2021
Uncertainty in tissue equivalent proportional counter assessments of microdosimetry and RBE estimates in carbon radiotherapy
Hartzell S, Guan F, Taylor P, Peterson C, Taddei P, Kry S. Uncertainty in tissue equivalent proportional counter assessments of microdosimetry and RBE estimates in carbon radiotherapy. Physics In Medicine And Biology 2021, 66: 155018. PMID: 34252894, DOI: 10.1088/1361-6560/ac1366.Peer-Reviewed Original ResearchConceptsTissue equivalent proportional counterCommon mathematical modelPerturbed valuesMicrodosimetric kinetic modelLow-energy cutMonte Carlo toolkitMathematical modelCounting statisticsCentral beam axisEnergy deposition distributionsStatistic uncertaintyInput parametersTherapeutic carbon beamsLineal energy valuesCarbon beamBeam axisTEPC measurementsSources of uncertaintyWall effectsModel input parametersMicrodosimetric spectraInherent uncertaintyRelative biological effectivenessUncertaintyCarbon radiotherapy
2019
Using the Proton Energy Spectrum and Microdosimetry to Model Proton Relative Biological Effectiveness
Newpower M, Patel D, Bronk L, Guan F, Chaudhary P, McMahon SJ, Prise KM, Schettino G, Grosshans DR, Mohan R. Using the Proton Energy Spectrum and Microdosimetry to Model Proton Relative Biological Effectiveness. International Journal Of Radiation Oncology • Biology • Physics 2019, 104: 316-324. PMID: 30731186, PMCID: PMC6499683, DOI: 10.1016/j.ijrobp.2019.01.094.Peer-Reviewed Original ResearchConceptsProton energy spectraMicrodosimetric kinetic modelDose-mean lineal energyRelative biological effectivenessProton irradiation experimentsEnergy spectrumLineal energyLineal energy yIrradiation experimentsLineal energy distributionsDose-averaged linear energy transferBiological effectivenessDifferent proton energiesLinear energy transferRBE modelsProton energyBragg curveEnergy distributionGeant4-DNAProton irradiationRBE data