Cristina A. Figueroa Villalba, MD
Clinical FellowAbout
Research
Publications
2024
Red Cell Damage During Extracorporeal Life Support.
Figueroa Villalba CA, Saifee NH, Chandler WL. Red Cell Damage During Extracorporeal Life Support. ASAIO J 2024 PMID: 38950201, DOI: 10.1097/MAT.0000000000002265.Peer-Reviewed Original ResearchPuzzling undetectable haptoglobin in a transfused pregnant patient
Chaves Rivera M, Choucair I, Vera M, El-Khoury J, Figueroa Villalba C. Puzzling undetectable haptoglobin in a transfused pregnant patient. Clinica Chimica Acta 2024, 561: 119829. PMID: 38917868, DOI: 10.1016/j.cca.2024.119829.Peer-Reviewed Original ResearchAcute hemolytic transfusion reactionUndetectable haptoglobin levelUndetectable haptoglobinPregnant patientsHaptoglobin levelsB-cell acute lymphocytic leukemiaPregnancy-related physiological changesTrimester-specific reference intervalsReference intervalsCenters for Disease Control (CDC) criteriaDiagnosis of hemolysisNon-pregnant counterpartsTrimester of pregnancyAcute lymphocytic leukemiaHemolytic transfusion reactionsMultidisciplinary approach to patient careFollow-up visitRed cell unitsLactate dehydrogenasePhysiological changesRBC transfusionThird trimesterLymphocytic leukemiaLaboratory findingsImmunological markersThrombosis risk with haemoglobin C trait and haemoglobin C disease: A systematic review
Jacobs J, Sharma D, Stephens L, Villalba C, Rinder H, Woo J, Wheeler A, Gerberi D, Goel R, Tormey C, Booth G, Bloch E, Adkins B. Thrombosis risk with haemoglobin C trait and haemoglobin C disease: A systematic review. British Journal Of Haematology 2024, 204: 1500-1506. PMID: 38291731, DOI: 10.1111/bjh.19313.Peer-Reviewed Original ResearchRisk of thrombosisHemoglobin C traitHemoglobin C diseaseVenous thromboembolismC diseaseIncreased risk of thrombosisProspective cohort studyFactor to thrombosisAssessment of patientsCohort studySystematic reviewInclusion criteriaPregnant individualsThrombotic riskCase seriesCase reportVTE riskChronic haemolysisSystematic literature reviewArterial thrombosisThrombosis riskHigh blood viscosityIncreased riskThrombosisC trait
2023
Challenges in recognising paroxysmal cold hemoglobinuria.
Jacobs JW, Booth GS, Woo JS, Stephens LD, Figueroa Villalba CA, Adkins BD. Challenges in recognising paroxysmal cold hemoglobinuria. Transfus Med 2023 PMID: 38151804, DOI: 10.1111/tme.13024.Peer-Reviewed Original ResearchHeidenhain variant of Creutzfeldt-Jakob disease masquerading as neuromyelitis optica spectrum disorder: recognizing when apheresis is not the answer
Burke O, Jacobs J, Tormey C, Rinder H, Villalba C, Lee E, Campos J, Abels E, Yurtsever N. Heidenhain variant of Creutzfeldt-Jakob disease masquerading as neuromyelitis optica spectrum disorder: recognizing when apheresis is not the answer. Lab Medicine 2023, 55: 520-523. PMID: 38142129, DOI: 10.1093/labmed/lmad107.Peer-Reviewed Original ResearchNeuromyelitis optica spectrum disorderCreutzfeld-Jakob diseaseOptica spectrum disorderHeidenhain variantBilateral vision lossTherapeutic plasma exchangeReal-time quaking-induced conversionCreutzfeldt-Jakob diseaseImmunosuppressive therapyVisual disturbancesPlasma exchangeNeurocognitive symptomsTreatment modalitiesVision lossHospice careSpectrum disorderRare formPreliminary diagnosisDiseaseDiagnosisDisordersEarly stagesPatientsApheresisTherapyImmunity in the balance: Fatal disseminated adenovirus infection in a patient undergoing plasma exchange and immunosuppressive chemotherapy for anti‐glomerular basement membrane disease
Jacobs J, Villalba C, Stendahl K, Tormey C, Abels E. Immunity in the balance: Fatal disseminated adenovirus infection in a patient undergoing plasma exchange and immunosuppressive chemotherapy for anti‐glomerular basement membrane disease. Journal Of Clinical Apheresis 2023, 38: 770-777. PMID: 37698143, DOI: 10.1002/jca.22088.Peer-Reviewed Original ResearchConceptsTherapeutic plasma exchangeAnti-glomerular basement membrane diseaseAnti-GBM diseasePlasma exchangeMembrane diseaseDaily therapeutic plasma exchangeFatal disseminated adenovirus infectionRare autoinflammatory conditionsMulti-organ failureStandard therapeutic regimenDisseminated adenovirus infectionDisseminated adenovirus diseasePotential opportunistic infectionsPotential adverse effectsApheresis guidelinesAdenovirus diseaseOrgan inflammationProfound immunosuppressionAutoantibody productionOpportunistic infectionsTherapeutic regimenAutoinflammatory conditionsImmunosuppressive chemotherapyUnusual infectionsClose surveillanceHemolysis or wine? A case of red-wine-colored plasma
Malaeb H, Vera M, Figueroa Villalba C, El-Khoury J. Hemolysis or wine? A case of red-wine-colored plasma. Clinica Chimica Acta 2023, 542: 117277. PMID: 36870523, DOI: 10.1016/j.cca.2023.117277.Peer-Reviewed Original ResearchClinical and Epidemiological Features of Paroxysmal Cold Hemoglobinuria: A Systematic Review.
Jacobs JW, Figueroa Villalba CA, Booth GS, Woo JS, Stephens LD, Adkins BD. Clinical and Epidemiological Features of Paroxysmal Cold Hemoglobinuria: A Systematic Review. Blood Adv 2023 PMID: 36716137, DOI: 10.1182/bloodadvances.2022009516.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use
Choucair I, Villalba C, Vera M, Cassella-Mclane G, Durant T, El-Khoury J. A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use. Clinical Biochemistry 2022, 112: 6-10. PMID: 36535386, DOI: 10.1016/j.clinbiochem.2022.12.009.Peer-Reviewed Original ResearchConceptsConcentrations of hydrocodoneMean ratioOxycodone pillsPrescription complianceOpioid useUDT resultsMedication recordsOxycodoneAdditional opiatesPatientsHydromorphoneLarger sample sizeAbstractTextHydrocodoneDrug abuseLiquid chromatography-tandem mass spectrometryDrug testingChromatography-tandem mass spectrometryLC-MS/MSFurther validationPreliminary studySample sizeOpiatesSensitive methodPillsAlloimmunization following antigen‐negative red blood cell transfusion
Jacobs J, Binns T, Abels E, Iyer K, Villalba C, Verma A, Sostin N, Tormey C. Alloimmunization following antigen‐negative red blood cell transfusion. Transfusion 2022, 63: 430-434. PMID: 36458330, DOI: 10.1111/trf.17208.Peer-Reviewed Case Reports and Technical NotesConceptsTransfusion of RBCsRed blood cell transfusionRed blood cell alloimmunizationPrevious antigen exposureBlood cell transfusionAlloantibody specificitiesCell transfusionRBC transfusionAntigen exposureRBC alloantibodiesAntigenic stimulusDetectable titersAntigenic stimulationMyeloid neoplasmsTransfusionAlloantibodiesAlloimmunizationParticular antigenPrior exposureStimulatory eventsExact mechanismCorresponding antibodiesRBCsExposurePregnancy