Anfeng Luo

2026

• HOX code–based stratification reveals RUNX1T1–HDAC reprogramming as a targetable driver of lineage plasticity across cancers

  Jiang Y, Cheng S, Zhang CY, Jin X, Li L, Shin HE, Alrefai A, Luo A, Xu Y, Kim IY, Mu P. HOX code–based stratification reveals RUNX1T1–HDAC reprogramming as a targetable driver of lineage plasticity across cancers. Cancer Letters 2026, 648: 218465. DOI: 10.1016/j.canlet.2026.218465.

  Peer-Reviewed Original Research

  This study investigates how HOX gene expression patterns identify therapy-resistant cancer subtypes and demonstrates RUNX1T1-HDAC3 inhibition as a potential treatment strategy for aggressive cancers.

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