Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsBruce Haffty, MD
About
Research
Publications
2025
ASO Author Reflections: Preoperative Radiation Boost Reduces Re-Excision Rate and Locoregional Treatment Time in Early-Stage Breast Cancer Patients
Chakraborty M, Haffty B. ASO Author Reflections: Preoperative Radiation Boost Reduces Re-Excision Rate and Locoregional Treatment Time in Early-Stage Breast Cancer Patients. Annals Of Surgical Oncology 2025, 1-2. PMID: 40897941, DOI: 10.1245/s10434-025-18271-z.Peer-Reviewed Original ResearchASO Visual Abstract: Preoperative Radiation Boosts Results in Low Rates of Re-Excision and Reduced Locoregional Treatment Time for Breast Cancer Patients
Chakraborty M, Sherwani Z, Narra L, Abou Yehia Z, Ohri N, Cui T, Eladoumikdachi F, Kowzun M, Kumar S, Potdevin L, Toppmeyer D, Haffty B. ASO Visual Abstract: Preoperative Radiation Boosts Results in Low Rates of Re-Excision and Reduced Locoregional Treatment Time for Breast Cancer Patients. Annals Of Surgical Oncology 2025, 1-2. DOI: 10.1245/s10434-025-18245-1.Peer-Reviewed Original ResearchPreoperative Radiation Boost Results in Low Rates of Re-excision and Reduced Locoregional Treatment Time in Breast Cancer Patients
Chakraborty M, Sherwani Z, Narra L, Abou Yehia Z, Ohri N, Cui T, Eladoumikdachi F, Kowzun M, Kumar S, Potdevin L, Toppmeyer D, Haffty B. Preoperative Radiation Boost Results in Low Rates of Re-excision and Reduced Locoregional Treatment Time in Breast Cancer Patients. Annals Of Surgical Oncology 2025, 1-7. PMID: 40836156, PMCID: PMC12373021, DOI: 10.1245/s10434-025-18089-9.Peer-Reviewed Original ResearchRate of re-excisionRe-excision ratesPhase II trialRe-ExcisionBreast cancer patientsContemporary cohortII trialCancer patientsInitiation of systemic therapyRisk of wound complicationsStandard postoperative approachTumor bed boostWhole breast radiotherapyCompletion of radiotherapyInadequate surgical marginsMedian treatment timeShort durationPostoperative boostLocoregional therapyPostoperative approachDiagnostic biopsySurgical marginsSystemic therapyProspective trialsWound complicationsImpact of Preoperative Radiation Boost on Oncotype DX® Result in a Phase II Clinical Trial
Eladoumikdachi F, Chakraborty M, Ohri N, Kowzun M, Kumar S, Toppmeyer D, Haffty B. Impact of Preoperative Radiation Boost on Oncotype DX® Result in a Phase II Clinical Trial. Annals Of Surgical Oncology 2025, 1-2. PMID: 40634811, DOI: 10.1245/s10434-025-17799-4.Peer-Reviewed Original ResearchDevelopment and validation of a multivariable risk model based on clinicopathological characteristics, mammography, and MRI imaging features for predicting axillary lymph node metastasis in patients with upgraded ductal carcinoma in situ
Cheng M, Wu C, Lin Y, Zou J, Wang D, Haffty B, Wang K. Development and validation of a multivariable risk model based on clinicopathological characteristics, mammography, and MRI imaging features for predicting axillary lymph node metastasis in patients with upgraded ductal carcinoma in situ. Gland Surgery 2025, 14: 73853-73753. PMID: 40405957, PMCID: PMC12093168, DOI: 10.21037/gs-2025-89.Peer-Reviewed Original ResearchAxillary lymph node metastasisDuctal carcinoma in situArea under the curveMedial lateral obliqueMagnetic resonance imagingCarcinoma in situLymph node metastasisArea under the curve valuesClinicopathological characteristicsValidation cohortNode metastasisClinicopathological modelDuctal carcinoma in situ patientsAxillary surgical stagingMRI imaging featuresNon-invasive modelMultivariate regression analysisMagnetic resonance imaging modelMultivariate risk modelAxillary surgerySurgical stagingPeritumoral regionSurgical interventionTraining cohortRetrospective analysisLipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation
Liu J, Shen Y, Liu J, Xu D, Chang C, Wang J, Zhou J, Haffty B, Zhang L, Bargonetti J, De S, Hu W, Feng Z. Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation. Nature Communications 2025, 16: 1762. PMID: 39971971, PMCID: PMC11839913, DOI: 10.1038/s41467-025-57099-9.Peer-Reviewed Original ResearchConceptsGain-of-functionTumor suppressive function of p53Mutp53 accumulationAccumulate to high levelsFunction of p53Mutant p53 accumulationTumor suppressive functionMutant p53Subcutaneous xenograft tumor modelMutp53Promote tumorigenesisP53 accumulationPalmitoylationPotential therapeutic strategyXenograft tumor modelFASNTumor modelTumor organoidsTransgenic miceTherapeutic strategiesP53If We Build It, Why They Do Not Come? An American College of Surgeons National Quality Improvement Collaborative to Understand Barriers to Completion of Cancer Treatment
Janczewski L, Yang A, Reilly E, Chan K, Coates T, Scarlett S, Hedlund S, Snyder R, Haffty B, Shelton C, Kirstein L. If We Build It, Why They Do Not Come? An American College of Surgeons National Quality Improvement Collaborative to Understand Barriers to Completion of Cancer Treatment. JCO Oncology Practice 2025, 21: 1185-1192. PMID: 39928902, DOI: 10.1200/op-24-00745.Peer-Reviewed Original ResearchAccredited cancer programsNational QI collaborativeCancer programsAt-risk patientsQI collaborativeCancer careNational Quality Improvement CollaborativeProportion of at-risk patientsPercentage of at-risk patientsQuality improvementCompletion of cancer treatmentAmerican CollegeNational quality improvementQuality Improvement CollaborativePatients face barriersIdentifying at-risk patientsTests assessed differencesData collection periodUnderstanding barriersIdentified barriersRadiation treatmentCancer-specific outcomesImprove collaborationKruskal-Wallis tests assessed differencesMultiple radiation treatmentsSex-Based Bias in Industry Payments to Medical Oncologists
Jan I, De B, Kwon Y, Freeman R, Larkin K, Subramanian S, Pandu P, Song A, Young M, Sayan M, Beier M, Ludmir E, Vapiwala N, Haffty B, Mattes M. Sex-Based Bias in Industry Payments to Medical Oncologists. JCO Oncology Advances 2025 DOI: 10.1200/oa-24-00029.Peer-Reviewed Original ResearchMedical oncologistsNational Plan and Provider Enumeration SystemIndustry paymentsCenters for MedicareGeneral paymentsResearch paymentsNational Institutes of Health (NIHPractice locationIndustry research paymentsSex-based differencesSpeaker feesOncologistsNo significant sex differencesEnumeration systemSex-based biasOpen Payments DatabaseNIH RePORTERSex-basedInvestigate potential differencesSignificant sex differencesOncology researchResearch fundingPayments Database
2024
Predicting Radiation-Induced Acute Toxicity in Breast Cancer Patients: A Radiogenomic Approach
Wei S, Zhang Y, Sowmiyanarayanan S, Yehia Z, Jan I, Yue N, Haffty B, Nie K. Predicting Radiation-Induced Acute Toxicity in Breast Cancer Patients: A Radiogenomic Approach. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e341. DOI: 10.1016/j.ijrobp.2024.07.752.Peer-Reviewed Original ResearchBreast cancer patientsRadiation dermatitisSide effectsCancer patientsBreast cancer patients treated with radiationRadiogenomic approachCancer patients treated with radiationRadiation-induced acute toxicityPatients treated with radiationRadiomic featuresSingle nucleotide polymorphismsAcute radiation dermatitisBreast-conserving surgeryRadiation side effectsPeripheral blood samplesTotal radiation dosePersonalized treatment strategiesGenetic statusRadiation therapyMammographic patternsRadiomic texture featuresTherapy side effectsClinical parametersRetrospective studyClinical featuresPtcog International Survey of Practice Patterns and Trends in Utilization of Proton Therapy for Breast Cancer
Choi I, Abeloos C, Lozano A, Kim M, Hanlon A, Vargas C, Maduro J, Bradley J, Offersen B, Haffty B, Pankuch M, Amos R, Kim N, Kirova Y, Mutter R. Ptcog International Survey of Practice Patterns and Trends in Utilization of Proton Therapy for Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e742-e743. DOI: 10.1016/j.ijrobp.2024.07.1632.Peer-Reviewed Original ResearchRegional nodal irradiationParticle Therapy Co-Operative GroupBreast cancerBC patientsPractice patternsDose-fractionation regimensHighly-selected patientsProton beam therapyPatient selection criteriaPencil beam scanningFisher's exact testEvolution of practice patternsPatient selection methodsClinical trial enrollmentSurvey of practice patternsImage guidance capabilitiesTreated BC patientsHypofractionated regimensNodal irradiationRecurrent BCBeam therapyPatient selectionProton therapyU.S. CentersExact test