Enhanced Radiation-Sparing Effects of Ultra-High Dose Rate Proton Radiation (FLASH-RT) in a Human Induced Pluripotent Stem Cell-Derived Cerebral Organoid Model
Bronk J, Bronk L, Singh S, Guan F, Wang X, Zhu X, Schueler E, Jiang D, Mohan R, Koong A, Lang F, Grosshans D. Enhanced Radiation-Sparing Effects of Ultra-High Dose Rate Proton Radiation (FLASH-RT) in a Human Induced Pluripotent Stem Cell-Derived Cerebral Organoid Model. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: s66. DOI: 10.1016/j.ijrobp.2022.07.456.Peer-Reviewed Original ResearchGlioma stem-like cellsNeural progenitor cellsCerebral organoid modelFLASH-RTMature neuronsRadiation-related side effectsProgenitor cellsSpecific cell populationsOrganoid modelsPotential protective effectPreclinical animal modelsCell populationsAggressive brain tumorConventional dose ratesLactate dehydrogenase releaseDelivery of radiationTumor cell proliferationHuman brain tissueStem-like cellsChronic neuroinflammationTumor responseAntitumoral effectivenessProtective effectBrain tumorsSide effects