Electrophysiology and 3D‐imaging reveal properties of human intracardiac neurons and increased excitability with atrial fibrillation
Ashton J, Prince B, Sands G, Argent L, Anderson M, Smith J, Tedoldi A, Ahmad A, Baddeley D, Pereira A, Lever N, Ramanathan T, Smaill B, Montgomery J. Electrophysiology and 3D‐imaging reveal properties of human intracardiac neurons and increased excitability with atrial fibrillation. The Journal Of Physiology 2024 PMID: 38687681, DOI: 10.1113/jp286278.Peer-Reviewed Original ResearchInduced action potential firingAction potential firingGP neuronsGanglionated plexiAtrial fibrillationPhenotypic neuronsAF patientsAutonomic neuronsPotential firingWhole cell patch-clamp techniqueAutonomic influencesAction potential firing rateIncreased synaptic densityAction potential accommodationSynaptic densityPatch-clamp techniqueAction potential kineticsOpen heart surgeryEpicardial adipose tissueInitiation of AFAutonomic ganglionated plexiControl of cardiac functionAction potential rateAutonomic nervous systemNoradrenergic phenotype