Christopher Whitlow, MD, PhD, MHA
Chair, Department of Radiology and Biomedical ImagingAbout
Research
Publications
2025
Predicting Immunotherapy-Induced Pneumonitis Based on Chest CT and Non-Imaging Data
Lyu Q, Yuan H, Lin Z, Ponnatapura J, Whitlow C. Predicting Immunotherapy-Induced Pneumonitis Based on Chest CT and Non-Imaging Data. Cancers 2025, 17: 2980. PMID: 41008824, PMCID: PMC12468472, DOI: 10.3390/cancers17182980.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsICI-pneumonitisCT scanTreatment of non-small cell lung cancer patientsComputed tomographyNon-small cell lung cancer patientsRisk of developing pneumonitisCell lung cancer patientsHigh riskICI-based immunotherapyImmunotherapy-induced pneumonitisEarly identification of patientsSignificant survival benefitScreening computed tomographyEarly identificationIdentification of patientsReceiver operating characteristic curveArea under the receiver operating characteristic curveLung cancer patientsOperating characteristics curveCheckpoint inhibitorsChest CTSurvival benefitClinical featuresClinical dataStructural Alterations in the Gray Matter Volume in Rapid‐Onset Dystonia‐Parkinsonism
Haq I, Simonyan K, Napoli E, Ozelius L, Snively B, Whitlow C, Sweadner K, Brashear A. Structural Alterations in the Gray Matter Volume in Rapid‐Onset Dystonia‐Parkinsonism. Movement Disorders 2025 PMID: 40888012, DOI: 10.1002/mds.30320.Peer-Reviewed Original ResearchGray matter volumeMatter volumeWhole-brain gray matter volumeRight inferior temporal cortexStructural magnetic resonance imaging dataGray matter volume changesExecutive brain regionsPrefrontal cortical volumeRDP patientsInferior parietal cortexRight prefrontal cortexInferior temporal cortexParkinson's diseaseBilateral caudate nucleusMagnetic resonance imaging dataThalamic blood flowPrefrontal cortexFusiform gyrusTemporal cortexParietal cortexBrain regionsCaudate nucleusCortical volumeMatter organizationRapid-onset dystonia-parkinsonismGenomic Signature to Predict Neurologic Death in Non-Small Cell Lung Cancer Patients
Glynn S, Lanier C, Choi A, D'Agostino R, Farris M, Abdulhaleem M, Wang Y, Smith M, Ruiz J, Lycan T, Petty W, Cramer C, Tatter S, Laxton A, White J, Su J, Whitlow C, Xing F, Chan M, Helis C. Genomic Signature to Predict Neurologic Death in Non-Small Cell Lung Cancer Patients. International Journal Of Radiation Oncology • Biology • Physics 2025, 123: e264-e265. DOI: 10.1016/j.ijrobp.2025.06.2116.Peer-Reviewed Original ResearchNon-small cell lung cancerNon-small cell lung cancer patientsRisk of neurological deathBrain metastasesLow-risk groupNeurological deathNon-neurologic deathRisk groupsHazard ratioNext-generation sequencingRisk scoreCumulative incidenceCumulative incidences of neurological deathAssociated with neurological deathIncidence of neurologic deathCell lung cancer patientsHigh riskNext-generation sequencing panelSystemic therapy regimensAggressive local therapyCell lung cancerNon-invasive liquid biopsyModerate risk groupProportional hazards regression modelsProgressive neurological dysfunctionOptimizing Blood-Based Genomic Characterization of Oligometastatic Non-Small Cell Lung Cancer Patients
Choi A, Lanier C, Glynn S, Young P, D'Agostino R, Farris M, Abdulhaleem M, Wang Y, Ruiz J, Lycan T, Petty W, Cramer C, Tatter S, Laxton A, White J, Li W, Su J, Whitlow C, Xing F, Chan M. Optimizing Blood-Based Genomic Characterization of Oligometastatic Non-Small Cell Lung Cancer Patients. International Journal Of Radiation Oncology • Biology • Physics 2025, 123: s199-s200. DOI: 10.1016/j.ijrobp.2025.07.1291.Peer-Reviewed Original ResearchNon-small cell lung cancerOligometastatic non-small cell lung cancerCohort of NSCLC patientsHigh-risk scoreNSCLC patientsOverall survivalLow-risk scoresOligometastatic diseaseBrain metastasesRisk scoreCumulative incidenceValidation cohortManagement of oligometastatic non-small cell lung cancerNon-small cell lung cancer patientsHazard ratioCell lung cancer patientsExtracranial oligometastatic diseaseInstitutional patient databaseCirculating tumor DNACell lung cancerCox regression analysisMantel-Haenszel chi-square testFisher's exact testLung cancer patientsOligometastatic phenotypePrediction of Oligometastatic Disease from Breast Cancer Using Next Generation Sequencing Genomics
Young P, Choi A, Hunting J, Ormond S, Wang Y, Douglas E, Ansley K, Cramer C, Li W, Whitlow C, Xing F, Soto-Pantoja D, Ruiz J, Chan M. Prediction of Oligometastatic Disease from Breast Cancer Using Next Generation Sequencing Genomics. International Journal Of Radiation Oncology • Biology • Physics 2025, 123: e233-e234. DOI: 10.1016/j.ijrobp.2025.06.3806.Peer-Reviewed Original ResearchOligometastatic diseaseOligometastatic progressionBreast cancerRisk scoreNext generation sequencingCumulative incidenceWidespread progressionWidespread diseaseMetastatic breast cancerFisher's exact testMetastatic diseaseChi-square testExtracranial diseaseDiffuse involvementWald chi-square testExact testCox regressionPatientsMedical recordsElectronic medical recordsStandard panelCancerPatients' scoresDiseaseSequenced genomesThe differential relationship between white matter cerebrovascular perfusion and microstructure between normal cognition and mild cognitive impairment.
Kim D, Yoon S, Hughes T, Wu Y, Harvey D, Lipford M, Lockhart S, Craft S, Baker L, Whitlow C, Okonmah-Obazee S, Hugenschmidt C, Bobinski M, Jung Y. The differential relationship between white matter cerebrovascular perfusion and microstructure between normal cognition and mild cognitive impairment. Journal Of Alzheimer’s Disease 2025, 13872877251360740. PMID: 40717441, DOI: 10.1177/13872877251360740.Peer-Reviewed Original ResearchNormal-appearing white matterIntracellular volume fractionCerebrovascular reactivityCerebrovascular perfusionArterial transit timeLow cerebrovascular reactivityNormal cognitionCerebral blood flowMagnetic resonance imagingCognitive impairmentIsotropic volume fractionVascular risk factorsVoxel-wise analysisGlycemic statusOrientation dispersion indexProlonged arterial transit timeRisk factorsImaging biomarkersResonance imagingBlood flowPerfusionMultiple MRI measuresWhite matterMRI measurementsMild cognitive impairmentClinical Role of Brain PET in Alzheimer Disease in the Era of Disease-Modifying Therapies.
Franceschi A, Keir G, Benzinger T, Cogswell P, Ali F, Petrella J, Prescott J, Whitlow C, Zaharchuk G, Allen J. Clinical Role of Brain PET in Alzheimer Disease in the Era of Disease-Modifying Therapies. American Journal Of Neuroradiology 2025, 46: 1521-1527. PMID: 40639970, PMCID: PMC12453502, DOI: 10.3174/ajnr.a8738.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAlzheimer's dementia todayPathophysiology of ADEffective patient careCause of dementiaClinical practiceEarly-stage Alzheimer's diseaseWorkforce capacityOlder livingDementia todayAmyloidClinical roleDementia progressionPatient carePET imagingMonoclonal antibody therapyNeurodegenerative diseasesEra of disease-modifying therapiesFood and Drug AdministrationAbnormal accumulationAlzheimerDisease-modifying therapiesMonitoring of patientsDisease biomarkersAntibody therapyEvaluation of plasma p‐tau217 for detecting amyloid pathology in a heterogeneous community‐based cohort
Rudolph M, Sutphen C, Register T, Lockhart S, Rundle M, Hughes T, Bateman J, Sai K, Whitlow C, Craft S, Mielke M. Evaluation of plasma p‐tau217 for detecting amyloid pathology in a heterogeneous community‐based cohort. Alzheimer's & Dementia 2025, 21: e70426. PMID: 40613474, PMCID: PMC12231229, DOI: 10.1002/alz.70426.Peer-Reviewed Original ResearchConceptsAlzheimer's Disease Research CenterCommunity-based cohortMild cognitive impairmentPlasma p-tau217Amyloid pathologyCognitively unimpaired participantsP-tau217Positron emission tomographyBlack participantsLogistic regressionHeterogeneous cohortUnimpaired participantsCognitive impairmentParticipantsCohortDementiaAmyloid positron emission tomographyCutpointsReceiver operating curve analysisP-tau217 levelsPublished thresholdsAmyloidResearch CenterOperating Curve analysisMild to moderate kidney diseaseMRI-Based Radiomics Ensemble Model for Predicting Radiation Necrosis in Brain Metastasis Patients Treated with Stereotactic Radiosurgery and Immunotherapy
Chen Y, Helis C, Cramer C, Munley M, Choi A, Tan J, Xing F, Lyu Q, Whitlow C, Willey J, Chan M, Jiang Y. MRI-Based Radiomics Ensemble Model for Predicting Radiation Necrosis in Brain Metastasis Patients Treated with Stereotactic Radiosurgery and Immunotherapy. Cancers 2025, 17: 1974. PMID: 40563624, PMCID: PMC12191015, DOI: 10.3390/cancers17121974.Peer-Reviewed Original ResearchArea under the curveRadiation necrosisNegative predictive valuePositive predictive valueBrain metastasesConclusions:Occurrence of radiation necrosisRadiomic featuresPredictive valueResults:SRS sessionBrain metastasis patientsHighest area under the curveMethod:Radiosurgery sessionStereotactic radiosurgeryRadiation therapyMetastasis patientsTreatment modalitiesValidation cohortClinical factorsNeurological deficitsMetastasisClinical informationNecrosisCorrelating Magnetoencephalography, Diffusion Kurtosis Imaging, Biomechanics, and Neuropsychology in American Youth Football
Bell N, Yu F, Xi Y, Proskovec A, Holcomb J, Chilukuri S, Urban J, Vaughan C, DeSimone J, Wagner B, Espeland M, Powers A, Whitlow C, Stitzel J, Maldjian J, Davenport E. Correlating Magnetoencephalography, Diffusion Kurtosis Imaging, Biomechanics, and Neuropsychology in American Youth Football. Journal Of Neurotrauma 2025, 42: 1302-1318. PMID: 40329815, PMCID: PMC12411097, DOI: 10.1089/neu.2024.0222.Peer-Reviewed Original ResearchConceptsRepetitive head impactsDiffusion kurtosis imagingFootball playersStatistically significant positive associationRepetitive head impact exposureKurtosis imagingExposure to repetitive head impactsYouth football playersSignificant positive associationVoxel-wise differencesZ-score mapsNeuropsychological dataNeuropsychological changesNeuroimaging metricsYouth footballMultimodal neuroimagingNeurophysiological alterationsAged 8Exposure metricsZ-scorePositive associationPsychological dataHead impactsMagnetoencephalographyLinear regression