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Molecular Medicine, Pharmacology, and Physiology (MMPP) Track

MMPP Track Leadership

  • Kathryn M. Ferguson

    Co-Director of Graduate Admissions, MMPP Track

    Associate Professor of Pharmacology; Member, Yale Cancer Biology Institute

    Dr. Ferguson’s research focuses on extracellular control of receptor tyrosine kinases (RTKs), aberrant activation of which can drive cancer and other diseases.  Dr. Ferguson obtained her Ph.D. from Yale in 1996, and completed postdoctoral training at the University of Pennsylvania Perelman School of Medicine.  She transitioned to an independent faculty position in the Department of Physiology at UPenn in 2003, returning to Connecticut in 2015 to join the Yale Cancer Biology Institute and Department of Pharmacology.

  • Qin Yan

    Co-Director of Graduate Admissions, MMPP Track

    Associate Professor of Pathology; Director, Epigenetics Program

    Dr. Qin Yan (严钦) is an Associate Professor of Pathology at Yale Medical School and a member of Yale Comprehensive Cancer Center and Yale Stem Cell Center. He directs a research laboratory to elucidate the roles of epigenetic mechanisms that drive tumor initiation and progression and to translate the findings to the clinic. His laboratory has made significant contributions to the understanding of KDM5 H3K4me3/2 histone demethylases. Dr. Yan received his B.S. degree from the University of Science and Technology of China. After his Ph.D. training on regulation of transcription and ubiquitination with Drs. Joan and Ronald Conaway at the Oklahoma Medical Research Foundation and Stowers Institute for Medical Research, he completed his postdoctoral training on cancer biology with Nobel laureate Dr. William Kaelin at the Dana-Farber Cancer Institute and Harvard Medical School. He has received a number of awards including Era of Hope Scholar Award from DoD Breast Cancer Research Program, Stewart Fellow Award and V Scholar Award.

Faculty

  • Nii Addy

    Associate Professor of Psychiatry

    Research Interests
    • Behavioral Sciences
    • Electrochemistry
    • Neurobiology
    • Psychiatry
    • Signal Transduction
    • Substance-Related Disorders
  • Claudio R. Alarcón

    Assistant Professor of Pharmacology

    Research Interests
    • Neoplasm Metastasis

    Our lab uses multidisciplinary approaches to understand the impact of RNA metabolism in development, health and disease. We are primarily focused in identifying the physiological and pathophysiological roles of RNA modifications and non-coding RNAs at the molecular, cellular and organismal levels. Claudio, a native of Chile, obtained his Ph.D. from Cornell University in NYC. He was a postdoctoral fellow at the Rockefeller University before joining Yale University in 2017.

  • Karen Anderson

    Professor of Pharmacology and of Molecular Biophysics and Biochemistry; Co-Leader, Developmental Therapeutics, Yale Cancer Center; Co-Director Therapeutics/Chemotherapy Program

    Research Interests
    • Molecular Biology
    • Pharmacology
    • Anti-Retroviral Agents
    • HIV Reverse Transcriptase
    • Multifunctional Enzymes

    Karen S. Anderson is a Professor of Pharmacology and Molecular Biophysics and Biochemistry. She is involved in teaching undergraduates and graduate students about drug discovery and structure-based drug design. She also serves as an undergraduate research mentor and is a fellow at Pierson College at Yale serving as a undergraduate freshman advisor. Dr. Anderson's research utilizes mechanistic enzymology and structure-based drug design. Her work focuses on understanding how enzymes, playing critical roles in such diseases as cancer and infectious diseases, including AIDS, work at a molecular level. She uses that information to develop new drug therapies. She has trained over 50 undergraduates, graduate students, M.D./Ph.D. students and postdoctoral students who have gone on to graduate school and medical school as well as successful careers in academia and industry and who are involved in biomedical research.




  • Peter S. Aronson

    C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular And Molecular Physiology

    Research Interests
    • Acid-Base Imbalance
    • Cell Membrane Permeability
    • Hyperoxaluria
    • Urinary Tract Physiological Phenomena
    • Water-Electrolyte Imbalance
    • Nephrolithiasis

    Dr. Aronson received his undergraduate education at the University of Rochester and his medical education at New York University. He was an internal medicine resident at the University of North Carolina and a research fellow at the National Institutes of Health before coming to Yale as a renal fellow in 1974. He was Chief of the Section of Nephrology at Yale from 1987-2002. Dr. Aronson has published articles and book chapters on the mechanisms regulating sodium, acid-base, and oxalate excretion by the kidney, particularly as related to the formation of kidney stones. He has received a number of awards for his research work, including the Young Investigator Award of the American Society of Nephrology (ASN) and American Heart Association in 1985, the Homer W. Smith Award of the ASN in 1994, election to the American Academy of Arts and Sciences in 2009, the Robert W. Berliner Award of the American Physiological Society (APS) in 2016, and the Walter B. Cannon Award of the APS in 2019. He served as President of the American Society of Nephrology in 2008. Dr. Aronson actively participates in the teaching of undergraduate, graduate and medical students, as well as residents and fellows. He was a co-recipient of the Charles W. Bohmfalk Teaching Prize in the Basic Sciences in 2005. Dr. Aronson is an Associate Director of the Yale M.D.-Ph.D. Program.

  • Slav Bagriantsev

    Associate Professor of Cellular & Molecular Physiology

    Research Interests
    • Biochemistry
    • Biophysics
    • Ducks
    • Electrophysiology
    • Ion Channels
    • Mechanoreceptors
    • Neurosciences
    • Pacinian Corpuscles
    • Sensory Receptor Cells
    • Trigeminal Ganglion
    • Thermoreceptors
    • Potassium Channels
    • Anseriformes
    • Transient Receptor Potential Channels
    • Voltage-Gated Sodium Channels
  • Allen Bale

    Professor of Genetics; Director, DNA Diagnostic Lab

    Research Interests
    • Congenital Abnormalities
    • DNA
    • Fanconi Syndrome
    • Genetics
    • Congenital, Hereditary, and Neonatal Diseases and Abnormalities
    • Multiple Endocrine Neoplasia
    • Neoplastic Syndromes, Hereditary
    • Skin Neoplasms
  • Choukri Ben Mamoun

    Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis

    Research Interests
    • Babesiosis
    • Malaria
    • Opportunistic Infections
    • Protozoan Infections
    • Infectious Disease Medicine
  • Jeffrey Bender

    Robert I. Levy Professor of Medicine (Cardiology) and Professor of Immunobiology; Associate Chief, Cardiovascular Medicine, Internal Medicine; Director, Yale Cardiovascular Research Center, Internal Medicine

    Research Interests
    • Cardiology
    • Endothelium
    • Immune System
    • Inflammation
    • Macrophages
    • T-Lymphocytes
    • RNA Stability
  • Anton Bennett

    Dorys McConnell Duberg Professor of Pharmacology and Professor of Comparative Medicine; Co-Director, Program in Integrative Cell Signaling and Neurobiology of Metabolism; Director, BBS Minority Affairs

  • Ranjit S. Bindra

    Associate Professor of Therapeutic Radiology

    Research Interests
    • DNA Repair
    • Glioma
    • Medical Oncology
    • Pediatrics
    • Radiology
    • Therapeutics
    • Central Nervous System Neoplasms
    • Radiation Oncology
    • Genomics
    • High-Throughput Screening Assays
  • Titus Boggon

    Associate Professor of Pharmacology and of Molecular Biophysics and Biochemistry

    Research Interests
    • Biochemistry
    • Crystallography
    • Molecular Biology
    • Protein Kinases
    • Substrate Specificity
    • Signal Transduction
    • Hemangioma, Cavernous, Central Nervous System

    Dr. Boggon is a structural biologist interested in the molecular basis of cytosolic signal transduction cascades. He completed his Ph.D. at the University of Manchester, U.K., and postdoctoral studies at Mount Sinai School of Medicine, Columbia University and the Dana-Farber Cancer Institute (at Harvard Medical School). His lab is interested in understanding how RhoGTPase signal transduction pathways are regulated at the molecular level, and the molecular basis for acquisition of cerebrovascular disorders.

  • Angelique Bordey

    Professor of Neurosurgery and of Cellular And Molecular Physiology; Co Vice Chair of Research, Neurosurgery

    Research Interests
    • Autistic Disorder
    • Central Nervous System Diseases
    • Nervous System Malformations
    • Nervous System Diseases
    • Neurologic Manifestations
    • Neurosurgery
    • Physiology
    • Stem Cells
    • Diseases

    Dr. Angélique Bordey holds the rank of Professor of Neuroscience. Dr. Bordey is an active participant in teaching and training of graduate and medical students at Yale School of Medicine. Dr. Bordey is the Editor-in-Chief of the journal Frontiers in Neurogenesis and an executive Editor of the journals Neuropharmacology, Glia, Neuroplasticity, AES Neuro, Neurogenesis, and Fronteirs in Neuroscience. She has served as an Ad Hoc member on several study sections and is presently a member of CMBG NIH study section . She has organized several national and international symposiums, and is frequently an invited speaker. Finally, she is a McKnight awardee and holds several grant fundings.

  • Marcus Bosenberg

    Professor of Dermatology, Pathology, and Immunobiology; Co-Leader, Genetics, Genomics and Epigenetics, Yale Cancer Center; Interim Director, Yale Center for Immuno-Oncology; Director, Yale SPORE in Skin Cancer

    Research Interests
    • Cell Biology
    • Dermatology
    • Melanoma
    • Neoplasm Metastasis
    • Pathology

    Marcus Bosenberg M.D., Ph.D., is a physician scientist who directs a leading melanoma research laboratory, is Co-Leader of the Genomics, Genetics and Epigenetics Program of the Yale Cancer Center, Director of the Yale SPORE in Skin Cancer, and is a practicing dermatopathologist at Yale Dermatopathology through Yale Medicine.

    In his research, Dr. Bosenberg studies the genetics and cellular changes that result in melanoma, the leading cause of skin cancer deaths. His laboratory has developed several widely utilized mouse models in order to study how melanoma forms and progresses, to test new melanoma therapies, and how the immune system can be stimulated to fight melanoma. He works to translate basic scientific findings into improvements in melanoma diagnosis and therapy. He has published over 100 peer-reviewed articles, is a member of the Yale Cancer Center Executive Committee, and is a faculty member of the Raymond and Beverly Sackler Institute for Biological, Physical, and Engineering Sciences.

    Dr. Bosenberg mentors undergraduate, graduate, medical, and MD-PhD students in his laboratory, teaches at Yale School of Medicine, and trains resident physicians, fellows, and postdoctoral fellows.

  • Demetrios Braddock

    Associate Professor of Pathology

    Research Interests
    • Calcification, Physiologic
    • Osteoarthropathy, Primary Hypertrophic
    • Pathology
    • Pseudoxanthoma Elasticum
    • Sickle Cell Trait
    • Rare Diseases
    • Vascular Calcification

    Demetrios Braddock was born in Tennessee, educated at the University of Chicago, trained at the NIH in Anatomic Pathology and Biophysical Chemistry, and came to Yale in 2004. He practices Hematopathology and leads a laboratory that studies the ENPP enzymes – a family of extracellular enzymes regulating hemostasis, bone mineralization, and vascular development. These studies have progressed to the development of biologic therapeutics for vascular calcification disorders.

  • Richard Bucala

    Waldemar Von Zedtwitz Professor of Medicine (Rheumatology) and Professor of Pathology and of Epidemiology (Microbial Diseases); Chief, Rheumatology, Allergy, & Immunology

    Research Interests
    • Africa
    • Epidemiology
    • Macrophage Migration-Inhibitory Factors
    • Malaria
    • Pathology
    • Public Health
    • Rheumatology
    • Stem Cells
    • Global Health
    • Communicable Diseases, Emerging
    • Infectious Disease Medicine

    Richard Bucala, MD, PhD, is a Professor of Medicine, Pathology, and Epidemiology & Public Health.  He studies the mechanisms by which protective immune responses lead to immunopathology, focusing on MIF-family cytokines and their genetics, which his group first cloned and characterized experimentally.  Currently, his laboratory is leading multidisciplinary efforts to develop immunotherapies tailored to an individual’s genetic makeup. An anti-MIF developed by the group is undergoing clinical testing in oncology, and an anti-MIF receptor antibody, recently FDA approved, is under evaluation in SLE. Dr. Bucala also is credited with the discovery of the fibrocyte, which is being targeted therapeutically in different fibrosing disorders.  He is a co-founder of Cytokine Networks and of MIFCOR, a biotechnology startup begun as a student-advised project.  Dr. Bucala was elected to the American Society for Clinical Investigation and the Association of American Physicians. He is the Editor-in-Chief of Arthritis & Rheumatology and has served on numerous advisory boards for the NIH, the pharmaceutical industry, academia, and private foundations.

  • Cecilia Canessa

    Professor of Cellular And Molecular Physiology

    Research Interests
    • Central Nervous System
    • Electrophysiology
    • Kidney
    • Nephrology
    • Physiology
    • Epithelial Sodium Channels
  • Lloyd G. Cantley

    C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular And Molecular Physiology; Vice Chair, Research; Co-director of Education, Yale Center for Clinical Investigation

    Research Interests
    • Epithelial Cells
    • Kidney
    • Macrophages
    • Morphogenesis
    • Nephrology
    • Physiology

    Dr. Cantley performed his clinical Internal Medicine training at the University of North Carolina followed by Nephrology fellowship training at the Beth Israel and Brigham and Women's Hospitals in Boston. He then entered research training at Harvard in the laboratories of Dr. Franklin Epstein and Dr. Guido Guidotti before accepting a faculty position at the Beth Israel. In 2000 Dr. Cantley moved from Harvard to Yale where he established his research focus on the reparative tubular responses to kidney injury.

  • Michael Caplan

    C. N. H. Long Professor of Cellular And Molecular Physiology and Professor of Cell Biology; Chair, Cellular and Molecular Physiology

    Research Interests
    • Cell Biology
    • Epithelial Cells
    • Kidney
    • Polycystic Kidney Diseases
    • Physiology
    • Ion Pumps

    Michael J. Caplan received his bachelors degree from Harvard University and his M.D. and Ph.D. degrees from Yale University in 1987. He joined Yale's Department of Cellular and Molecular Physiology as a faculty member in 1988, and is currently the C.N.H. Long Professor of Cellular and Molecular Physiology and Cell Biology.

    He has received fellowships from the Helen Hay Whitney Foundation, the David and Lucille Packard Foundation for Science and Engineering, and a National Young Investigator Award from the National Science Foundation. He has also received the Young Investigator Awards from the American Physiological Society and the American Society of Nephrologists.

    His work focuses on understanding the ways in which kidney cells organize and maintain their unique structures. His laboratory also studies the mechanisms responsible for Autosomal Dominant Polycystic Kidney Disease, and is working to identify targets for new therapies.