Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsScott Swenson, MD, PhD
Assistant Clinical ProfessorAbout
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Biography
I am investigating the role of stem and progenitor cells in the liver and pancreas during normal development and in response to injury.
Last Updated on April 07, 2025.
Appointments
Internal Medicine
Assistant Clinical ProfessorPrimary
Other Departments & Organizations
Education & Training
- Fellow
- Yale School of Medicine (2006)
- Resident
- Yale-New Haven Hospital (2001)
- MD
- University of Cincinnati (1999)
- PhD
- University of Cincinnati (1997)
- BA
- Oberlin College (1985)
Research
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Overview
Medical Research Interests
Hepatitis; Liver Cirrhosis; Pancreatic Diseases
ORCID
0000-0001-7963-5305
Research at a Glance
Yale Co-Authors
Frequent collaborators of Scott Swenson's published research.
Publications Timeline
A big-picture view of Scott Swenson's research output by year.
Diane Krause, MD, PhD
Michael Schilsky, MD
Timothy Nottoli, PhD
15Publications
571Citations
Publications
2025
Erratum: Effects of trientine and penicillamine on intestinal copper uptake: A mechanistic 64Cu PET/CT study in healthy humans
Kirk F, Munk D, Swenson E, Quicquaro A, Vendelbo M, Schilsky M, Ott P, Sandahl T. Erratum: Effects of trientine and penicillamine on intestinal copper uptake: A mechanistic 64Cu PET/CT study in healthy humans. Hepatology 2025, 82: e37-e37. PMID: 40421917, DOI: 10.1097/hep.0000000000001367.Peer-Reviewed Original ResearchCitations
2023
Effects of trientine and penicillamine on intestinal copper uptake: A mechanistic 64Cu PET/CT study in healthy humans
Kirk F, Munk D, Swenson E, Quicquaro A, Vendelbo M, Schilsky M, Ott P, Sandahl T. Effects of trientine and penicillamine on intestinal copper uptake: A mechanistic 64Cu PET/CT study in healthy humans. Hepatology 2023, 79: 1065-1074. PMID: 38088886, PMCID: PMC11019997, DOI: 10.1097/hep.0000000000000708.Peer-Reviewed Original ResearchCitationsAltmetricConceptsUrinary copper excretionStandard uptake valueIntestinal copper absorptionUptake valueCopper excretionIntestinal absorptionPositron emission tomography/CT scanMean standard uptake valueSame therapeutic targetsPET/CT studiesVenous blood samplesCopper absorptionIntestinal copper uptakeEffects of drugsUrinary excretionCT scanHealthy volunteersBlood samplesHealthy humansTrientineTherapeutic targetBody weightCT studiesWilson's diseaseD-penicillamineEffects of tetrathiomolybdate on copper metabolism in healthy volunteers and in patients with Wilson disease
Kirk F, Munk D, Swenson E, Quicquaro A, Vendelbo M, Larsen A, Schilsky M, Ott P, Sandahl T. Effects of tetrathiomolybdate on copper metabolism in healthy volunteers and in patients with Wilson disease. Journal Of Hepatology 2023, 80: 586-595. PMID: 38081365, DOI: 10.1016/j.jhep.2023.11.023.Peer-Reviewed Original ResearchCitationsAltmetricConceptsEffect of tetrathiomolybdateWilson's diseaseBiliary copper excretionBiliary excretionHealthy volunteersCopper excretionWD patientsBis-choline tetrathiomolybdateNeurologic Wilson diseaseClinical trial numberPresent human studyTrial numberPET/CTCopper metabolismIntestinal copper uptakeMechanism of actionPET/MRINeurological worseningConventional therapyVenous bloodClinical trialsLower riskAnimal studiesHuman studiesCopper chelator
2016
Daclatasvir, Sofosbuvir, and Ribavirin Combination for HCV Patients with Advanced Cirrhosis or Post-transplant Recurrence: Final Results of the ALLY-1 Study: 2016 ACG Presidential Poster Award
Poordad F, Schiff E, Vierling J, Landis C, Fontana R, Yang R, McPhee F, Noviello S, Swenson E. Daclatasvir, Sofosbuvir, and Ribavirin Combination for HCV Patients with Advanced Cirrhosis or Post-transplant Recurrence: Final Results of the ALLY-1 Study: 2016 ACG Presidential Poster Award. The American Journal Of Gastroenterology 2016, 111: s346. DOI: 10.14309/00000434-201610001-00774.Peer-Reviewed Original ResearchCitationsAltmetric
2011
Direct conversion of mouse fibroblasts to hepatocyte‐like cells using forced expression of endodermal transcription factors
Swenson ES. Direct conversion of mouse fibroblasts to hepatocyte‐like cells using forced expression of endodermal transcription factors. Hepatology 2011, 55: 316-318. PMID: 22190377, DOI: 10.1002/hep.24717.Peer-Reviewed Original ResearchCitationsAltmetric
2010
Stem cell therapeutics: potential in the treatment of inflammatory bowel disease
Swenson E, Theise N. Stem cell therapeutics: potential in the treatment of inflammatory bowel disease. Clinical And Experimental Gastroenterology 2010, 3: 1-10. DOI: 10.2147/ceg.s12187482.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseAllogeneic hematopoietic transplantationHematopoietic stem cellsTreatment of inflammatory bowel diseaseHematopoietic transplantationPredisposition to inflammatory bowel diseaseHost immune responseMesenchymal stem cellsStem cellsGenetic predisposition to inflammatory bowel diseaseSystemically infused mesenchymal stem cellsFistulas associated with Crohn's diseaseGraft-versus-host diseaseImmune responseHematopoietic stem cell transplantationBowel diseaseAutologous hematopoietic transplantationGraft-versus-hostStem cell transplantationDownregulate host immune responsesRisk of complicationsStem cell therapyStem cell therapy applicationsAutologous hematopoietic reconstitutionBlood cell linesStem cell therapeutics: potential in the treatment of inflammatory bowel disease
Swenson E, Theise N. Stem cell therapeutics: potential in the treatment of inflammatory bowel disease. Clinical And Experimental Gastroenterology 2010, Volume 3: 1-10. PMID: 21694840, PMCID: PMC3108654, DOI: 10.2147/ceg.s6836.Peer-Reviewed Original ResearchCitationsAltmetricConceptsInflammatory bowel diseaseAllogeneic hematopoietic transplantationHost immune responseHematopoietic transplantationMesenchymal stem cellsBlood cell linesBowel diseaseImmune responseGenetic predispositionStem cellsLarge clinical trialsAutologous hematopoietic transplantationAutologous hematopoietic reconstitutionHost diseaseCrohn's diseaseMucosal immunityClinical trialsHematopoietic reconstitutionSmall seriesTransplantationGreater riskCell therapyDiseaseDonor cellsBaseline state
2009
Adenosine inhibits chemotaxis and induces hepatocyte‐specific genes in bone marrow mesenchymal stem cells
Mohamadnejad M, Sohail MA, Watanabe A, Krause DS, Swenson ES, Mehal WZ. Adenosine inhibits chemotaxis and induces hepatocyte‐specific genes in bone marrow mesenchymal stem cells. Hepatology 2009, 51: 963-973. PMID: 20044808, PMCID: PMC2840188, DOI: 10.1002/hep.23389.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMarrow-derived mesenchymal stem cellsHepatocyte growth factorMSC chemotaxisCellular injuryMesenchymal stem cellsAdenosine concentrationRegulation of HGFInhibition of HGFEffects of adenosineSite of injuryBone marrow-derived mesenchymal stem cellsHepatocyte-specific genesHigh adenosine concentrationsHuman marrow-derived mesenchymal stem cellsAdenosine monophosphateBone marrow mesenchymal stem cellsStem cellsMarrow mesenchymal stem cellsConcentration of adenosineLiver injuryCytosolic calcium signalingStress fiber formationA2A receptorsHepatocyte-like cellsCyclic adenosine monophosphate
2008
Chimeric mice reveal clonal development of pancreatic acini, but not islets
Swenson ES, Xanthopoulos J, Nottoli T, McGrath J, Theise ND, Krause DS. Chimeric mice reveal clonal development of pancreatic acini, but not islets. Biochemical And Biophysical Research Communications 2008, 379: 526-531. PMID: 19116141, PMCID: PMC2657659, DOI: 10.1016/j.bbrc.2008.12.104.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsStem/progenitor cellsMultiple progenitorsAdult mouse small intestineMale ES cellsProgenitor cellsFemale blastocystsCrypt stem cellsClonal descendantsES cellsY chromosomeChimeric miceFemale cellsIntestinal crypt stem cellsExocrine pancreatic aciniFemale epithelial cellsClonal developmentStem cellsSitu hybridizationMouse small intestineEpithelial cellsIntestinal cryptsProgenitorsPancreatic aciniCellsPancreatic isletsHepatocyte Nuclear Factor‐1 as Marker of Epithelial Phenotype Reveals Marrow‐Derived Hepatocytes, but Not Duct Cells, After Liver Injury in Mice
Swenson ES, Guest I, Ilic Z, Mazzeo‐Helgevold M, Lizardi P, Hardiman C, Sell S, Krause DS. Hepatocyte Nuclear Factor‐1 as Marker of Epithelial Phenotype Reveals Marrow‐Derived Hepatocytes, but Not Duct Cells, After Liver Injury in Mice. Stem Cells 2008, 26: 1768-1777. PMID: 18467658, PMCID: PMC2846397, DOI: 10.1634/stemcells.2008-0148.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsMarrow-derived epithelial cellsHepatocyte nuclear factor 1Y chromosomeNuclear factor 1Ductal progenitor cellsLiver injuryInflammatory cellsFemale miceProgenitor cellsEpithelial cellsFactor 1Male bone marrowStable hematopoietic engraftmentBone marrow originColocalization of GFPNuclear markersBone marrow cellsDuctal progenitorsHematopoietic engraftmentChromosomesBone marrowMarrow originPancytokeratin stainingCholangiocyte phenotypeMarrow cells
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