2022
Enhanced Radiation-Sparing Effects of Ultra-High Dose Rate Proton Radiation (FLASH-RT) in a Human Induced Pluripotent Stem Cell-Derived Cerebral Organoid Model
Bronk J, Bronk L, Singh S, Guan F, Wang X, Zhu X, Schueler E, Jiang D, Mohan R, Koong A, Lang F, Grosshans D. Enhanced Radiation-Sparing Effects of Ultra-High Dose Rate Proton Radiation (FLASH-RT) in a Human Induced Pluripotent Stem Cell-Derived Cerebral Organoid Model. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: s66. DOI: 10.1016/j.ijrobp.2022.07.456.Peer-Reviewed Original ResearchGlioma stem-like cellsNeural progenitor cellsCerebral organoid modelFLASH-RTMature neuronsRadiation-related side effectsProgenitor cellsSpecific cell populationsOrganoid modelsPotential protective effectPreclinical animal modelsCell populationsAggressive brain tumorConventional dose ratesLactate dehydrogenase releaseDelivery of radiationTumor cell proliferationHuman brain tissueStem-like cellsChronic neuroinflammationTumor responseAntitumoral effectivenessProtective effectBrain tumorsSide effects
2015
Chemoradiation therapy using cyclopamine-loaded liquid–lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles
You J, Zhao J, Wen X, Wu C, Huang Q, Guan F, Wu R, Liang D, Li C. Chemoradiation therapy using cyclopamine-loaded liquid–lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles. Journal Of Controlled Release 2015, 202: 40-48. PMID: 25637565, PMCID: PMC4394992, DOI: 10.1016/j.jconrel.2015.01.031.Peer-Reviewed Original ResearchConceptsCombination therapyHigher antitumor cytotoxicityMurine breast cancerMouse xenograft modelCell linesDesirable pharmacokinetic propertiesChemoradiation therapyTumor sizeTumor responseMouse survivalPancreatic cancerAntitumor cytotoxicitySystemic administrationBreast cancerIntravenous injectionPreclinical studiesTumor relapseRadiation therapyXenograft modelIntratumoral injectionAdenocarcinoma modelTumor growthLower clonogenicityCell responsesTherapy