2020
Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns
Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Scientific Reports 2020, 10: 3199. PMID: 32081928, PMCID: PMC7035246, DOI: 10.1038/s41598-020-60246-5.Peer-Reviewed Original ResearchConceptsIntensity-modulated proton therapyLow-energy beamsIntensity modulation patternCurrent treatment planProton therapyBiological effectsDelivery strategiesTarget doseTherapeutic indexTreatment planHigh-energy beamsEffective doseEnhanced biological effectClinical potentialTherapyCancer cellsDoseBragg peak
2018
Patterns of Local-Regional Failure After Intensity Modulated Radiation Therapy or Passive Scattering Proton Therapy With Concurrent Chemotherapy for Non-Small Cell Lung Cancer
Yang P, Xu T, Gomez DR, Deng W, Wei X, Elhalawani H, Jin H, Guan F, Mirkovic D, Xu Y, Mohan R, Liao Z. Patterns of Local-Regional Failure After Intensity Modulated Radiation Therapy or Passive Scattering Proton Therapy With Concurrent Chemotherapy for Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2018, 103: 123-131. PMID: 30165127, DOI: 10.1016/j.ijrobp.2018.08.031.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerInternal target volumePlanning target volumeCell lung cancerLarge tumorsRegional failureMarginal failureLocal failureLung cancerSmall tumorsCox proportional hazards analysisTarget volumeLocal-regional failureOnly independent predictorOverall survival rateProportional hazards analysisProton therapyComputed tomography simulationPassive Scattering Proton TherapyConcurrent chemotherapyLocoregional failureFavorable survivalIndependent predictorsTumor controlTomography scan