Changin Oh, PhD, DVM
Associate Research Scientist in GeneticsCards
About
Research
Publications
2025
A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity
Fang Z, Monteiro V, Oh C, Janabi K, Romero L, Ahsan N, Yang L, Peng L, DiMaio D, Lucas C, Chen S. A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity. Nature Biomedical Engineering 2025, 1-16. PMID: 40855125, DOI: 10.1038/s41551-025-01478-6.Peer-Reviewed Original ResearchModular vaccine platformCell surface translocationImmune responseMpox virusVaccine platformMRNA vaccinesVaricella zoster virus glycoproteinLethal viral challengeDevelopment of mRNA vaccinesInsufficient immune responseAntigen expressionProteins E6Surface expressionMRNA immunogenicityMultiple cell linesViral challengeAntigenMultiple antigensCell linesAntigenic epitopesChimeric antigenVirus glycoproteinImmunogenicityMRNASurface translocationRottlerin inhibits macropinocytosis of Porcine Reproductive and Respiratory Syndrome Virus through the PKCδ-Cofilin signaling pathway
Kang Y, Choi J, Lee J, Park S, Oh C. Rottlerin inhibits macropinocytosis of Porcine Reproductive and Respiratory Syndrome Virus through the PKCδ-Cofilin signaling pathway. PLOS ONE 2025, 20: e0324500. PMID: 40392868, PMCID: PMC12091787, DOI: 10.1371/journal.pone.0324500.Peer-Reviewed Original ResearchConceptsRespiratory syndrome virusPorcine ReproductiveLIM domain kinase 1Actin dynamicsPRRSV replicationPRRSV entryPRRSVSignaling pathwayDecreased actin polymerizationActin polymerizationCofilin activityEffects of rottlerinHost cellsKinase 1Enveloped virusesRottlerin treatmentInhibit viral replicationAntiviral moleculesReplicationRottlerinVirusMacropinocytosisEntry pathwayViral replicationPathway
2023
Sequence-independent activity of a predicted long disordered segment of the human papillomavirus type 16 L2 capsid protein during virus entry
Oh C, Buckley P, Choi J, Hierro A, DiMaio D. Sequence-independent activity of a predicted long disordered segment of the human papillomavirus type 16 L2 capsid protein during virus entry. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2307721120. PMID: 37819982, PMCID: PMC10589650, DOI: 10.1073/pnas.2307721120.Peer-Reviewed Original ResearchConceptsAmino acid sequenceAcid sequenceProtein segmentsVirus traffickingUnrelated cellular proteinsSequence-independent mannerIntracellular virus traffickingActivity of proteinsAmino acid segmentComplex biological functionsVirus entryTandem arraysProtein functionTrafficking factorsCellular proteinsEndosome membraneBiological functionsHPV16 pseudovirus infectionCellular factorsDiverse sequencesL2 capsid proteinsRottlerin-Liposome Inhibits the Endocytosis of Feline Coronavirus Infection
Choi J, Jung S, Choi I, Kang Y, Lee D, Lee S, Park S, Song C, Choi I, Lee J, Oh C. Rottlerin-Liposome Inhibits the Endocytosis of Feline Coronavirus Infection. Veterinary Sciences 2023, 10: 380. PMID: 37368766, PMCID: PMC10302841, DOI: 10.3390/vetsci10060380.Peer-Reviewed Original ResearchFeline infectious peritonitisFeline coronavirus infectionSystemic granulomatous inflammationDose-dependent mannerFCoV replicationGranulomatous inflammationAntiviral effectInfectious peritonitisPotential treatmentFatal diseaseHigh mortalityCoronavirus infectionFeline coronavirusAntiviral propertiesWorth further investigationFurther investigationCellular levelFCoV.Inhibition efficacyPeritonitisInflammationRottlerinLater stages
2021
Inhibition of endocytosis of porcine reproductive and respiratory syndrome virus by rottlerin and its potential prophylactic administration in piglets
Kang Y, Oh C, Ahn S, Choi J, Choi H, Lee S, Choi I, Song C, Lee J, Park S. Inhibition of endocytosis of porcine reproductive and respiratory syndrome virus by rottlerin and its potential prophylactic administration in piglets. Antiviral Research 2021, 195: 105191. PMID: 34678331, DOI: 10.1016/j.antiviral.2021.105191.Peer-Reviewed Original ResearchConceptsAnti-PRRSV effectPRRSV infectionBlood viral loadRespiratory syndrome virusInterstitial pneumoniaProphylactic administrationClinical scoresViral loadProphylactic treatmentAntiviral effectAntiviral agentsPRRSV internalizationViral replicationUntreated pigsProtein kinase CTreatmentΔ phosphorylationEntry pathwayInfectionInhibition of endocytosisRottlerinKinase CLimited studiesVivoPigs
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