Christopher Radcliffe, MD
Clinical FellowAbout
Research
Publications
2025
Vaccination strategies for solid organ transplant candidates and recipients: insights and recommendations.
Radcliffe C, Kotton CN. Vaccination strategies for solid organ transplant candidates and recipients: insights and recommendations. Expert Rev Vaccines 2025, 24: 313-323. PMID: 40184037, DOI: 10.1080/14760584.2025.2489659.Peer-Reviewed Original ResearchBellini and Balloon Pumps: Art in the Cardiac Intensive Care Unit
Christopher V Radcliffe MD , David M Dudzinski MD JD , Bellini and Balloon Pumps: Art in the Cardiac Intensive Care Unit, Journal of Cardiac Failure - Intersections (2025), doi: https://doi.org/10.1016/j.yjcafi.2025.10.015Peer-Reviewed Original ResearchLactobacillus Bacteremia and Endovascular Infections: A Retrospective Study of 100 Patients.
Radcliffe CV, Anahtar MN, Hohmann EL, Turbett SE, Dugdale CM, Paras ML. Lactobacillus Bacteremia and Endovascular Infections: A Retrospective Study of 100 Patients. Open Forum Infect Dis 2025, 12: ofaf466. PMID: 40852136, DOI: 10.1093/ofid/ofaf466.Peer-Reviewed Original Research
2024
Experience with expanded use of oritavancin in a tertiary hospital: indications, tolerability and outcomes
Bandaranayake T, Radcliffe C, Cvercko M, Golden M, Hao R. Experience with expanded use of oritavancin in a tertiary hospital: indications, tolerability and outcomes. JAC-Antimicrobial Resistance 2024, 6: dlae174. PMID: 39493938, PMCID: PMC11524893, DOI: 10.1093/jacamr/dlae174.Peer-Reviewed Original ResearchDose of oritavancinInfective endocarditisTreatment of acute bacterial skinBacterial infectionsLipoglycopeptide antibacterial agentTertiary care medical centreAcute bacterial skinGram-positive bacterial infectionsInvasive bacterial infectionsTreatment failure rateNinety-five adult patientsSoft tissue infectionsProsthetic joint infectionGram-positive organismsBacterial skinDrug discontinuationTissue infectionsRetrospective studyAdult patientsClinical outcomesAdverse eventsOritavancinOff-labelJoint infectionTreat infectionsTravel Medicine for Immunocompromised Travelers: An Essential Layer of Protection
Radcliffe C, Kotton CN. Travel medicine for immunocompromised travelers: An essential layer of protection. Curr Treat Options Infect Dis. 2025;17(2). doi: 10.1007/s40506-024-00277-yPeer-Reviewed Original ResearchEn Garde or On Board? Travel Medicine for Immunocompromised Patients in the COVID-19 Era.
Radcliffe C, Kotton CN. En Garde or On Board? Travel Medicine for Immunocompromised Patients in the COVID-19 Era. Ann Intern Med 2024, 177: 667-669. PMID: 38588541, DOI: 10.7326/M24-0256.Peer-Reviewed Original Research
2023
Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging
Kumar A, Wang J, Esterly A, Radcliffe C, Zhou H, Wyk B, Allore H, Tsang S, Barakat L, Mohanty S, Zhao H, Shaw A, Zapata H. Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging. Aging 2023, 15: 7866-7908. PMID: 37606991, PMCID: PMC10497004, DOI: 10.18632/aging.204927.Peer-Reviewed Original ResearchConceptsDectin-1 stimulationDendritic cellsHIV-positive older adultsOlder adultsDectin-1 functionDistinct immune signaturesDistinct inflammatory signatureMonocytes of HIVCohort of HIVIFN-α productionPro-inflammatory environmentIFN-γ responsesPro-inflammatory phenotypeInnate immune receptorsDistinct gene signaturesStimulation of monocytesInflammatory signatureImmune signaturesHIV infectionIL-12Macrophage signatureCytokine productionIL-6Cytokine increaseHIV
2022
Antiviral Treatment of Coronavirus Disease-2019 Pneumonia
Radcliffe C, Malinis M, Azar M. Antiviral Treatment of Coronavirus Disease-2019 Pneumonia. Clinics In Chest Medicine 2022, 44: 279-297. PMID: 37085220, PMCID: PMC9701636, DOI: 10.1016/j.ccm.2022.11.008.Peer-Reviewed Original ResearchConceptsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSyndrome coronavirus 2 infectionCoronavirus diseaseCoronavirus 2 infectionDirect acting antiviralsAdditional clinical trialsReal-world studyCOVID-19Acting antiviralsAntiviral treatmentTherapeutic optionsAvailable therapiesClinical trialsDisease progressionInpatient treatmentHigh riskEarly pandemicMonoclonal antibodiesDiseaseTreatmentMorbidityPandemicPneumoniaOutpatientsReal-world assessment of the clinical utility of whole body 18F-FDG PET/CT in the diagnosis of infection.
Medvedeva N, Radcliffe C, Malinis M, Chen M, Azar M. Real-world assessment of the clinical utility of whole body 18F-FDG PET/CT in the diagnosis of infection. PLOS ONE 2022, 17: e0277403. PMID: 36374789, PMCID: PMC9662742, DOI: 10.1371/journal.pone.0277403.Peer-Reviewed Original ResearchConceptsPET/CTClinical impactFDG PET/CTRetrospective chart reviewEmission tomography/Evaluation of infectionDiagnosis of infectionVariety of syndromesInfectious indicationsChart reviewCommon indicationTomography useUnknown etiologyEndovascular infectionTomography/Antimicrobial managementClinical indicationsReal-world assessmentInclusion criteriaClinical utilityPatientsTreatment managementUnknown originInfectionCTReal-world experience with available, outpatient COVID-19 therapies in solid organ transplant recipients during the omicron surge
Radcliffe C, Palacios CF, Azar MM, Cohen E, Malinis M. Real-world experience with available, outpatient COVID-19 therapies in solid organ transplant recipients during the omicron surge. American Journal Of Transplantation 2022, 22: 2458-2463. PMID: 35583664, PMCID: PMC9348251, DOI: 10.1111/ajt.17098.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsOral antiviral agentsOrgan transplant recipientsOutpatient therapyTransplant recipientsAntiviral agentsCOVID-19-related morbidityMonoclonal antibodiesKidney transplant recipientsRate of hospitalizationCOVID-19 therapyReal-world effectivenessSARS-CoV-2 pandemicCOVID-19 diagnosisModerate diseaseRetrospective reviewMean ageOutpatient settingClinical trialsSubstantial burdenTherapyCoronavirus diseaseMean timeHealthcare systemReal-world experience