Lynne Regan, PhD
Cards
About
Titles
Professor Emeritus of Molecular Biophysics and Biochemistry and of Chemistry
Appointments
Molecular Biophysics and Biochemistry
EmeritusPrimary
Other Departments & Organizations
- Molecular Biophysics and Biochemistry
- Regan Lab
- Structural Biology
- Yale Cancer Center
- Yale Ventures
Education & Training
- PhD
- Massachusetts Institute of Technology (1987)
Research
Overview
Research interests of the Regan lab encompass protein structure, folding and design; protein-protein interactions and protein-RNA interactions. Our research is problem based, and we use whatever techniques are most appropriate as a particular project develops. Our research ranges from fundamental studies of protein stability to the design of novel protein-based nano-materials. Our interest in protein-protein interactions ranges from the design of proteins with novel binding activities and characterization of their properties using a range of techniques including fluorescence, circular dichroism, surface plasmon resonance, NMR and x-ray crystallography to the specific inhibition of protein-protein interactions in vivo as a route to a novel class of anti-breast cancer agents. Our interest in protein-RNA interactions is focused on structure and function of Fragile X Mental Retardation Protein (FMRP). Fragile X Mental Retardation Syndrome is the most common cause of inherited mental retardation in humans, and is caused by lack of functional FMRP. Here our approaches range from structural studies of FMRP, to whole animal profiling of RNA and protein expression patterns in wild-type versus FMRP knock-out animals.
Medical Subject Headings (MeSH)
Biochemistry; Biophysics; Chemistry; Fragile X Mental Retardation Protein; Fragile X Syndrome; Molecular Biology
Links & Media
News
- August 23, 2016
CaSB@Yale launches with $9.5M federal grant to battle deadliest cancers
- February 27, 2016
MB&B Professor Lynne Regan selected as honoree in the 2016 Women of Innovation® program
- August 10, 2015
Teach Better Podcast--Interview with Professor Lynne Regan
- May 14, 2014
Convergence: Facilitating Transdisciplinary Integration of Life Sciences, Physical Sciences, Engineering, and Beyond