Daniel Coman, PhD

I am interested in development of molecular imaging methods to reveal physiological and chemical alterations underlying disease in preclinical models and exploit them in clinical applications. In my lab I use advanced Magnetic Resonance (MR) techniques, from multi-nuclear MR Spectroscopy (¹H, ¹³C, ³¹P, ¹⁹F, ²³Na) to multi-modal MR Imaging (Biosensor Imaging of Redundant Deviation in Shifts - BIRDS, Chemical Exchange Saturation Transfer, calibrated fMRI, Diffusion Tensor Imaging, Arterial Spin Labeling, etc.), to conduct in vivo biomedical imaging research on both pre-clinical and clinical scanners. My research interest is development of new MR imaging biomarkers for cancer, to better understand the resistance mechanisms and design new therapies. For this, I developed an ultrafast MR Spectroscopic Imaging technique called Biosensor Imaging of Redundant Deviation in Shifts (or BIRDS) for mapping the acidic microenvironment of cancer.