Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsAnderson M. Winkler, MD, DPhil
Assistant Clinical ProfessorAbout
Research
Publications
2025
Striatal compartment and white matter alterations in focal dystonia Subtypes: An MRI study
Marques Paulo A, Waugh J, Winkler A, Queiroz de Paiva J, de Faria D, Borges V, Silva S, de Ferraz H, Aguiar P. Striatal compartment and white matter alterations in focal dystonia Subtypes: An MRI study. Parkinsonism & Related Disorders 2025, 141: 108096. PMID: 41172714, DOI: 10.1016/j.parkreldis.2025.108096.Peer-Reviewed Original ResearchConceptsWhite matter alterationsHealthy controlsCervical dystoniaStriatal compartmentsUpper limb dystoniaCD patientsDystonia patientsStructural brain differencesDystonia subtypesAssociated with sensorimotorRight corona radiataT1-weighted imagesFocal dystonia patientsLeft caudateBrain differencesLimbic functionsLimb dystoniaSymptom severityLeft striatumNeuroanatomical patternsRight thalamusPutaminal volumeGlobus pallidusStriatumPathophysiological mechanismsReduced Threat-Related Neural Efficiency: A Possible Biomarker for Pediatric Anxiety Disorders.
Linke J, Naim R, Haller S, Khosravi P, Scheinberg B, Byrne M, Harrewijn A, Leibenluft E, Brotman M, Winkler A, Pine D. Reduced Threat-Related Neural Efficiency: A Possible Biomarker for Pediatric Anxiety Disorders. American Journal Of Psychiatry 2025, appiajp20241043. PMID: 41058235, PMCID: PMC12614269, DOI: 10.1176/appi.ajp.20241043.Peer-Reviewed Original ResearchCognitive-behavioral therapyPediatric anxiety disordersNeural efficiencyTest-retest reliabilityAnxiety disordersExposure-based CBTCBT responseCBT's efficacyAssociated with poor treatment responseDot-probe taskAnxiety disorder diagnosisTreatment responsePoor treatment responseAnxious youthThreat-relatedAdult psychopathologySymptom dimensionsPediatric anxietyAnxiety diagnosesThreat taskPsychiatric diagnosisDisorder diagnosisFunctional MRIFunctional connectivityHealthy youthIntegrating Multimodal Neuroimaging of Error Monitoring to Estimate Future Anxiety in Adolescents
Valadez E, Conte S, Richards J, Feng Y, Liuzzi L, McSweeney M, Tan E, Buzzell G, Morales S, Winkler A, Cardinale E, White L, Pine D, Fox N. Integrating Multimodal Neuroimaging of Error Monitoring to Estimate Future Anxiety in Adolescents. JAMA Network Open 2025, 8: e2539133. PMID: 41129147, PMCID: PMC12550640, DOI: 10.1001/jamanetworkopen.2025.39133.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMultimodal neuroimaging measuresError monitoringEarly temperamentCingulate activityAnxiety trajectoriesMultimodal neuroimagingFuture anxietyFunctional magnetic resonance imaging sessionDorsal anterior cingulate activityAnterior cingulate activityPosterior cingulate activityAnxiety change scoresIntegration of electroencephalogramFollow-up analysisFlanker taskAnxiety disordersClinical InterviewCommunity sampleBrain regionsEEG sessionsBrain activityNeuroimaging dataTemperamentAnxietyShared and distinct alterations in brain structure of youth with internalizing or externalizing disorders: Findings from the ENIGMA Antisocial Behavior, ADHD, MDD, and Anxiety Working Groups
Sophie Townend, Staginnus M, Gao Y, Alexander N, Arolt V, Banaschewski T, Beesdo-Baum K, Bellgrove M, Benegal V, Blair R, Blanco-Hinojo L, Boeken O, Böhnlein J, Bölte S, Bonnekoh L, Brandeis D, Bressan R, Breuer F, Bruin W, Buitelaar J, Burkhouse K, Calkins M, Cano M, Cardoner N, Chen H, Chen X, Coghill D, Colins O, Connolly C, Craig M, Cullen K, Dannlowski U, Davey C, Dietrich A, Dong D, Freitag C, Frodl T, Goossens L, Grotegerd D, Gur R, Gur R, Haavik J, Hagan C, Hahn T, Hamm A, Harrison B, Hartman C, Herrmann M, Ho T, Hoekstra P, Holla B, Ibrahim K, Jackowski A, Jamalabadi H, Jiang Y, Kircher T, Konrad K, Kraus A, Kuntsi J, Langhammer T, Lazaro L, Leehr E, Lueken U, Ma R, MacMaster F, Manfro G, Martinelli A, Meinert H, Meinert S, Michałowski J, Ming Q, Moeck R, Muehlhan M, Mujica-Parodi L, Mwangi B, Neufeld J, Nigg J, O'Gorman Tuura R, Oh H, Oosterlaan J, Paloyelis Y, Pan P, Passamonti L, Peñate W, Phan K, Plessen K, Pujol J, Remnélius K, Rivero F, Rubia K, Salas R, Salum G, Satterthwaite T, Schienle A, Schrammen E, Schruers K, Schumann G, Sethi A, Silk T, Skokauskas N, Smoller J, Soares J, Sørensen L, Stadler C, Stevens M, Straube B, Straube T, Ströhle A, Sudre G, Sukhodolsky D, Sully K, Sun X, Sylvester C, Toschi N, van der Werff S, Vance A, Vermeiren R, Wabnegger A, Wang X, Wendt J, Whittle S, Wiemer J, Winkler A, Wittchen H, Wu M, Wu Q, Yang T, Yang Y, Yao S, Zhang J, Zhou J, Zugman A, Zunta-Soares G, Zwanzger P, Thomopoulos S, Jahanshad N, Thompson P, Hilbert K, Baskin-Sommers A, Cecil C, Aghajani M, Pine D, van der Wee N, Stein D, Groenewold N, Bas-Hoogendam J, Han L, Pozzi E, Schmaal L, Franke B, Hoogman M, Walton E, De Brito S, Fairchild G. Shared and distinct alterations in brain structure of youth with internalizing or externalizing disorders: Findings from the ENIGMA Antisocial Behavior, ADHD, MDD, and Anxiety Working Groups. Biological Psychiatry 2025 PMID: 40812743, DOI: 10.1016/j.biopsych.2025.08.003.Peer-Reviewed Original ResearchExternalizing disordersBrain structuresAnxiety disordersDisorder-specific alterationsSubcortical brain alterationsMiddle temporal gyrusYouth psychiatric disordersFronto-parietal regionsRegional cortical thicknessT1-weighted MRI dataTransdiagnostic associationsSalience attributionEmotional processingTemporal gyrusSubcortical volumesAntisocial behaviorInternalizing disordersPsychiatric disordersBrain alterationsENIGMA consortiumGroup differencesIndividual disordersMega-AnalysisIntracranial volumeEntorhinal cortexLongitudinal changes in infant attention-related brain networks and fearful temperament
Filippi C, Massera A, Xing J, Park H, Valadez E, Elison J, Kanel D, Pine D, Fox N, Winkler A. Longitudinal changes in infant attention-related brain networks and fearful temperament. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 40684940, PMCID: PMC12340726, DOI: 10.1016/j.bpsc.2025.07.003.Peer-Reviewed Original ResearchResting-state functional connectivityDefault mode networkDorsal attentionFearful temperamentBrain networksResting-state functional connectivity changesAttention-related networksMarkers of anxietyFearful infantsAnxiety disordersMode networkAge-related changesAge-related decreaseFunctional connectivityNeonatal alterationsTemperamentAnxietyConnectome ProjectIndependent component analysisAged 2FearLongitudinal modelLongitudinal changesBaby Connectome ProjectFPNHuman development, inequality, and their associations with brain structure across 29 countries
Medel V, Alliende L, Bethlehem R, Seidlitz J, Ringlein G, Arango C, Arnatkevičiūtė A, Asmal L, Bellgrove M, Benegal V, Bernardo M, Billeke P, Bosch-Bayard J, Bressan R, Busatto G, Castro M, Chaim-Avancini T, Costanzi M, Czepielewski L, Dazzan P, de la Fuente-Sandoval C, Diaz-Caneja C, Di Forti M, Diaz-Zuluaga A, Du Plessis S, Duran F, Fittipaldi S, Fornito A, Freimer N, Gadelha A, Gama C, Garani R, Garcia-Rizo C, Campo C, Gonzalez-Valderrama A, Guinjoan S, Holla B, Ibañez A, Ivanovic D, Jackowski A, Leon-Ortiz P, Lochner C, Lopez-Jaramillo C, Luckhoff H, Massuda R, McGuire P, Miyata J, Mizrahi R, Murray R, Ozerdem A, Pan P, Parellada M, Phahladira L, Ramirez-Mahaluf J, Reckziegel R, Marques T, Reyes-Madrigal F, Roos A, Rosa P, Salum G, Scheffler F, Schumann G, Serpa M, Stein D, Tepper A, Tiego J, Ueno T, Undurraga J, Undurraga E, Valdes-Sosa P, Valli I, Villarreal M, Winton-Brown T, Yalin N, Zamorano F, Zanetti M, cVEDA, Winkler A, Evans-Lacko S, Crossley N. Human development, inequality, and their associations with brain structure across 29 countries. European Psychiatry 2025, 68: e100. PMID: 40665512, PMCID: PMC12344469, DOI: 10.1192/j.eurpsy.2025.10060.Peer-Reviewed Original ResearchConceptsBrain structuresAssociated with smaller hippocampal volumeGlobal cortical surface areaSmaller hippocampal volumeCortical surface areaMagnetic resonance imagingVariability of brain structureBrain-related disordersHealthy adultsThinner cortical thicknessCross-sectional studyHippocampal volumeFrontal areasMeta-regression approachBrain disordersCortical thicknessBrain imagingBrainHuman developmentDisordersLevel of developmentResonance imagingCountry levelAdultsCountry's level of developmentStructural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis
Bas-Hoogendam J, Bernstein R, Benson B, Frank S, Buss K, Gunther K, Pérez-Edgar K, Salum G, Jackowski A, Bressan R, Zugman A, Degnan K, Filippi C, Fox N, Henderson H, Tang A, Zeytinoglu S, Harrewijn A, Hillegers M, Muetzel R, White T, van IJzendoorn M, Schwartz C, Felicione J, DeYoung K, Shackman A, Smith J, Tillman R, van den Berg Y, Cillessen A, Roelofs K, Tyborowska A, Hill S, Battaglia M, Tettamanti M, Dougherty L, Jin J, Klein D, Leung H, Avery S, Blackford J, Clauss J, Bjork J, Hettema J, Moore A, Roberson-Nay R, Sawyers C, Hayden E, Liu P, Vandermeer M, Goldsmith H, Planalp E, Nichols T, Thompson P, Westenberg P, van der Wee N, Groenewold N, Stein D, Winkler A, Pine D. Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis. Journal Of The American Academy Of Child And Adolescent Psychiatry 2025 PMID: 40619094, PMCID: PMC12321241, DOI: 10.1016/j.jaac.2025.06.026.Peer-Reviewed Original ResearchStructural brain correlatesBrain structuresMega-AnalysisParietal regionsRight superior parietal regionCortical thicknessMagnetic resonance imagingStructural magnetic resonance imagingSuperior parietal regionsRegional brain structureWhole-brain approachMagnetic resonance imaging dataParent/teacher reportNeurobiological characteristicsPreregistered analysesNeural substratesSubcortical volumesMean cortical thicknessTemperament assessmentInternational research sitesLongitudinal designBrain functionSex interactionExploratory analysisTemperamentInfants’ Resting-State Functional Connectivity and Event-Related Potentials: A Multimodal Approach to Investigating the Neural Basis of Infant Novelty Detection
Kanel D, Morales S, Altman K, Richards J, Winkler A, Pine D, Fox N, Filippi C. Infants’ Resting-State Functional Connectivity and Event-Related Potentials: A Multimodal Approach to Investigating the Neural Basis of Infant Novelty Detection. Developmental Psychology 2025, 61: 1397-1411. PMID: 39760730, PMCID: PMC12416073, DOI: 10.1037/dev0001892.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingEvent-related potentialsEvent-related potential dataResting-state functional connectivityMismatch responsesFunctional connectivityRegions-of-interestRs-FCThree-stimulus auditory oddball taskResting-state functional magnetic resonance imagingFunctional magnetic resonance imaging dataSuperior parietal cortexPosterior cingulate cortexVentral attention networkSuperior parietal lobuleBilateral auditory corticesAuditory oddball taskNovelty detectionNovelty processingCingulate cortexNeural basisParietal lobuleNovel stimuliP3 responseSomatomotor networkBrain functional connectivity and anatomical features as predictors of cognitive behavioral therapy outcome for anxiety in youths
Zugman A, Ringlein G, Finn E, Lewis K, Berman E, Silverman W, Lebowitz E, Pine D, Winkler A. Brain functional connectivity and anatomical features as predictors of cognitive behavioral therapy outcome for anxiety in youths. Psychological Medicine 2025, 55: e91. PMID: 40125734, PMCID: PMC12080668, DOI: 10.1017/s0033291724003131.Peer-Reviewed Original ResearchConceptsCognitive-behavioral therapyConnectome predictive modelingWeeks of cognitive-behavioral therapyCognitive behavioural therapy outcomeResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingBehaviour therapy outcomePediatric anxiety disordersBaseline anxiety severityBrain functional connectivityAnxiety disordersAnxiety severityPediatric anxietyAnxiety diagnosesAnxiety symptomsFunctional connectivityTherapy outcomeAnxietyFirst-line treatmentTreatment responseTreatment outcomesMagnetic resonance imagingPredictive of responseFirst-lineClinical outcomesNeural Rewiring of Resilience: The Effects of Combat Deployment on Functional Network Architecture
Yair N, Zalmenson T, Azriel O, Shamai-Leshem D, Alon Y, Tik N, Tatsa-Laur L, Ben-Yehuda A, Pine D, Winkler A, Tavor I, Bar-Haim Y. Neural Rewiring of Resilience: The Effects of Combat Deployment on Functional Network Architecture. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 39824285, DOI: 10.1016/j.bpsc.2024.12.017.Peer-Reviewed Original ResearchFunctional magnetic resonance imaging studyBetween-network functional connectivityTrauma-related psychopathologyEffects of combat deploymentBetween-network connectivityVentral attention networkBrain functional architectureFunctional brain networksMagnetic resonance imaging studiesFunctional network architectureCognitive controlCombat exposureNeural basisBrain networksCombat deploymentFunctional connectivityResilient individualsGroup of university studentsResilient participantsAttention networkNeural adaptationSignificant groupComparison groupLongitudinal studyFunctional architecture