2020
Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques
Bronk L, Guan F, Patel D, Ma D, Kroger B, Wang X, Tran K, Yiu J, Stephan C, Debus J, Abdollahi A, Jäkel O, Mohan R, Titt U, Grosshans DR. Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques. Cancers 2020, 12: 3658. PMID: 33291477, PMCID: PMC7762185, DOI: 10.3390/cancers12123658.Peer-Reviewed Original ResearchHeidelberg Ion Beam Therapy CenterRelative biological effectivenessCarbon ionsDose-mean lineal energyDose-averaged linear energy transferBiological effectivenessLinear energy transferMonte Carlo systemHelium ionsParticle beamsLineal energyBeam pathBragg peakMaximum relative biological effectivenessEnergy transferProtonsHeliumIonsTherapy CenterBeamExperimental platformSpatial distributionEnergyExperimental resultsSub
2018
Physical parameter optimization scheme for radiobiological studies of charged particle therapy
Geng C, Gates D, Bronk L, Ma D, Guan F. Physical parameter optimization scheme for radiobiological studies of charged particle therapy. Physica Medica 2018, 51: 13-21. PMID: 30278981, PMCID: PMC6173200, DOI: 10.1016/j.ejmp.2018.06.001.Peer-Reviewed Original ResearchConceptsIon beamParticle therapyPhysical quantitiesDose-averaged linear energy transferC-ion beamsLinear energy transferBiological dose optimizationParticle beamsProton beamBragg curveBragg peakWhole target regionBeamCorresponding physical dataEnergy transferProtonsMonte Carlo simulationsAppropriate biophysical modelSpatial distributionSOBPRadiobiological studiesCarlo simulationsDose spreadIonsLET
2014
TH‐A‐19A‐05: Modeling Physics Properties and Biologic Effects Induced by Proton and Helium Ions
Taleei R, Titt U, Peeler C, Guan F, Mirkovic D, Grosshans D, Mohan R. TH‐A‐19A‐05: Modeling Physics Properties and Biologic Effects Induced by Proton and Helium Ions. Medical Physics 2014, 41: 534-534. DOI: 10.1118/1.4889538.Peer-Reviewed Original ResearchMonte Carlo codeFragmentation cross sectionsHelium ionsBragg peakCarlo codeCross sectionsGeneral purpose Monte Carlo codeLight ionsMicrodosimetric parametersProton beamEnergy spectrumCarbon ionsBragg curveDepth dosePhysics propertiesWater phantomPhysical propertiesRBE increasesProtonsMonte Carlo simulationsDose distributionFLUKABeamIonsCurve calculations
2013
SU‐E‐T‐502: In Search of the Optimum Ion for Radiotherapy
Guan F, Titt U, Bangert M, Mohan R. SU‐E‐T‐502: In Search of the Optimum Ion for Radiotherapy. Medical Physics 2013, 40: 320-320. DOI: 10.1118/1.4814931.Peer-Reviewed Original ResearchFragmentation tailC ionsBragg peakGeant4 Monte Carlo toolkitMonte Carlo toolkitC-ion beamsLateral penumbraPeak dose ratioNarrow Bragg peaksMonoenergetic beamsTypes of ionsIon beamEnergy dependenceBroad beamLET distributionsPristine beamWater phantomNuclear fragmentsBeamDose contributionSpatial doseDifferent ionsProtonsSmaller penumbraIons