25905518, DOI: 10.1097/hp.0000000000000185.Peer-Reviewed Original ResearchConceptsHigh-purity germanium detectorDetection efficiencyRadiation spectroscopyGermanium detectorCoincident countsGeant4 Monte Carlo simulation toolkitSimulated pulse height spectraMonte Carlo simulation toolkitPulse height spectraRadiation fieldRadiation sourceCoincident radiationNuclear fissionHeight spectraMonte Carlo methodSource particlesSimulation toolkitSpectroscopy problemsMonte Carlo simulationsDetectorCarlo methodCarlo simulationsSpectroscopySpectraNuclear fuel