Hao Yuan Kueh, PhD
Associate Professor of ImmunobiologyDownloadHi-Res Photo
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Appointments
Immunobiology
Primary
Contact Info
Yale Center for Systems and Engineering Immunology (CSEI)
100 College St, Rm 1152
New Haven, CT 06511
United States
About
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Titles
Associate Professor of Immunobiology
Biography
The Kueh Lab seeks to elucidate the molecular circuitry controlling immune cell development and function, and to leverage these principles to engineer next-generation immune cell therapies. Our goal is to build a quantitative, biophysical understanding of immune cell circuit dynamics and design, enabling us to reprogram these circuits in a robust and controllable manner.
To meet this challenge, we measure, manipulate, and model the dynamic behavior of immune cell circuits both in vitro and in animal models, using approaches that are quantitative, single-cell resolved, and high-throughput. These include live-cell imaging, single-cell genomics, and pooled screening strategies. We also apply synthetic biology to construct and rewire immune control circuits, with the aim of equipping immune cells with novel or enhanced functional and therapeutic capabilities.
Last Updated on September 27, 2025.
Appointments
Immunobiology
Associate Professor TenurePrimary
Other Departments & Organizations
- Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS)
- Cancer Immunology
- Computational Biology and Biomedical Informatics
- Human and Translational Immunology Program
- Immunobiology
- Immunology
- Yale Cancer Center
- Yale Center for Systems and Engineering Immunology (CSEI)
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Stem Cell Center
Education & Training
- Postdoctoral Scholar
- California Institute of Technology (2016)
- PhD
- Harvard University, Biophysics (2008)
- AB
- Princeton University, Physics (2002)
Research
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Overview
Medical Research Interests
Adaptive Immunity; Computational Biology; Gene Regulatory Networks; Hematopoietic Stem Cells; Immunity, Innate; Immunologic Memory; Lymphoid Progenitor Cells; Myeloid Progenitor Cells; Single-Cell Analysis; Systems Biology
Public Health Interests
Cancer; Genetics, Genomics, Epigenetics; Immunology
ORCID
0000-0001-6272-6673- View Lab Website
Kueh lab
Publications
Featured Publications
Proofreading and single-molecule sensitivity in T cell receptor signaling by condensate nucleation
White W, Yirdaw H, Ben-Sasson A, Groves J, Baker D, Kueh H. Proofreading and single-molecule sensitivity in T cell receptor signaling by condensate nucleation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2422787122. PMID: 40445763, PMCID: PMC12146730, DOI: 10.1073/pnas.2422787122.Peer-Reviewed Original ResearchCitationsAltmetricReversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision
Abadie K, Clark E, Valanparambil R, Ukogu O, Yang W, Daza R, Ng K, Fathima J, Wang A, Lee J, Nasti T, Bhandoola A, Nourmohammad A, Ahmed R, Shendure J, Cao J, Kueh H. Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision. Immunity 2024, 57: 271-286.e13. PMID: 38301652, PMCID: PMC10922671, DOI: 10.1016/j.immuni.2023.12.006.Peer-Reviewed Original ResearchCitationsAltmetricAntigen perception in T cells by long-term Erk and NFAT signaling dynamics
Wither M, White W, Pendyala S, Leanza P, Fowler D, Kueh H. Antigen perception in T cells by long-term Erk and NFAT signaling dynamics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2308366120. PMID: 38113261, PMCID: PMC10756264, DOI: 10.1073/pnas.2308366120.Peer-Reviewed Original ResearchCitationsAltmetricUnsupervised discovery of dynamic cell phenotypic states from transmitted light movies
Nguyen P, Chien S, Dai J, Monnat R, Becker P, Kueh H. Unsupervised discovery of dynamic cell phenotypic states from transmitted light movies. PLOS Computational Biology 2021, 17: e1009626. PMID: 34968384, PMCID: PMC8754342, DOI: 10.1371/journal.pcbi.1009626.Peer-Reviewed Original ResearchCitationsAltmetricTunable, division-independent control of gene activation timing by a polycomb switch
Pease N, Nguyen P, Woodworth M, Ng K, Irwin B, Vaughan J, Kueh H. Tunable, division-independent control of gene activation timing by a polycomb switch. Cell Reports 2021, 34: 108888. PMID: 33761349, PMCID: PMC8024876, DOI: 10.1016/j.celrep.2021.108888.Peer-Reviewed Original ResearchCitationsAltmetric
2026
Design of solubly expressed miniaturized SMART MHCs
White W, Bai H, Kim C, Jude K, Sun R, Guerrero L, Han X, Chen X, Chaudhuri A, Bonzanini J, Sun Y, Onwuka A, Wang N, Wang C, Nygren P, Li X, Goreshnik I, Allen A, Levine P, Kueh H, Jewett M, Sgourakis N, Achour A, Garcia K, Baker D. Design of solubly expressed miniaturized SMART MHCs. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2505932123. PMID: 41481462, PMCID: PMC12773744, DOI: 10.1073/pnas.2505932123.Peer-Reviewed Original ResearchCitationsAltmetric
2025
Design of a potent interleukin-21 mimic for cancer immunotherapy
Chun J, Lim B, Roy S, Walsh M, Abhiraman G, Zhangxu K, Atajanova T, Revach O, Clark E, Li P, Palin C, Khanna A, Tower S, Kureshi R, Hoffman M, Sharova T, Lawless A, Cohen S, Boland G, Nguyen T, Peprah F, Tello J, Liu S, Kim C, Shin H, Quijano-Rubio A, Jude K, Gerben S, Murray A, Heine P, DeWitt M, Ulge U, Carter L, King N, Silva D, Kueh H, Kalia V, Sarkar S, Jenkins R, Garcia K, Leonard W, Dougan M, Dougan S, Baker D. Design of a potent interleukin-21 mimic for cancer immunotherapy. Science Immunology 2025, 10: eadx1582-eadx1582. PMID: 41004565, PMCID: PMC12768534, DOI: 10.1126/sciimmunol.adx1582.Peer-Reviewed Original ResearchCitationsAltmetricAn early precursor CD8+ T cell that adapts to acute or chronic viral infection
McManus D, Valanparambil R, Medina C, Scharer C, McGuire D, Sobierajska E, Hu Y, Chang D, Wieland A, Lee J, Nasti T, Hashimoto M, Ross J, Prokhnevska N, Cardenas M, Gill A, Clark E, Abadie K, Kumar A, Kaye J, Au-Yeung B, Kueh H, Kissick H, Ahmed R. An early precursor CD8+ T cell that adapts to acute or chronic viral infection. Nature 2025, 640: 772-781. PMID: 39778710, DOI: 10.1038/s41586-024-08562-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAcute DiseaseAdoptive TransferAnimalsCD8-Positive T-LymphocytesCell DifferentiationChronic DiseaseDisease Models, AnimalFemaleHepatocyte Nuclear Factor 1-alphaImmunologic MemoryLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMaleMiceMice, Inbred C57BLPersistent InfectionProgrammed Cell Death 1 Receptor
2024
A timed epigenetic switch balances T and ILC lineage proportions in the thymus
Pease N, Denecke K, Chen L, Gerges P, Kueh H. A timed epigenetic switch balances T and ILC lineage proportions in the thymus. Development 2024, 151: dev203016. PMID: 39655434, PMCID: PMC11664168, DOI: 10.1242/dev.203016.Peer-Reviewed Original ResearchCitationsAltmetric
2021
Scalable control of developmental timetables by epigenetic switching networks
Nguyen P, Pease N, Kueh H. Scalable control of developmental timetables by epigenetic switching networks. Journal Of The Royal Society Interface 2021, 18: 20210109. PMID: 34283940, PMCID: PMC8292019, DOI: 10.1098/rsif.2021.0109.Peer-Reviewed Original ResearchCitationsAltmetric
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Yale Center for Systems and Engineering Immunology (CSEI)
100 College St, Rm 1152
New Haven, CT 06511
United States