Dustin Scheinost, PhD, BS
Associate Professor of Radiology and Biomedical ImagingCards
About
Research
Publications
2025
Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Months post-traumaFunctional magnetic resonance imagingTrauma survivorsDSM-5Post-traumaPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptom severityPosttraumatic stress disorder symptom trajectoriesPosttraumatic stress disorder severityTask-based fMRI dataAnterior default modePredictive of symptomsFollow-up assessmentDevelopment of effective personalized treatmentsComprehensive clinical assessmentClinician-AdministeredNeurobiological indicesPosttraumatic psychopathologyHyperarousal symptomsCentral executiveTrauma exposureSalience networkConnectome-based predictive modeling of early and chronic psychosis symptoms
Foster M, Ye J, Powers A, Dvornek N, Scheinost D. Connectome-based predictive modeling of early and chronic psychosis symptoms. Neuropsychopharmacology 2025, 1-9. PMID: 40016363, DOI: 10.1038/s41386-025-02064-9.Peer-Reviewed Original ResearchConnectome-based predictive modelingPositive and Negative Syndrome ScalePsychosis symptomsSymptom networksSymptom severityBrain networksNeural correlates of CPResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingNegative Syndrome ScaleIdentified group differencesPredicted effect sizeCorrelates of CPGeneral psychopathologyNegative symptomsPositive symptomsSyndrome ScaleFrontoparietal networkNeural correlatesVirtual lesion analysisGroup differencesConnectivity changesEffect sizeLesion analysisLongitudinal studyPREDICTING DEPRESSED AND ELEVATED MOOD SYMPTOMATOLOGY IN BIPOLAR DISORDER USING BRAIN FUNCTIONAL CONNECTOMES
Sankar *, Shen X, Colic L, Goldman D, Villa L, Kim J, Pittman B, Scheinost D, Constable R, Blumberg H. PREDICTING DEPRESSED AND ELEVATED MOOD SYMPTOMATOLOGY IN BIPOLAR DISORDER USING BRAIN FUNCTIONAL CONNECTOMES. The International Journal Of Neuropsychopharmacology 2025, 28: i15-i15. PMCID: PMC11814904, DOI: 10.1093/ijnp/pyae059.027.Peer-Reviewed Original ResearchConnectome-based predictive modelingBipolar disorderMood symptomatologyMood symptomsFunctional connectomeYoung Mania Rating ScaleFunctional magnetic resonance imaging dataPredictors of functional impairmentEmotion processing taskMania Rating ScaleMood symptom severityMood symptom scoresBrain functional connectomeMagnetic resonance imaging dataBrain function disturbancesHamilton DepressionPredicting depressionSymptom severityRating ScaleFunctional impairmentDisordersMoodSymptomatologyProcessing tasksDepressionInfant sleep state coded from respiration and its relationship to the developing functional connectome: A feasibility study
Mueller I, Rodriguez R, Pini N, Holland C, Ababio R, Inala S, Delapenha K, Mahmoodi V, Khaitova M, Hao X, Fifer W, Scheinost D, Spann M. Infant sleep state coded from respiration and its relationship to the developing functional connectome: A feasibility study. Developmental Cognitive Neuroscience 2025, 72: 101525. PMID: 39965287, PMCID: PMC11876745, DOI: 10.1016/j.dcn.2025.101525.Peer-Reviewed Original ResearchEmbracing Model Heterogeneity for Better Brain-Behavior Associations
Scheinost D, Spann M. Embracing Model Heterogeneity for Better Brain-Behavior Associations. Biological Psychiatry Global Open Science 2025, 5: 100425. PMID: 40018658, PMCID: PMC11867123, DOI: 10.1016/j.bpsgos.2024.100425.Peer-Reviewed Original ResearchModality-level obstacles and initiatives to improve representation in fetal, infant, and toddler neuroimaging research samples
Margolis E, Nelson P, Fiske A, Champaud J, Olson H, Gomez M, Dineen Á, Bulgarelli C, Troller-Renfree S, Donald K, Spann M, Howell B, Scheinost D, Korom M. Modality-level obstacles and initiatives to improve representation in fetal, infant, and toddler neuroimaging research samples. Developmental Cognitive Neuroscience 2025, 72: 101505. PMID: 39954600, PMCID: PMC11875194, DOI: 10.1016/j.dcn.2024.101505.Peer-Reviewed Original ResearchConceptsFunctional near-infrared spectroscopyEarly brain developmentNeurobiological vulnerabilityNeuroimaging researchModality-specificNeuroimaging techniquesNeurodevelopmental processesNeuroimaging modalitiesBrain developmentResearch sampleMagnetic resonance imagingNear-infrared spectroscopyEquitable representationMarginalized communitiesExcluded peopleStudy early brain developmentToddlersCranial ultrasonographyResonance imagingInsufficient resourcesTangible solutionsEarly markersNeural Variability and Cognitive Control in Individuals With Opioid Use Disorder
Ye J, Mehta S, Peterson H, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Yip S, Hahn C, Lacadie C, Greene A, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D. Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder. JAMA Network Open 2025, 8: e2455165. PMID: 39821393, PMCID: PMC11742521, DOI: 10.1001/jamanetworkopen.2024.55165.Peer-Reviewed Original ResearchConceptsDecreased cognitive controlCognitive controlOpioid use disorderCueing paradigmResting-stateHC participantsUse disorderBrain statesBrain dynamicsHealthy controlsNeural mechanismsCognitive processesNeural variabilityFMRIBehavioral implicationsImpaired abilityBrainAccuracy scoresMagnetic resonance imagingDynamic alterationsParticipantsCase-control studyDisordersParadigmImpacts millionsErratum for: Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder.
Mehta S, Peterson H, Ye J, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Yip S, Hahn C, Lacadie C, Greene A, Jeon S, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D. Erratum for: Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder. Radiology 2025, 314: e249023. PMID: 39873610, PMCID: PMC11788710, DOI: 10.1148/radiol.249023.Peer-Reviewed Original Research
2024
Pain can’t be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design
Barron D, Saltoun K, Kiesow H, Fu M, Cohen-Tanugi J, Geha P, Scheinost D, Isaac Z, Silbersweig D, Bzdok D. Pain can’t be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design. BMC Medicine 2024, 22: 594. PMID: 39696368, PMCID: PMC11656997, DOI: 10.1186/s12916-024-03807-z.Peer-Reviewed Original ResearchConceptsChronic diseasesPain ProfileChronic conditionsPatient functionPain conditionsManagement of chronic diseasesChronic disease managementContinuum of careHealthcare delivery systemImprove quality of lifeQuality of lifePainful body partPain interferenceAssociated with clinical variablesUK BiobankWhole-body perspectiveHealth strategiesTreatment of individual patientsPain intensityClinically relevant differencesPatient wellbeingPain managementTreat painful conditionsICD codesMedical specialtiesAlterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder.
Mehta S, Peterson H, Ye J, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Yip S, Hahn C, Lacadie C, Greene A, Jeon S, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D. Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder. Radiology 2024, 313: e240514. PMID: 39656127, PMCID: PMC11694074, DOI: 10.1148/radiol.240514.Peer-Reviewed Original ResearchConceptsHealthy control participantsRight medial temporal lobeOpioid use disorderFunctional brain alterationsMedial temporal lobeOpioid use disorder groupFunctional connectivityUse disorderControl participantsBrain alterationsIntrinsic resting-state functional connectivityTemporal lobeMedial prefrontal cortex volumesVoxel-wise linear regressionT1-weighted MRIResting-state functional connectivityFamily-wise error correctionPrefrontal cortex volumeResting-state functional MRIIncreased functional connectivityIntrinsic connectivity distributionFunctional MRI studiesFemale participantsRegional brain volumesAssess group differences
Clinical Trials
Current Trials
Brain Imaging Study of Emotion Regulation in Children
HIC ID2000031303RoleSub InvestigatorPrimary Completion Date11/30/2023Recruiting ParticipantsGenderBothAge5 years - 15 yearsStudying the Adult Brain
HIC ID2000025671RoleSub InvestigatorPrimary Completion Date07/31/2025Recruiting ParticipantsGenomic Basis of Neurodevelopmental and Brain Outcomes in Congenital Heart Disease (CHD Brain and Genes)
HIC ID2000020449RoleSub InvestigatorPrimary Completion Date12/31/2027Recruiting ParticipantsGenderBothAge8+ yearsStudy of Brain Function Across the Lifespan
HIC ID2000020891RoleSub InvestigatorPrimary Completion Date07/31/2022Recruiting ParticipantsGenderBothAge18 years - 65 years
News
News
- April 09, 2025
Inflammation May Be the Link Between Chronic Pain and Depression
- April 08, 2025
Understanding the Transition From Early to Chronic Psychosis
- March 10, 2025Source: Yale News
Machine Learning Model Predicts PTSD Symptom Severity Over Time
- December 10, 2024Source: Yale News
Opioid Use Disorder is Associated With Changes in Brain Structure, Function
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Mailing Address
Bioimaging Sciences
300 cedar st
New Haven, CT 06520
United States