2020
Dosimetric and Radiobiological Comparison of Five Techniques for Postmastectomy Radiotherapy with Simultaneous Integrated Boost
Tang D, Liang Z, Guan F, Yang Z. Dosimetric and Radiobiological Comparison of Five Techniques for Postmastectomy Radiotherapy with Simultaneous Integrated Boost. BioMed Research International 2020, 2020: 9097352. PMID: 32775448, PMCID: PMC7391102, DOI: 10.1155/2020/9097352.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBreast NeoplasmsFemaleHumansMastectomyMiddle AgedRadiotherapy DosageRadiotherapy Planning, Computer-AssistedConceptsNormal tissue complication probabilitySimultaneous integrated boostHighest normal-tissue complication probabilityPostmastectomy radiotherapyIntegrated boostLeft-sided breast cancer treatmentComplication probabilityHybrid intensity-modulated radiotherapyLeft-sided breast cancerSimilar dosimetric resultsSuperior dose sparingBetter dose coverageBetter conformity indexBreast cancer treatmentIntensity-modulated radiotherapyOAR mean doseContralateral breastMean doseTD plansBreast cancerConformity indexRadiobiological comparisonDose sparingDose coverageClinical practiceExploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns
Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Scientific Reports 2020, 10: 3199. PMID: 32081928, PMCID: PMC7035246, DOI: 10.1038/s41598-020-60246-5.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsCell Line, TumorHumansLinear Energy TransferMaleMonte Carlo MethodPhotonsProstatic NeoplasmsProton TherapyRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, Intensity-ModulatedTranslational Research, BiomedicalConceptsIntensity-modulated proton therapyLow-energy beamsIntensity modulation patternCurrent treatment planProton therapyBiological effectsDelivery strategiesTarget doseTherapeutic indexTreatment planHigh-energy beamsEffective doseEnhanced biological effectClinical potentialTherapyCancer cellsDoseBragg peak
2018
A mechanistic relative biological effectiveness model-based biological dose optimization for charged particle radiobiology studies
Guan F, Geng C, Carlson DJ, H D, Bronk L, Gates D, Wang X, Kry SF, Grosshans D, Mohan R. A mechanistic relative biological effectiveness model-based biological dose optimization for charged particle radiobiology studies. Physics In Medicine And Biology 2018, 64: 015008. PMID: 30523805, DOI: 10.1088/1361-6560/aaf5df.Peer-Reviewed Original ResearchAlgorithmsHeavy Ion RadiotherapyHumansMonte Carlo MethodPhantoms, ImagingRadiotherapy Planning, Computer-AssistedRelative Biological EffectivenessPatterns of Local-Regional Failure After Intensity Modulated Radiation Therapy or Passive Scattering Proton Therapy With Concurrent Chemotherapy for Non-Small Cell Lung Cancer
Yang P, Xu T, Gomez DR, Deng W, Wei X, Elhalawani H, Jin H, Guan F, Mirkovic D, Xu Y, Mohan R, Liao Z. Patterns of Local-Regional Failure After Intensity Modulated Radiation Therapy or Passive Scattering Proton Therapy With Concurrent Chemotherapy for Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2018, 103: 123-131. PMID: 30165127, DOI: 10.1016/j.ijrobp.2018.08.031.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCarcinoma, Non-Small-Cell LungChemoradiotherapyFemaleHumansLung NeoplasmsMaleMiddle AgedProportional Hazards ModelsProton TherapyRadiotherapy Planning, Computer-AssistedRadiotherapy, Intensity-ModulatedTreatment FailureTumor BurdenConceptsNon-small cell lung cancerInternal target volumePlanning target volumeCell lung cancerLarge tumorsRegional failureMarginal failureLocal failureLung cancerSmall tumorsCox proportional hazards analysisTarget volumeLocal-regional failureOnly independent predictorOverall survival rateProportional hazards analysisProton therapyComputed tomography simulationPassive Scattering Proton TherapyConcurrent chemotherapyLocoregional failureFavorable survivalIndependent predictorsTumor controlTomography scanInvestigation of the dose perturbation effect for therapeutic beams with the presence of a 1.5 T transverse magnetic field in magnetic resonance imaging-guided radiotherapy.
Shao W, Tang X, Bai Y, Shu D, Geng C, Gong C, Guan F. Investigation of the dose perturbation effect for therapeutic beams with the presence of a 1.5 T transverse magnetic field in magnetic resonance imaging-guided radiotherapy. Journal Of Cancer Research And Therapeutics 2018, 14: 184-195. PMID: 29516984, DOI: 10.4103/jcrt.jcrt_1349_16.Peer-Reviewed Original ResearchMeSH KeywordsCarbonHumansMagnetic FieldsMagnetic Resonance ImagingMonte Carlo MethodNeoplasmsPhotonsRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, Image-GuidedConceptsT transverse magnetic fieldBeam energyCarbon ion beamsTherapeutic beamTransverse magnetic fieldMagnetic fieldDose perturbationsDose perturbation effectsIon beamMagnetic resonance imaging-guided radiotherapyHigher beam energiesUniform magnetic fieldWater-air interfaceAir-tissue interfacePhoton beamsRadiation fieldPerturbation effectsBragg peakProper energyBeamBeam typeDose distributionEnergyProtonsRadiotherapy methods
2015
Analysis of the track‐ and dose‐averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code
Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans D, Mohan R, Titt U. Analysis of the track‐ and dose‐averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code. Medical Physics 2015, 42: 6234-6247. PMID: 26520716, PMCID: PMC4600086, DOI: 10.1118/1.4932217.Peer-Reviewed Original Research