Amir Valizadeh
Associate Research ScientistDownloadHi-Res Photo
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Xu Lab
National Center for PTSD, Orange VA Clinic, 200 Edison Rd
Orange, CT 06477
United States
Publications Overview
- 13 Publications
- 179 Citations
- 9 Yale Co-Authors
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Associate Research Scientist
Biography
Amir Valizadeh earned his MD from Tehran University of Medical Sciences in 2019. His research integrates computational biology, machine learning, and clinical expertise, with a focus on multi-omics integration, epigenomic profiling, and biomarker discovery in psychiatry and immunology. Currently, as a Postdoctoral Associate at Yale School of Medicine and VA Connecticut Healthcare System, he is exploring transcriptomic alterations in SIV/HIV infection and leveraging AI for precision diagnostics, such as DNA methylation-based prediction of ketamine response in PTSD.
Last Updated on June 11, 2025.
Appointments
Psychiatry
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Associate
- Yale University (2025)
- Postdoctoral Research Fellow
- Tehran University Of Medical Sciences (2022)
- Research Assistant
- Research Center for Molecular and Cellular Imaging (2020)
- MD
- Tehran University Of Medical Sciences, Medicine (2019)
- Student Researcher
- Research Center for Immunodeficiencies (2018)
Research
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Overview
Medical Research Interests
Artificial Intelligence; Epigenomics; Neurosciences; Psychiatry
ORCID
0000-0001-5983-8527- View Lab Website
Xu Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Amir Valizadeh's published research.
Publications Timeline
A big-picture view of Amir Valizadeh's research output by year.
Ke Xu, MD
Chadi Abdallah, MD
Ismene Petrakis, MD
John Krystal, MD
Lynnette A. Averill, PhD
Matthew Girgenti, PhD
13Publications
179Citations
Publications
2026
Infections in patients with multiple sclerosis treated with disease-modifying therapies: A comparative risk assessment cohort study
Fattahi M, Valizadeh A, Azimi A, Moghadasi A, Ghasemi M, Navardi S, Doosti R, Hemmati Z, Zare-Dehnavi A, Iranmehr A, Hamtaei-Gashti S, Sahraian M. Infections in patients with multiple sclerosis treated with disease-modifying therapies: A comparative risk assessment cohort study. Iranian Journal Of Neurology 2026 DOI: 10.18502/cjn.v24i2.20684.Peer-Reviewed Original ResearchConceptsDisease-modifying therapiesUrinary tract infectionMultiple sclerosisHigher risk of urinary tract infectionAltered riskCohort studyRisk of urinary tract infectionHigh riskRetrospective cohort studyRisk of complicationsYears of ageInfectious complicationsRisk of infectionBacterial vaginitisTract infectionsGlatiramer acetateTreatment regimensMcDonald criteriaComplicationsRisk factorsBacterial infectionsPatientsExclusion criteriaDimethyl fumarateInfection
2025
Combining DNA methylation features and clinical characteristics predicts ketamine treatment response for PTSD
Valizadeh A, Roache J, Zhang X, Hu Y, Gueorguieva R, Averill L, Ranganathan M, Wang Z, Williamson D, Shiroma P, Girgenti M, Petrakis I, López-Roca A, Young-McCaughan S, Keane T, Peterson A, Abdallah C, Krystal J, Xu K, PTSD F. Combining DNA methylation features and clinical characteristics predicts ketamine treatment response for PTSD. IScience 2025, 29: 114445. PMID: 41561376, PMCID: PMC12814687, DOI: 10.1016/j.isci.2025.114445.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPost-traumatic stress disorderDNA methylation patternsDNA methylation featuresDNA methylation profilesStudies of ketamineBlood DNA methylation profilesBenefits of ketamineTreatment responseNear genesRisk lociMethylation sitesMethylation patternsMethylation featuresStress disorderMethylation profilesGlutamatergic signalingResponse subgroupsKetamineClinical measuresClinical variablesRandomized studyImmune regulationBiological variablesLociCpGsTranscriptomic Alterations Induced by Tetrahydrocannabinol in SIV/HIV Infection: A Systematic Review
Valizadeh A, Veenhuis R, Bradley B, Xu K. Transcriptomic Alterations Induced by Tetrahydrocannabinol in SIV/HIV Infection: A Systematic Review. International Journal Of Molecular Sciences 2025, 26: 2598. PMID: 40141240, PMCID: PMC11942185, DOI: 10.3390/ijms26062598.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsSimian immunodeficiency virus (SIV)-infected macaquesPrevalence of cannabis useSIV-infected macaquesChronic immune activationHIV-infected human cellsEpithelial cell proliferationModulate immune responsesSystematic reviewSIV/HIV infectionHIV infectionPreclinical evidencePathways related to inflammationImmune activationCannabis useMicro-RNA expressionImmunomodulatory roleImmunomodulatory effectsReduce inflammationImmune responseTetrahydrocannabinolComprehensive searchCell proliferationTranscriptomic alterationsMethodological qualityPWHAberrant DNA methylation of genes regulating CD4+ T cell HIV‐1 reservoir in women with HIV
Xu K, Zhang X, Asam K, Quach B, Page G, Konkle‐Parker D, Martinez C, Lahiri C, Topper E, Cohen M, Kassaye S, DeHovitz J, Kuniholm M, Archin N, Valizadeh A, Tien P, Marconi V, Hancock D, Johnson E, Aouizerat B. Aberrant DNA methylation of genes regulating CD4+ T cell HIV‐1 reservoir in women with HIV. Clinical And Translational Medicine 2025, 15: e70267. PMID: 40070009, PMCID: PMC11896887, DOI: 10.1002/ctm2.70267.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCD4+ T cellsHIV-1 reservoirHIV-1 latencyT cellsHIV-1Aberrant DNA methylationMechanisms of HIV-1 latencyViral replicationVirally suppressed womenDNA methylationHIV-1 integration sitesHIV-1 replicationMolecular targetsDifferentially methylated CpG sitesImmune defenceDNA methylation sequencingHost epigenetic landscapeDNA methylation sitesHIV-1 DNA integrationDifferentially methylated sitesHost genome integrityInterferon signaling genesCure HIVHost-virus interactionsCD4
2023
Automated diagnosis of autism with artificial intelligence: State of the art
Valizadeh A, Moassefi M, Nakhostin-Ansari A, Some’eh S, Hosseini-Asl H, Torbati M, Aghajani R, Ghorbani Z, Menbari-Oskouie I, Aghajani F, Mirzamohamadi A, Ghafouri M, Faghani S, Memari A. Automated diagnosis of autism with artificial intelligence: State of the art. Reviews In The Neurosciences 2023, 35: 141-163. PMID: 37678819, DOI: 10.1515/revneuro-2023-0050.Peer-Reviewed Original ResearchCitations
2022
The mirror mechanism in schizophrenia: A systematic review and qualitative meta-analysis
Valizadeh A, Mbwogge M, Yazdi A, Amlashi N, Haadi A, Shayestefar M, Moassefi M. The mirror mechanism in schizophrenia: A systematic review and qualitative meta-analysis. Frontiers In Psychiatry 2022, 13: 884828. PMID: 36213922, PMCID: PMC9532849, DOI: 10.3389/fpsyt.2022.884828.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMirror neuron activityCortical motor systemSchizophrenia patientsMirror neuron systemUnderlying pathophysiologyCertainty of evidenceCase-control studyNew rehabilitation methodWeb of ScienceObjective assessment toolEligible studiesHealthy controlsVisuomotor neuronsPatientsNeuron activityPositive symptomsSystematic reviewInvestigation of heterogeneityMicrostructural integrityVote counting methodNeuron systemPathophysiologySymptomsFunctional integrityRehabilitation methodsThe safety and efficacy of umbilical cord blood mononuclear cells in individuals with spastic cerebral palsy: a randomized double-blind sham-controlled clinical trial
Zarrabi M, Akbari M, Amanat M, Majmaa A, Moaiedi A, Montazerlotfelahi H, Nouri M, Hamidieh A, Badv R, Karimi H, Rabbani A, Mohebbi A, Rahimi-Dehgolan S, Rahimi R, Dehghan E, Vosough M, Abroun S, Shamsabadi F, Tavasoli A, Alizadeh H, Pak N, Zamani G, Mohammadi M, Javadzadeh M, Ghofrani M, Hassanpour S, Heidari M, Taghdiri M, Mohseni M, Noparast Z, Masoomi S, Goudarzi M, Mohamadpour M, Shodjaee R, Samimi S, Mohammad M, Gholami M, Vafaei N, Koochakzadeh L, Valizadeh A, Malamiri R, Ashrafi M. The safety and efficacy of umbilical cord blood mononuclear cells in individuals with spastic cerebral palsy: a randomized double-blind sham-controlled clinical trial. BMC Neurology 2022, 22: 123. PMID: 35351020, PMCID: PMC8966246, DOI: 10.1186/s12883-022-02636-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsUmbilical cord blood mononuclear cellsCord blood mononuclear cellsSpastic cerebral palsyBlood mononuclear cellsCerebral palsyHuman leukocyte antigenPosterior thalamic radiationUCB-MNCAdverse eventsFractional anisotropyMononuclear cellsCorticospinal tractWhite matter structuresMean changeDouble-blind sham-controlled clinical trialControl groupMean GMFM-66 scoresGross Motor Function MeasureSham-controlled clinical trialExperimental groupCommon adverse eventsDouble-blind studyMotor Function MeasureGMFM-66 scoresTrial registrationThe studyDisease‐modifying therapies and T1 hypointense lesions in patients with multiple sclerosis: A systematic review and meta‐analysis
Valizadeh A, Fattahi M, Sadeghi M, Torbati M, Sahraian M, Azimi A. Disease‐modifying therapies and T1 hypointense lesions in patients with multiple sclerosis: A systematic review and meta‐analysis. CNS Neuroscience & Therapeutics 2022, 28: 648-657. PMID: 35218155, PMCID: PMC8981477, DOI: 10.1111/cns.13815.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDisease-modifying therapiesCertainty of evidenceVolumes of T1Hypointense lesionsMultiple sclerosis patientsRisk of biasRoB 2 toolT1-hypointense lesionsRandom-effects modelEffects of FDANumber of lesionsAdult patientsSclerosis patientsMultiple sclerosisComparator groupPrognostic markerObjective markersSystematic reviewLesionsMean differenceMean volumePatientsRelevant studiesHypointenseTherapy
2021
Correlation between the clinical disability and T1 hypointense lesions’ volume in cerebral magnetic resonance imaging of multiple sclerosis patients: A systematic review and meta‐analysis
Valizadeh A, Moassefi M, Barati E, Sahraian M, Aghajani F, Fattahi M. Correlation between the clinical disability and T1 hypointense lesions’ volume in cerebral magnetic resonance imaging of multiple sclerosis patients: A systematic review and meta‐analysis. CNS Neuroscience & Therapeutics 2021, 27: 1268-1280. PMID: 34605190, PMCID: PMC8504532, DOI: 10.1111/cns.13734.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMean volumeCerebral magnetic resonance imagingPrognosis Studies toolMultiple sclerosis patientsRisk of biasT1-hypointense lesionsRandom-effects modelMagnetic resonance imagingWeb of ScienceClinical disabilityAdult patientsCerebral MRIEDSS scoreSclerosis patientsMultiple sclerosisDisability levelHypointense lesionsSystematic reviewResonance imagingPatientsRelevant studiesStudy toolCorrelation coefficientT1EDSSA placebo-controlled randomized clinical trial of amantadine hydrochloride for evaluating the functional improvement of patients following severe acute traumatic brain injury.
Shimia M, Iranmehr A, Valizadeh A, Mirzaei F, Namvar M, Rafiei E, Rahimi A, Khadivi A, Aeinfar K. A placebo-controlled randomized clinical trial of amantadine hydrochloride for evaluating the functional improvement of patients following severe acute traumatic brain injury. Journal Of Neurosurgical Sciences 2021, 67: 598-604. PMID: 34114429, DOI: 10.23736/s0390-5616.21.05266-8.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsGlasgow Outcome ScaleDisability Rating ScaleTraumatic brain injurySevere TBI patientsAmantadine hydrochlorideTBI patientsBrain injuryFunctional improvementClinical trialsSevere acute traumatic brain injuryAcute traumatic brain injuryMean Glasgow Outcome ScaleSevere traumatic brain injuryFunctional ability improvementEffect of amantadineDopaminergic neurotransmitter systemWeeks of trialAmantadine groupPharmacologic optionsDopamine agonistsOutcome ScaleNeurotransmitter systemsOutcome measurementsPatientsRating Scale
Academic Achievements & Community Involvement
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activity Student Headquarters Against COVID-19 at Tehran University of Medical Sciences
2020 - 2020Public ServiceVice Presidentactivity Internship Committee at Tehran University of Medical Sciences
2019 - 2020CommitteesChair
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Xu Lab
National Center for PTSD, Orange VA Clinic, 200 Edison Rd
Orange, CT 06477
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New Haven, CT 06510
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