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INFORMATION FOR

    Arman Fesharaki-Zadeh, MD, PhD, BMath

    Assistant Professor of Psychiatry and of Neurology
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    Additional Titles

    Medical Director, Dementia and Behavioral Neurology, Neurology

    Program Co-Director, Behavioral Neurology and Neuropsychiatry Fellowship, Neurology

    About

    Titles

    Assistant Professor of Psychiatry and of Neurology

    Medical Director, Dementia and Behavioral Neurology, Neurology; Program Co-Director, Behavioral Neurology and Neuropsychiatry Fellowship, Neurology

    Biography

    Dr. Fesharaki is currently a neuropsychiatrist, as well as a basic neuroscience researcher focusing on Traumatic Brain Injury and Chronic Traumatic Encephalopathy. He has a diverse training background, which include a mixture of clinical adult psychiatry, clinical behavioral neurology/neuropsychiatry and bench neuroscience skills. This combination of aforementioned skills has in turn given him a unique vantage point to have the opportunity to apply what he continues to learn in the laboratory to enrich his clinical treatment. His current research focus is to develop a robust animal model of Chronic Traumatic Encephalopathy (CTE), as well as investigation of potential treatment modalities. He is also involved in a collaborative research study investigating synaptic density alterations in behavioral variant frontotemporal dementia (bvFTD).

    Last Updated on April 07, 2025.

    Appointments

    Other Departments & Organizations

    Education & Training

    PhD
    SUNY Downstate Medical Center, Neuroscience (2018)
    UCNS Board Certified in Behavioral Neurology/Neuropsychiatry
    Yale University School of Medicine (2017)
    Fellowship
    Yale University School of Medicine (2017)
    ABPN Board Certified in Adult Psychiatry
    SUNY Downstate Medical Center (2016)
    Residency
    SUNY Downstate Medical Center (2016)
    MD
    Ross School of Medicine (2009)
    MD
    Ross University School of Medicine West Indies (2007)
    BMath
    University of British Columbia, Mathematics

    Research

    Overview

    There is an alarming number of patients, including civilian populations, athletes, as well as veterans, suffering from the short and long term clinical sequelae of traumatic brain injury and co-morbid psychiatric disorders including Major Depressive Disorder and Post Traumatic Stress Disorder. Recent studies have shown that even one episode of traumatic brain injury could increase the likelihood of developing dementia, such as Alzheimer’s Disease. My prior research has involved studying potential mechanisms leading to chronic traumatic encephalopathy (CTE), which is proposed to involve tau accumulation in various regions of the brain including the sulci, as well as peri-vascular regions. I am currently focused on examining the long term sequelae of TBI. Finally, I will investigate the efficacy of potential therapeutic regimens, including medications that function via Fyn and mGluR5 pathways, which have been recognized to have key roles in both tau and amyloid based neurodegenerative processes, such as Alzheimer's Disease (AD). I am also actively involved with research involving behavioral variant frontotemporal dementia (bvFTD) and examining diagnostic approaches including synaptic alterations, using SV2A PET imaging.

    Medical Research Interests

    Neurodegenerative Diseases; Neurosciences

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Arman Fesharaki-Zadeh's published research.

    Publications

    2026

    2025

    2024

    Academic Achievements & Community Involvement

    Activities

    • activity

      National Neurotrauma Society

    • activity

      Frontiers in Cellular Neuroscience

    • activity

      NIC-FTD (Neuropsychiatric International Consortium-Frontotemporal Dementia)

    • activity

      International Society for Frontotemporal Dementia (ISFTD)

    Honors

    • honor

      PACC-TBI Award

    • honor

      Dementia and Neurodegenerative Diseases Editor’s Pick 2021 by Professor Bruce Miller

    • honor

      American Academy of Geriatric Psychiatry Honors Scholarship Award

    Clinical Care

    Overview

    Arman Fesharaki-Zadeh, MD, is a behavioral neurologist and neuropsychiatrist at Yale Medicine. He specializes in neurodegenerative diseases such as Alzheimer’s, Traumatic Brain Injury (TBI), and various types of dementia, such as Fronto-Temporal Dementia (FTD).

    Dr. Fesharaki-Zadeh grew up in Canada as the son of a surgeon. His father’s passion for medicine inspired him to go to medical school. He decided to focus on traumatic brain injury and other neurodegenerative diseases after his experiences as a psychiatry resident at a veteran’s hospital in Brooklyn. There, he noticed a subgroup of PTSD patients who did not respond to treatments even though they were on a maximum dose of medications. He discovered that many of these PTSD patients had also suffered from traumatic brain injuries, which complicated their conditions. In 2017, he completed a fellowship in behavioral neurology/ neuropsychiatry at Yale University School of Medicine.

    Currently, the majority of Dr. Fesharaki-Zadeh’s time is spent conducting research using animal models to understand traumatic brain injury and chronic traumatic encephalopathy.

    In addition to conducting research, Dr. Fesharaki-Zadeh also sees patients at Yale memory outpatient clinic . As a physician, his first priority is establishing trust with a patient. “A lot of the symptoms are personal, affecting their day-to-day lives, and for the patients to be able to trust their physician is of paramount importance,” he says.

    To establish that positive relationship, Dr. Fesharaki-Zadeh will start his appointments off with open-ended questions about what prompted them to see a physician, what has changed in their lives, and where they are in their life. He will also test patients’ short- and long-term memories in order to understand the severity of their conditions.

    In addition to seeing patients and conducting research, Dr. Fesharaki-Zadeh teaches psychiatry and neurology at Yale School of Medicine.

    Clinical Specialties

    Psychiatry; Neurology; Neuropsychiatry

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