Abedalrazaq Alkukhun, MBBS, MD, MPH
Assistant Professor of Radiology and Biomedical ImagingAbout
Research
Publications
2025
Accuracy of Computed Tomography Staging of Mismatch Repair-Deficient Colon Cancer.
Linhares S, Srikumar T, Shin C, Mathur M, Alkukhun A, Mongiu A, Leeds I, Reddy V, Pantel H, Cecchini M. Accuracy of Computed Tomography Staging of Mismatch Repair-Deficient Colon Cancer. JCO Oncology Practice 2025, op2500505. PMID: 41252662, DOI: 10.1200/op-25-00505.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsAccuracy of clinical stagingNeoadjuvant immune checkpoint inhibitorsClinical stageComputed tomographyColon cancerNodal stagingT stagePathological stageDMMR tumorsModerate to substantial IRRCohort studyClinically staged patientsSystemic therapy decisionsLocally advanced diseaseUpfront surgical resectionLow-risk tumorsLymph node statusMismatch repair-proficientOverstaging rateUnderstaging rateCheckpoint inhibitorsNeoadjuvant treatmentNodal statusPreoperative CT
2024
Artificial Intelligence–Driven Patient Selection for Preoperative Portal Vein Embolization for Patients with Colorectal Cancer Liver Metastases
Kuhn T, Engelhardt W, Kahl V, Alkukhun A, Gross M, Iseke S, Onofrey J, Covey A, Camacho J, Kawaguchi Y, Hasegawa K, Odisio B, Vauthey J, Antoch G, Chapiro J, Madoff D. Artificial Intelligence–Driven Patient Selection for Preoperative Portal Vein Embolization for Patients with Colorectal Cancer Liver Metastases. Journal Of Vascular And Interventional Radiology 2024, 36: 477-488. PMID: 39638087, DOI: 10.1016/j.jvir.2024.11.025.Peer-Reviewed Original ResearchTotal liver volumeMetastatic colorectal cancer patientsPreoperative portal vein embolizationColorectal cancer liver metastasesPortal vein embolizationCancer liver metastasesMulticenter retrospective studyColorectal cancer patientsStudent's t-testBoard-certified radiologistsVein embolizationConsecutive patientsLiver metastasesLiver volumePatient selectionRetrospective studyCancer patientsRadiomic featuresInclusion criteriaPatientsSemi-automatic segmentationLab valuesT-testSDAUC
2023
Deferral of Estimated Glomerular Filtration Rate Testing Before Contrast-Enhanced CT in Low-Risk Emergency Department Patients: Assessment of Safety and Impact on Throughput
Gunabushanam G, Asch D, van Luling J, Kuehne A, Alkukhun A, Staib L, Venkatesh A, Pahade J. Deferral of Estimated Glomerular Filtration Rate Testing Before Contrast-Enhanced CT in Low-Risk Emergency Department Patients: Assessment of Safety and Impact on Throughput. Journal Of The American College Of Radiology 2023, 21: 52-60. PMID: 37939813, DOI: 10.1016/j.jacr.2023.11.003.Peer-Reviewed Original ResearchAcute kidney injuryChronic kidney diseaseContrast-enhanced CTLower riskED providersMedian OSEGFR testingContrast-induced acute kidney injuryLow-risk emergency department patientsLow-risk ED patientsProportion of patientsEmergency department patientsClinical risk assessmentGlomerular filtration rate testingAssessment of safetyChronic dialysisKidney injuryDepartment patientsED patientsEGFR valuesKidney diseaseRisk factorsPatientsCECT studiesRisk
2021
Variants of the aortic arch in adult general population and their association with thoracic aortic aneurysm disease
Yousef S, Singh S, Alkukhun A, Alturkmani B, Mori M, Chen J, Mullan CW, Brooks CW, Assi R, Gruber PJ, Cortopassi I, Geirsson A, Vallabhajosyula P. Variants of the aortic arch in adult general population and their association with thoracic aortic aneurysm disease. Journal Of Cardiac Surgery 2021, 36: 2348-2354. PMID: 33855754, DOI: 10.1111/jocs.15563.Peer-Reviewed Original ResearchConceptsAortic arch anomaliesArch anomaliesAneurysm diseaseBovine archAberrant right subclavian arteryAdult populationThoracic aortic aneurysm diseasePrevalence of TAAsRight-sided archRight subclavian arteryCharacteristics of patientsIndependent risk factorAortic valve pathologyAdult general populationGeneral adult populationAortic aneurysm diseaseLogistic regression analysisSingle health systemFisher's exact testOlder adult populationBinary logistic regressionThoracic aortopathiesSubclavian arteryCommon diagnosisThoracic aneurysm
2020
Mesenteric Amyloidosis: Radiologic Imaging with Pathologic Correlation
Alkukhun A, Rezek I, Ghiassi S, Zhang X, Revzin MV. Mesenteric Amyloidosis: Radiologic Imaging with Pathologic Correlation. Journal Of Clinical Imaging Science 2020, 10: 24. PMID: 32363086, PMCID: PMC7193195, DOI: 10.25259/jcis_10_2020.Peer-Reviewed Original Research
2017
Chapter 2 Molecular Aspects of the Calcium-Sensing Receptor and Calcium Homeostasis
Alkukhun A, Munoz-Abraham A, Judeeba S, Geibel J. Chapter 2 Molecular Aspects of the Calcium-Sensing Receptor and Calcium Homeostasis. 2017, 15-26. DOI: 10.1016/b978-0-12-802168-2.00002-6.ChaptersCalcium homeostasisImmune barrier functionCalcium sensing receptorGastric acid secretionCalcium-sensing receptorExtracellular calcium levelsVitamin DAntidiarrheal effectBile flowHormone secretionParathyroid glandsImmune responseGastrointestinal tractAcid secretionIntestinal floraElectrolyte balanceCalcium levelsBone mineralizationBarrier functionCaSROsteoclast proliferationKey modulatorReceptorsSecretionPhysiological functions
2016
Use of Fluorescein Isothiocyanate-Inulin as a Marker for Intestinal Ischemic Injury
AlKukhun A, Caturegli G, Munoz-Abraham AS, Judeeba S, Patron-Lozano R, Morotti R, Rodriguez-Davalos MI, Geibel JP. Use of Fluorescein Isothiocyanate-Inulin as a Marker for Intestinal Ischemic Injury. Journal Of The American College Of Surgeons 2016, 224: 1066-1073. PMID: 28017811, DOI: 10.1016/j.jamcollsurg.2016.12.016.Peer-Reviewed Original ResearchConceptsFluorescein isothiocyanate-inulinIschemic injuryIntestinal ischemiaIntestinal transplantationFluid secretionIntestinal ischemic injuryIntestinal tissue samplesSmall intestine segmentsHEPES-Ringer solutionIntestinal graftMesenteric ischemiaIschemic intestineHistopathologic samplesExperimental armControl armControl intestineIschemic stateBlinded pathologistIschemiaIntestinal lumenIntestinal tissueIntestine segmentsScoring systemFluid shiftsInjuryIs Normothermic Perfusion a Feasible Option for Intestinal Preservation? Experience with a Porcine Model
Bertacco A, AlKukhun A, Kitay A, Aldajani M, D'Amico F, Rodriguez-Davalos M, Mulligan D, Geibel J. Is Normothermic Perfusion a Feasible Option for Intestinal Preservation? Experience with a Porcine Model. Journal Of The American College Of Surgeons 2016, 223: e50-e51. DOI: 10.1016/j.jamcollsurg.2016.08.147.Peer-Reviewed Original ResearchUse of FITC-Inulin As a Real-Time Marker For Intestinal Graft Viability
AlKukhun A, Bertacco A, Abraham A, Caturegli G, D'Amico F, Rodriguez-Davalos M, Mulligan D, Geibel J. Use of FITC-Inulin As a Real-Time Marker For Intestinal Graft Viability. Journal Of The American College Of Surgeons 2016, 223: e193. DOI: 10.1016/j.jamcollsurg.2016.08.489.Peer-Reviewed Original Research
2012
An international basic science and clinical research summer program for medical students
Ramjiawan B, Pierce G, Anindo M, AlKukhun A, Alshammari A, Chamsi A, Abousaleh M, Alkhani A, Ganguly P. An international basic science and clinical research summer program for medical students. Advances In Physiology Education 2012, 36: 27-33. PMID: 22383409, DOI: 10.1152/advan.00056.2011.Peer-Reviewed Original Research