About
Titles
Assistant Professor
Biography
Evangelos K. Oikonomou, MD, DPhil is a cardiologist and physician-scientist, and an Assistant Professor of Medicine in the Section of Cardiovascular Medicine at Yale School of Medicine. His work focuses on the development and clinical translation of artificial intelligence–enabled digital biomarkers, with an emphasis on computer vision applications for precision phenotyping in cardiovascular disease. His research aims to create scalable, cost-effective tools that integrate seamlessly into routine clinical workflows to improve diagnosis, risk stratification, and therapeutic decision-making.
Dr. Oikonomou graduated as valedictorian from the National and Kapodistrian University of Athens School of Medicine and earned his doctorate (DPhil) in Medical Sciences from the University of Oxford. He subsequently completed the Yale Physician-Scientist Training Program, including residency in Internal Medicine and fellowship training in Cardiovascular Medicine. His research has been supported by a Ruth L. Kirschstein National Research Service Award (F32, 2023-2025) from the National Heart, Lung, and Blood Institute, a Robert A. Winn Excellence in Clinical Trials Program (2025–2028) as well as the American Heart Association (2026-2029) through Career Development Awards (CDA).
He has received multiple national and international honors, including Young Investigator Awards from the American Heart Association (2021, 2023), American College of Cardiology (2024), European Society of Cardiology (2018, 2019), and the Society of Cardiovascular Computed Tomography (2017), as well as the American Society for Clinical Investigation Emerging Generation (E-Gen) Award (2024) and the Wiesman Award from the ATTR Early-Career Research Forum (2025).
Dr. Oikonomou’s interdisciplinary research lies at the intersection of cardiovascular and cardiometabolic medicine and focuses on four major areas: (i) the development and clinical translation of adipose tissue imaging biomarkers to elucidate the early links between adiposity and cardiovascular disease; (ii) the design and validation of deep learning algorithms for point-of-care echocardiography to detect both common and under-recognized cardiomyopathies; (iii) the data-driven evaluation of treatment-effect heterogeneity in clinical trials to inform adaptive and precision-enriched trial design; and (iv) the multimodal integration of these approaches into clinical care pathways through innovative clinical informatics approaches.
His work has been published in The Lancet, The Lancet Digital Health, JAMA, JAMA Cardiology, European Heart Journal, JACC, Circulation, and Diabetes Care, among others.
Looking ahead, Dr. Oikonomou’s research is focused on leveraging multimodal AI to redefine diagnostic and prognostic frameworks across the cardiovascular disease spectrum, from subclinical detection to dynamic risk prediction, with a strong emphasis on real-world implementation and equitable access to advanced diagnostics.
A complete list of publications is available at: https://scholar.google.com/citations?user=GgJv1SMAAAAJ&hl=en
Departments & Organizations
- ABIM Physician-Scientist Research Pathway
- Internal Medicine
- Yale Medicine
- Yale New Haven Health System
Education & Training
- Clinical fellow
- Yale School of Medicine (2025)
- Post-doctoral fellow
- Yale School of Medicine (2025)
- Resident
- Yale School of Medicine (2021)
- Intern
- Yale School of Medicine (2020)
- DPhil
- University of Oxford (2020)
- MD
- University of Athens School of Health Sciences (2015)
Board Certifications
Cardiovascular Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2025
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2022
Research
Overview
Medical Research Interests
Academic Achievements & Community Involvement
News & Links
News
- February 11, 2026
Using AI to Guide AI
- June 23, 2025
AI Tool Interprets Echocardiograms in Minutes, New Yale Study Finds
- January 31, 2025
AI Can Identify Cardiomyopathies Early, Says New Study
- January 23, 2025
New AI Tool Identifies Risk of Future Heart Failure
Get In Touch
Contacts
Yale School of Medicine
100 Church St S
New Haven, CT 06519
United States
Locations
Patient Care Locations
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