2022
Optimization of FLASH proton beams using a track‐repeating algorithm
Wang Q, Titt U, Mohan R, Guan F, Zhao Y, Yang M, Yepes P. Optimization of FLASH proton beams using a track‐repeating algorithm. Medical Physics 2022, 49: 6684-6698. PMID: 35900902, DOI: 10.1002/mp.15849.Peer-Reviewed Original ResearchAdaptation and dosimetric commissioning of a synchrotron-based proton beamline for FLASH experiments
Yang M, Wang X, Guan F, Titt U, Iga K, Jiang D, Takaoka T, Tootake S, Katayose T, Umezawa M, Schüler E, Frank S, Lin SH, Sahoo N, Koong AC, Mohan R, Zhu XR. Adaptation and dosimetric commissioning of a synchrotron-based proton beamline for FLASH experiments. Physics In Medicine And Biology 2022, 67: 165002. PMID: 35853442, PMCID: PMC9422888, DOI: 10.1088/1361-6560/ac8269.Peer-Reviewed Original ResearchConceptsAdvanced Markus chamberProton beamlineEBT-XD filmsMarkus chamberIrradiation conditionsUltra-high dose ratesUnique time structureFLASH irradiationAverage dose rateAbsolute dose calibrationDose rateBeamlineDose calibrationFlash experimentsTime structureAbsolute doseIrradiation platformMonte Carlo simulationsFLASH effectField sizeFlash conditionsDose controlGy sPrecise dosimetryCarlo simulations
2020
Dosimetric and Radiobiological Comparison of Five Techniques for Postmastectomy Radiotherapy with Simultaneous Integrated Boost
Tang D, Liang Z, Guan F, Yang Z. Dosimetric and Radiobiological Comparison of Five Techniques for Postmastectomy Radiotherapy with Simultaneous Integrated Boost. BioMed Research International 2020, 2020: 9097352. PMID: 32775448, PMCID: PMC7391102, DOI: 10.1155/2020/9097352.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBreast NeoplasmsFemaleHumansMastectomyMiddle AgedRadiotherapy DosageRadiotherapy Planning, Computer-AssistedConceptsNormal tissue complication probabilitySimultaneous integrated boostHighest normal-tissue complication probabilityPostmastectomy radiotherapyIntegrated boostLeft-sided breast cancer treatmentComplication probabilityHybrid intensity-modulated radiotherapyLeft-sided breast cancerSimilar dosimetric resultsSuperior dose sparingBetter dose coverageBetter conformity indexBreast cancer treatmentIntensity-modulated radiotherapyOAR mean doseContralateral breastMean doseTD plansBreast cancerConformity indexRadiobiological comparisonDose sparingDose coverageClinical practiceExploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns
Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Scientific Reports 2020, 10: 3199. PMID: 32081928, PMCID: PMC7035246, DOI: 10.1038/s41598-020-60246-5.Peer-Reviewed Original ResearchConceptsIntensity-modulated proton therapyLow-energy beamsIntensity modulation patternCurrent treatment planProton therapyBiological effectsDelivery strategiesTarget doseTherapeutic indexTreatment planHigh-energy beamsEffective doseEnhanced biological effectClinical potentialTherapyCancer cellsDoseBragg peak
2019
Using the Proton Energy Spectrum and Microdosimetry to Model Proton Relative Biological Effectiveness
Newpower M, Patel D, Bronk L, Guan F, Chaudhary P, McMahon SJ, Prise KM, Schettino G, Grosshans DR, Mohan R. Using the Proton Energy Spectrum and Microdosimetry to Model Proton Relative Biological Effectiveness. International Journal Of Radiation Oncology • Biology • Physics 2019, 104: 316-324. PMID: 30731186, PMCID: PMC6499683, DOI: 10.1016/j.ijrobp.2019.01.094.Peer-Reviewed Original ResearchMeSH KeywordsLinear Energy TransferMonte Carlo MethodProton TherapyProtonsRadiotherapy DosageRelative Biological EffectivenessConceptsProton energy spectraMicrodosimetric kinetic modelDose-mean lineal energyRelative biological effectivenessProton irradiation experimentsEnergy spectrumLineal energyLineal energy yIrradiation experimentsLineal energy distributionsDose-averaged linear energy transferBiological effectivenessDifferent proton energiesLinear energy transferRBE modelsProton energyBragg curveEnergy distributionGeant4-DNAProton irradiationRBE data
2018
Investigation of the dose perturbation effect for therapeutic beams with the presence of a 1.5 T transverse magnetic field in magnetic resonance imaging-guided radiotherapy.
Shao W, Tang X, Bai Y, Shu D, Geng C, Gong C, Guan F. Investigation of the dose perturbation effect for therapeutic beams with the presence of a 1.5 T transverse magnetic field in magnetic resonance imaging-guided radiotherapy. Journal Of Cancer Research And Therapeutics 2018, 14: 184-195. PMID: 29516984, DOI: 10.4103/jcrt.jcrt_1349_16.Peer-Reviewed Original ResearchConceptsT transverse magnetic fieldBeam energyCarbon ion beamsTherapeutic beamTransverse magnetic fieldMagnetic fieldDose perturbationsDose perturbation effectsIon beamMagnetic resonance imaging-guided radiotherapyHigher beam energiesUniform magnetic fieldWater-air interfaceAir-tissue interfacePhoton beamsRadiation fieldPerturbation effectsBragg peakProper energyBeamBeam typeDose distributionEnergyProtonsRadiotherapy methods
2015
Analysis of the track‐ and dose‐averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code
Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans D, Mohan R, Titt U. Analysis of the track‐ and dose‐averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code. Medical Physics 2015, 42: 6234-6247. PMID: 26520716, PMCID: PMC4600086, DOI: 10.1118/1.4932217.Peer-Reviewed Original Research