Alexander B. Pine, MD, PhD
Assistant Professor of Medicine (Hematology)DownloadHi-Res Photo
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Assistant Professor of Medicine, Hematology
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View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
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Assistant Professor of Medicine, Hematology
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Assistant Professor of Medicine, Hematology
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About
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Titles
Assistant Professor of Medicine (Hematology)
Assistant Professor of Medicine, Hematology
Biography
Last Updated on November 02, 2023.
Appointments
Medical Oncology and Hematology
Assistant ProfessorPrimary
Other Departments & Organizations
- Creed House Affiliates
- Hematology
- Internal Medicine
- Medical Oncology and Hematology
- Yale Cancer Center
- Yale Medicine
Education & Training
- Clinical Fellow (Hematology/Oncology)
- Yale School of Medicine (2020)
- Residency
- Yale New Haven Hospital (2015)
- Internship
- Yale New Haven Hospital (2013)
- MD
- Case Western Reserve University School of Medicine (2012)
- PhD
- Drexel University (2002)
Research
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Overview
Medical Research Interests
Antiphospholipid Syndrome; Blood Coagulation Disorders; Hematology
ORCID
0000-0002-9463-3022
Research at a Glance
Yale Co-Authors
Frequent collaborators of Alexander B. Pine's published research.
Publications Timeline
A big-picture view of Alexander B. Pine's research output by year.
Research Interests
Research topics Alexander B. Pine is interested in exploring.
Alfred Lee, MD, PhD
Amer Zeidan, MBBS
Ayesha Butt, MBBS
George Goshua, MD, MSc, FACP
Hanming Zhang, PhD
Noffar Bar, MD
35Publications
2,135Citations
Blood Coagulation Disorders
Publications
2024
Cancer-Associated Venous Thromboembolic Disease, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology.
Streiff M, Holmstrom B, Angelini D, Ashrani A, Buckner T, Diep R, Fertrin K, Fogerty A, Crestani N, Gangaraju R, Rojas-Hernandez C, Goldhaber S, Ibrahim I, Kubal T, Leavitt A, Lim M, Mann J, Mantha S, Morton C, Nester A, O'Brien A, Ortel T, Pine A, Pishko A, Ranade M, Salmasi A, Schaefer J, Williams E, Wool G, Wun T, Montgomery S, Nguyen J, Freedman-Cass D, Sliker B. Cancer-Associated Venous Thromboembolic Disease, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network 2024, 22: 483-506. PMID: 39236759, DOI: 10.6004/jnccn.2024.0046.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNCCN Clinical Practice GuidelinesNCCN guidelinesClinical practice guidelinesVenous thromboembolismVenous thromboembolic diseaseNCCN panelCancer-associated venous thromboembolismInternal medicinePractice guidelinesMedical oncologyThromboembolic diseaseTreatment of venous thromboembolismNCCNLife-threatening conditionMultidisciplinary effortRecommended treatment optionGuidelinesOncologyAdult patientsTreatment optionsInterventional radiologyDiverse subtypesCancerPatientsPreventionFactor VIII Levels and ISTH Disseminated Intravascular Coagulation Scores Do Not Distinguish Disseminated Intravascular Coagulation from the Coagulopathy of Liver Disease
Allen C, Heskel M, Butt A, Tormey C, Pine A, Lee A, Gautam S. Factor VIII Levels and ISTH Disseminated Intravascular Coagulation Scores Do Not Distinguish Disseminated Intravascular Coagulation from the Coagulopathy of Liver Disease. Acta Haematologica 2024, 148: 220-225. PMID: 39004080, PMCID: PMC12106121, DOI: 10.1159/000540239.Peer-Reviewed Original ResearchConceptsISTH DIC scoreFactor VIII levelsArea under the curveDIC scoreLiver diseaseFactor VIIIRetrospective chart review of patientsChart review of patientsCoagulopathy of liver diseaseReview of patientsRetrospective chart reviewCalculate area under the curveReceiver operating characteristic curveMultiple logistic regressionISTH scoreLaboratory parametersClinical challengeClinical utilityPatientsCharacteristic curveLab variablesLogistic regressionLiverDiseaseDiagnostic tool
2023
Proteomic Profiling of Different Antiphospholipid Antibody-Positive Phenotypes: Results from Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Registry
Pine A, Butt A, Garcia-Milian R, Gu S, Restrepo V, Chock Y, Hwa J, Tormey C, Rinder H, Goshua G, Belmont H, Bertolaccini M, Branch D, Erhan D, Kello N, Knight J, Petri M, Willis R, Lee A, Sharda A. Proteomic Profiling of Different Antiphospholipid Antibody-Positive Phenotypes: Results from Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Registry. Blood 2023, 142: 2575. DOI: 10.1182/blood-2023-185232.Peer-Reviewed Original ResearchCitationsConceptsNeutrophil extracellular trapsAntiphospholipid syndromeHumoral immune responseImmune responseClinical phenotypePathophysiology of APSPathogenesis of APSSapporo classification criteriaAPL-positive patientsPathway enrichment analysisEffector cell differentiationAntiPhospholipid Syndrome AllianceDifferent clinical phenotypesProteomic profilingPlasma proteomic profilingPatient plasma samplesAPL antibodiesAPS pathogenesisAntiphospholipid antibodiesObstetric complicationsPositive aPLCytokine stormMedian ageMicrovascular disordersConcurrent diagnosisComprehensive Characterization of Coagulation Parameters in Venous Malformations
Restrepo V, Pine A, Butt A, Chang E, Bar N, Baluha A, Brooks A, Chirico G, Curran J, Dumont A, Obura-Wilkes P, Rinder H, Tormey C, Nassiri N, Lee A, Prozora S. Comprehensive Characterization of Coagulation Parameters in Venous Malformations. Blood 2023, 142: 27. DOI: 10.1182/blood-2023-190609.Peer-Reviewed Original ResearchConceptsHigher thrombin-antithrombin complexesNormal D-dimerThrombin-antithrombin complexPlasminogen activator inhibitor-1Localized intravascular coagulopathyInternational normalized ratioD-dimerVenous malformationsCoagulation parametersPartial thromboplastin timeCoagulation testsFactor VIIIVWF activityChart reviewMost patientsHematology clinicProthrombin timeTissue involvementVWF antigenVon Willebrand factor antigenHigher TAT levelsMultiple coagulation parametersBaseline patient characteristicsRetrospective chart reviewCoagulation test resultsCAR T-Related Toxicities Based on Dynamic Proteomic Profiles Identifies Risk Factors for Cytokine Release Syndrome (CRS) and Immune Effector Cell -Associated Neurotoxicity Syndrome (ICANS)
Kewan T, Mirza S, Pine A, Rasheed Y, Hamouche R, Leveille E, Goshua G, Gu S, Liu Y, Vanoudenhove J, Bar N, Neparidze N, Foss F, Gowda L, Isufi I, Halene S, Lee A, Seropian S. CAR T-Related Toxicities Based on Dynamic Proteomic Profiles Identifies Risk Factors for Cytokine Release Syndrome (CRS) and Immune Effector Cell -Associated Neurotoxicity Syndrome (ICANS). Blood 2023, 142: 2132. DOI: 10.1182/blood-2023-187295.Peer-Reviewed Original ResearchCitationsConceptsCytokine release syndromeDiffuse large B-cell lymphomaCAR T-cell therapyCAR T-cell productsCAR-T productsNon-Hodgkin lymphomaBest cutoff pointMultiple myelomaHigher oddsDay 3Risk factorsTime pointsCutoff pointDay 5Day 0Median absolute lymphocyte countChimeric antigen receptor T cellsRefractory non-Hodgkin lymphomaCAR T-cell infusionAntigen receptor T cellsLarge B-cell lymphomaCAR-T activationFludarabine/cyclophosphamideHigher baseline CRPPossible inflammatory mediatorsThe Choice of Anticoagulant at First Recurrence Does Not Alter the Risk for the Second Recurrence
Muradashvili T, Restrepo V, Alameddine D, Soliman S, Feinn R, Chaar C, Lee A, Pine A. The Choice of Anticoagulant at First Recurrence Does Not Alter the Risk for the Second Recurrence. Blood 2023, 142: 5540. DOI: 10.1182/blood-2023-191084.Peer-Reviewed Original ResearchConceptsFirst VTE recurrenceDeep venous thrombosisFirst venous thromboembolismRecurrent VTE eventsVTE recurrenceVenous thromboembolismPulmonary embolismAnticoagulation regimenVTE eventsAnticoagulant regimenFirst recurrenceINR targetSecond recurrenceExact testFirst recurrent venous thromboembolismInferior vena cava atresiaLarge tertiary academic hospitalUnprovoked first venous thromboembolismMajor public health hazardDifferent anticoagulant agentsInterruption of anticoagulationCardiovascular risk factorsMay-Thurner syndromePatients 18 yearsRecurrent venous thromboembolismA New Model for Diagnosing Sepsis-induced Disseminated Intravascular Coagulation (DIC) in Patients With Coagulopathy of Liver Disease--Moving Away From Factor VIII (FVIII) and International Society on Thrombosis and Hemostasis (ISTH) DIC Scores
Allen C, Heskel M, Butt A, Pine A, Lee A, Gautam S. A New Model for Diagnosing Sepsis-induced Disseminated Intravascular Coagulation (DIC) in Patients With Coagulopathy of Liver Disease--Moving Away From Factor VIII (FVIII) and International Society on Thrombosis and Hemostasis (ISTH) DIC Scores. 2023, a6391-a6391. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6391.Peer-Reviewed Original ResearchImpact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome
Allen C, Gautam S, Cheng W, Pine A, Podoltsev N, Zeidan A, Lee A, Shallis R. Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome. Acta Haematologica 2023, 146: 287-292. PMID: 37166332, PMCID: PMC12106122, DOI: 10.1159/000530153.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsAML/myelodysplastic syndromeAcute myeloid leukemiaInternational normalized ratioAntibacterial prophylaxisMyelodysplastic syndromeProphylactic antibacterialsCoagulation profileAcute myeloid leukemia/myelodysplastic syndromeDiagnosis of AMLHigher international normalized ratioLeukemia/myelodysplastic syndromePartial thromboplastin time prolongationYale-New Haven HospitalYale-New HavenRetrospective cohort studyAbnormal coagulation profileGroup of patientsTime of admissionHigh rateIndividual patient encountersInstitutional review boardAntibacterial exposureRelevant bleedingAdult patientsCohort study
2022
Plasma Proteomic Profiling Illustrates Endothelial and Complement Signature in Patients with Alcohol-Associated Cirrhosis
Allen C, Butt A, Zhao X, Li F, Bahel P, Chang C, Chun H, Gu S, Hwa J, Jakab S, Chen B, Garcia-Tsao G, Rinder H, To U, McConnell M, Lee A, Pine A. Plasma Proteomic Profiling Illustrates Endothelial and Complement Signature in Patients with Alcohol-Associated Cirrhosis. Blood 2022, 140: 8382-8383. DOI: 10.1182/blood-2022-162633.Peer-Reviewed Original ResearchProteomic Profiles of Cytokine Release Syndromes Following Lisocabtagene Maraleucel and Idecabtagene Vicleucel
Mirza A, Pine A, Rasheed Y, Hamouche R, Leveille E, Goshua G, Gu S, Liu Y, VanOudenhove J, Bar N, Neparidze N, Foss F, Gowda L, Isufi I, Halene S, Lee A, Seropian S. Proteomic Profiles of Cytokine Release Syndromes Following Lisocabtagene Maraleucel and Idecabtagene Vicleucel. Blood 2022, 140: 10410-10412. DOI: 10.1182/blood-2022-168374.Peer-Reviewed Original ResearchCitationsConcepts
Academic Achievements & Community Involvement
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Activities
activity American Society of Hematology
2017 - PresentProfessional OrganizationsMemberactivity National Comprehensive Cancer Network
2022 - PresentProfessional OrganizationsCommittee MemberDetailsDr. Pine is a member of NCCN Guidelines for Cancer-Associated Venous Thromboembolic Disease Panelactivity Proteomics of Antiphospholipid Syndromes
11/17/2023 - 11/17/2023Oral PresentationAntiphospholipid syndrome Alliance for Clinical Trials and International Networking (APS ACTION) 14th Annual Virtual SummitDetailsHeld virtuallyactivity Plasma Proteomic Profiling in Antiphospholipid Antibody-positive Patients with Different Clinical Phenotypes: Results from the Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Registry
11/13/2023 - 11/13/2023Oral Presentation American College of RheumatologyDetailsSan Diego, CA, United StatesCollaboratorsactivity COVID-19 and Antiphospholipid Syndrome
05/10/2023 - 05/10/2023LectureYale Rheumatology Grand RoundsDetailsNew Haven, CT, United States
Honors
honor Hematology and Medical Oncology Fellowship Program Annual Research Award
06/30/2020Yale School of Medicine AwardYale Cancer CenterDetailsUnited States
Teaching & Mentoring
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Mentoring
Valentina Restrepo-Espinosa, MD
Postdoc2023 - PresentTariq Kewan
hematology oncology fellow2023 - PresentCecily Allen, MD
Internal medical resident2021 - 2023Daria Madeeva
Internal medicine resident2020 - 2022
Clinical Care
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Overview
Alexander B. Pine, MD, PhD, is a hematologist specializing in blood clotting disorders and antiphospholipid syndrome, an autoimmune disorder where the body produces antibodies that make the blood more likely to clot, leading to an increased risk of blood clots, miscarriages, and other complications. He provides comprehensive care to patients with these conditions, using various approaches to manage and treat blood-related health issues.
As an assistant professor of medicine at Yale School of Medicine, Dr. Pine is involved in research focused on understanding blood coagulation disorders and their impact on health. He completed his medical training at Case Western Reserve University School of Medicine, followed by an internship and residency at Yale New Haven Hospital. Dr. Pine further specialized with a clinical fellowship in hematology and oncology at Yale School of Medicine.
Clinical Specialties
Internal Medicine; Hematology
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