Christopher A Baker, PhD
Associate Research ScientistCards
About
Research
Publications
Featured Publications
Cellular resolution circuit mapping with temporal-focused excitation of soma-targeted channelrhodopsin.
Baker CA, Elyada YM, Parra A, Bolton MM. Cellular resolution circuit mapping with temporal-focused excitation of soma-targeted channelrhodopsin. ELife 2016, 5 PMID: 27525487, PMCID: PMC5001837, DOI: 10.7554/eLife.14193.Peer-Reviewed Original ResearchSparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex
Seeman SC, Campagnola L, Davoudian PA, Hoggarth A, Hage TA, Bosma-Moody A, Baker CA, Lee JH, Mihalas S, Teeter C, Ko AL, Ojemann JG, Gwinn RP, Silbergeld DL, Cobbs C, Phillips J, Lein E, Murphy G, Koch C, Zeng H, Jarsky T. Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex. ELife 2018, 7: e37349. PMID: 30256194, PMCID: PMC6158007, DOI: 10.7554/elife.37349.Peer-Reviewed Original ResearchConceptsRecurrent excitatory connectivityExcitatory connectivityAdult mouse primary visual cortexMouse primary visual cortexHuman cortexLayer 2/3 neuronsClasses of neuronsPrimary visual cortexShort-term depressionBody of evidenceExcitatory neuronsAdult miceVisual cortexSynaptic signalingTwo-photon optogeneticsCell classesCortical networksCortical microcircuitsCortexNeuronsFuture studiesMiceMicrocircuitsSynapsesSynaptic connectivity to L2/3 of primary visual cortex measured by two-photon optogenetic stimulation.
Hage TA, Bosma-Moody A, Baker CA, Kratz MB, Campagnola L, Jarsky T, Zeng H, Murphy GJ. Synaptic connectivity to L2/3 of primary visual cortex measured by two-photon optogenetic stimulation. Elife 2022, 11 PMID: 35060903, DOI: 10.7554/eLife.71103.Peer-Reviewed Original ResearchPaclitaxel effects on axonal localization and vesicular trafficking of NaV1.8
Baker C, Tyagi S, Higerd-Rusli G, Liu S, Zhao P, Dib-Hajj F, Waxman S, Dib-Hajj S. Paclitaxel effects on axonal localization and vesicular trafficking of NaV1.8. Frontiers In Molecular Neuroscience 2023, 16: 1130123. PMID: 36860665, PMCID: PMC9970094, DOI: 10.3389/fnmol.2023.1130123.Peer-Reviewed Original ResearchChemotherapy-induced peripheral neuropathyDorsal root gangliaPTX treatmentDRG axonsEffect of paclitaxelVoltage-gated sodium channel NaPain syndromePeripheral neuropathyDRG neuronsSodium channel NaRoot gangliaCell cycle arrestNeuronal somataSensory neuronsSide effectsTherapeutic targetingTumor growthPaclitaxel effectAntineoplastic agentsAxonal localizationPaclitaxelNumber of NaAxonal compartmentAxonsChannel NaUnique inflammatory RNA profiles of microglia in Creutzfeldt–Jakob disease
Baker CA, Manuelidis L. Unique inflammatory RNA profiles of microglia in Creutzfeldt–Jakob disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 675-679. PMID: 12525699, PMCID: PMC141055, DOI: 10.1073/pnas.0237313100.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseMyeloid cellsUninfected microgliaInflammatory pathwaysMicroglial cellsIFN-gammaInflammatory stimuliMicrogliaInflammatory genesProtein pathologyInfectious agentsPreclinical diagnosisNeurodegenerative diseasesTransmissible spongiformDiseaseBrainPrP amyloidRNA profilesExpression profilesCellsCDNA arraysPrevious studiesInfectionDiagnosisPathologyNeuroimmune pathophysiology of long COVID
Moen J, Baker C, Iwasaki A. Neuroimmune pathophysiology of long COVID. Psychiatry And Clinical Neurosciences 2025, 79: 514-530. PMID: 40536011, PMCID: PMC12247276, DOI: 10.1111/pcn.13855.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSARS-CoV-2 infectionNeuroimmune interactionsNeurological symptomsPost-acute symptoms of COVID-19Manifestations of SARS-CoV-2 infectionNeurological manifestations of SARS-CoV-2 infectionLong COVIDDevelopment of therapiesInfection syndromeChemosensory dysfunctionLong-term symptomsSymptoms of COVID-19Neuroimmune mechanismsPeripheral neuropathyAcute infectionNeuroimmune crosstalkNeurological manifestationsAnimal modelsAutopsy studiesPost-acute symptomsRespiratory illnessPersistent long-term symptomsNervous systemSARS-CoV-2Infection
2026
Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes.
Bhagchandani SH, Ehrenzeller S, Pires IS, Chaudhary N, Booth CJ, Kwon DI, Koutsioumpa C, Baker CA, Laxton C, Santos Guedes de Sá K, Matthews C, Gill P, Li S, Olszowka A, Hudak A, Fischer S, Bayarri-Olmos R, Hooper WB, Iwasaki A. Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes. Sci Immunol 2026, 11: eaea6419. PMID: 42319912, DOI: 10.1126/sciimmunol.aea6419.Peer-Reviewed Original ResearchThis study investigates a novel vaccine strategy using BEACONs, a mucosal adjuvant, to enhance localized immunity and protect against genital herpes by boosting tissue-resident T cells and antibodies.
2024
Real-time imaging of axonal membrane protein life cycles
Tyagi S, Higerd-Rusli G, Akin E, Baker C, Liu S, Dib-Hajj F, Waxman S, Dib-Hajj S. Real-time imaging of axonal membrane protein life cycles. Nature Protocols 2024, 19: 2771-2802. PMID: 38831222, PMCID: PMC11721981, DOI: 10.1038/s41596-024-00997-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMembrane proteinsRecycling of membrane proteinsProtein subcellular localizationMembrane protein homeostasisMembrane protein traffickingEngineered membrane proteinsMultiple membrane proteinsSelf-labeling tagsCell culturesProtein traffickingProtein tagsSubcellular localizationProtein homeostasisSpatiotemporal regulationCellular processesMultiple proteinsSubcellular distributionVesicular packagingThroughput mannerProteinNeuronal compartmentsDistal axonsProtein spatial organizationFluorescent labelingNeuronal culturesBeyond antiviral: role of IFN-I in brain development
Baker C, Iwasaki A. Beyond antiviral: role of IFN-I in brain development. Trends In Immunology 2024, 45: 322-324. PMID: 38644134, DOI: 10.1016/j.it.2024.04.004.Commentaries, Editorials and LettersSpying on specific splicing in spinal nerve injury.
Baker CA. Spying on specific splicing in spinal nerve injury. Neurotherapeutics 2024, 21: e00315. PMID: 38216398, DOI: 10.1016/j.neurot.2024.e00315.Commentaries, Editorials and Letters
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New Haven, CT 06510
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