David A. Alagpulinsa, PhD
Assistant ProfessorDownloadHi-Res Photo
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Comparative Medicine
Primary
Cardiovascular Medicine
Secondary
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About
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Assistant Professor
Biography
David is an Assistant Professor of Comparative and Cardiovascular Medicine. His doctoral studies in Interdisciplinary Biomedical Sciences at the University of Arkansas for Medical Scinces in Little Rock, Arkansas, focused on defining and exploiting the mechanisms that maintain genome integrity in multiple myeloma, a hematologic malignancy of B lymphocytes. He completed a postdoctoral training at the Massachusetts General Hospital and Harvard Medical School in Boston, developing strategies to immunoprotect endogenous and transplanted islets to treat type 1 diabetes without systemic immunosuppression. David joined the Yale Center for Molecular and Systems Metabolism and Department of Comparative Medicine at Yale as an Assistant Professor in 2023 to establish the AlagsLab. Research in the AlagsLab integrates knowledge from genetics, developmental and molecular biology, immunology, biomedical engineering, and statistical and computational biology to understand complex traits and diseases, including hematopoiesis, T1D, and cardiovascular disease.
Appointments
Comparative Medicine
Assistant ProfessorPrimaryCardiovascular Medicine
Assistant ProfessorSecondary
Other Departments & Organizations
- Alagpulinsa Laboratory
- Cardiovascular Medicine
- Comparative Medicine
- Internal Medicine
- Janeway Society
- Molecular Medicine, Pharmacology, and Physiology
- Program in Translational Biomedicine (PTB)
- Vascular Biology and Therapeutics Program
- Yale Center for Molecular and Systems Metabolism (YMSM)
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- YCCEH
Education & Training
- Instructor
- Massachusetts General Hospital & Harvard Medical School (2023)
- Postdoc
- Massachusetts General Hospital & Harvard Medical School (2021)
- PhD
- University of Arkansas for Medical Sciences (2015)
Research
Overview
Medical Subject Headings (MeSH)
Atherosclerosis; Autoimmune Diseases; Cardiovascular Diseases; Clonal Hematopoiesis; Diabetes Mellitus, Type 1; DNA Transposable Elements; Epigenomics; Genetics; Genomics; Hematopoiesis; Hematopoietic Stem Cells; Islets of Langerhans; Myocardial Infarction; Single-Cell Analysis
ORCID
0000-0002-8737-4907- View Lab Website
Alagpulinsa Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of David A. Alagpulinsa's published research.
Publications Timeline
A big-picture view of David A. Alagpulinsa's research output by year.
Georges El Fakhri, PhD, DABR
Moses Quinn Wilks, PhD
14Publications
11Citations
Publications
2024
Genetic relations between type 1 diabetes, coronary artery disease and leukocyte counts.
Adebekun J, Nadig A, Saarah P, Asgari S, Kachuri L, Alagpulinsa DA. Genetic relations between type 1 diabetes, coronary artery disease and leukocyte counts. Diabetologia 2024 PMID: 39141130, DOI: 10.1007/s00125-024-06247-9.Peer-Reviewed Original ResearchAssociation of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV
Schnittman S, Talathi R, Wilks M, Hedgire S, Lu M, Fourman L, Alagpulinsa D, Stockman S, White K, Wallis Z, Autissier P, Stanley T, Lee H, Honigberg M, El-Fakhri G, Williams K, Zanni M, Grinspoon S, Toribio M. Association of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV. AIDS 2024, 38: 1940-1946. PMID: 38905489, DOI: 10.1097/qad.0000000000003967.Peer-Reviewed Original ResearchAltmetricConceptsArterial infiltrationCardiovascular diseaseIncreased risk of cardiovascular diseaseHuman immunodeficiency virusT cell subtypesT lymphocyte subpopulationsRisk of cardiovascular diseaseSystemic monocyte activationCardiovascular disease riskImmunodeficiency virusMonocyte activationHIV statusIncreased riskRelevant to atherogenesisHIVInfiltrationGeneral populationPWHEvidence of interactionSubtypesDiseaseSubpopulationsAtherogenesis
2023
Short-term function and immune-protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non-human primates without systemic immune suppression: A pilot study.
Sremac M, Luo H, Deng H, Parr MFE, Hutcheson J, Verde PS, Alagpulinsa DA, Kitzmann JM, Papas KK, Brauns T, Markmann JF, Lei J, Poznansky MC. Short-term function and immune-protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non-human primates without systemic immune suppression: A pilot study. Xenotransplantation 2023, e12826. PMID: 37712342, DOI: 10.1111/xen.12826.Peer-Reviewed Original ResearchPlasma osteopontin relates to myocardial fibrosis and steatosis and to immune activation among women with HIV.
Robinson JA, Toribio M, Quinaglia T, Awadalla M, Talathi R, Durbin CG, Alhallak I, Alagpulinsa DA, Fourman LT, Suero-Abreu GA, Nelson MD, Stanley TL, Longenecker CT, Szczepaniak LS, Jerosch-Herold M, Neilan TG, Zanni MV, Burdo TH. Plasma osteopontin relates to myocardial fibrosis and steatosis and to immune activation among women with HIV. AIDS 2023, 37: 305-310. PMID: 36541642, DOI: 10.1097/QAD.0000000000003417.Peer-Reviewed Original Research
2022
Cardiac strain is lower among women with HIV in relation to monocyte activation.
Toribio M, Awadalla M, Drobni ZD, Quinaglia T, Wang M, Durbin CG, Alagpulinsa DA, Fourman LT, Suero-Abreu GA, Nelson MD, Stanley TL, Longenecker CT, Burdo TH, Neilan TG, Zanni MV. Cardiac strain is lower among women with HIV in relation to monocyte activation. PLoS One 2022, 17: e0279913. PMID: 36584183, DOI: 10.1371/journal.pone.0279913.Peer-Reviewed Original ResearchAdvances in understanding the molecular basis of clonal hematopoiesis.
Alagpulinsa DA, Toribio MP, Alhallak I, Shmookler Reis RJ. Advances in understanding the molecular basis of clonal hematopoiesis. Trends Mol Med 2022, 28: 360-377. PMID: 35341686, DOI: 10.1016/j.molmed.2022.03.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2021
Metabolomic and transcriptomic analyses of the anti-rheumatoid arthritis potential of xylopic acid in a bioinspired lipoprotein nanoformulation.
Alolga RN, Opoku-Damoah Y, Alagpulinsa DA, Huang FQ, Ma G, Chavez Leon MASC, Kudzai C, Yin X, Ding Y. Metabolomic and transcriptomic analyses of the anti-rheumatoid arthritis potential of xylopic acid in a bioinspired lipoprotein nanoformulation. Biomaterials 2021, 268: 120482. PMID: 33307367, DOI: 10.1016/j.biomaterials.2020.120482.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2020
Genomic Instability in Multiple Myeloma.
Alagpulinsa DA, Szalat RE, Poznansky MC, Shmookler Reis RJ. Genomic Instability in Multiple Myeloma. Trends Cancer 2020, 6: 858-873. PMID: 32487486, DOI: 10.1016/j.trecan.2020.05.006.Peer-Reviewed Original Research
2019
Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma.
Alagpulinsa D, Kumar S, Talluri S, Nanjappa P, Buon L, Chakraborty C, Samur M, Szalat R, Shammas M, Munshi N. Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma. Blood Advances 2019, 3: 3968-3972. PMID: 31805191, PMCID: PMC6963244, DOI: 10.1182/bloodadvances.2019000181.Peer-Reviewed Original ResearchCitationsAltmetricAlginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression.
Alagpulinsa DA, Cao JJL, Driscoll RK, Sîrbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns TA, Markmann JF, Melton DA, Poznansky MC. Alginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression. Am J Transplant 2019, 19: 1930-1940. PMID: 30748094, DOI: 10.1111/ajt.15308.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
activity National Institutes of Health HAI Study Section
Peer Review Groups and Grant Study SectionsAd-hoc reviewerDetails06/15/2023 - Presentactivity Haematologica; American Journal of Transplantation; Trends in Molecular Medicine; Pharmacology & Therapeutics; Frontiers in Cell and Developmental Biology; The FASEB Journal; etc.
Journal ServiceReviewerDetails07/01/2019 - Presenthonor Keystone Fellow
International AwardKeystone SymposiaDetails01/01/2023honor JDRF Diversifying Diabetes Research Talent in Academia Award
National AwardJuvenile Diabetes Research FoundationDetails09/01/2022honor MGH Scientific Advisory Committee on Research Poster of Distinction Award
Other AwardMassachusetts General HospitalDetails04/07/2021
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Sterling Hall of Medicine
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333 Cedar Street
New Haven, CT 06510