2023
Adjusting for population stratification in polygenic risk score analyses: a guide for model specifications in the UK Biobank
Lin B, Pries L, van Os J, Luykx J, Rutten B, Guloksuz S. Adjusting for population stratification in polygenic risk score analyses: a guide for model specifications in the UK Biobank. Journal Of Human Genetics 2023, 68: 653-656. PMID: 37188914, DOI: 10.1038/s10038-023-01161-1.Peer-Reviewed Original ResearchMeSH KeywordsBiological Specimen BanksDepressive Disorder, MajorGenome-Wide Association StudyHumansMultifactorial InheritancePhenotypeRisk FactorsUnited KingdomAssociations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia
Lin B, Pinzón-Espinosa J, Blouzard E, van der Horst M, Okhuijsen-Pfeifer C, van Eijk K, Guloksuz S, Peyrot W, Luykx J, Hasan A, Wagner E, Pantelis C, Everall I, Ayhan Y, Babaoğlu M, Bak M, Alink W, Beld E, Bouhuis A, Edlinger M, Erdoğan I, Gutwinski S, Hallikainen T, Jeger-land E, Lähteenvuo M, de Koning M, Morgenroth C, Müderrisoğlu A, Oviedo-Salcedo T, Schreiter S, Repo-Tiihonen E, Tuppurainen H, Veereschild M, Veerman S, de Vos M, Cohen D, Bogers J, Anıl Yağcıoğlu A, Tiihonen J, Ripke S, Bousman C, Van Beek H, Okhuijsen-Pfeifer C, van der Horst M, van Eijk K, Ertuğrul A, Yoca G, Görlitz T, Grootens K, Leucht S, Narang A, Schneider-Thoma J, Kahn R, Bekema E, Kleymann P, Luykx J, Alizadeh B, van Amelsvoort T, Cahn W, de Haan L, Schirmbeck F, Simons C, van Os J, Rutten B, van Winkel R. Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia. JAMA Psychiatry 2023, 80: 181-185. PMID: 36542388, PMCID: PMC9857760, DOI: 10.1001/jamapsychiatry.2022.4234.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntipsychotic AgentsClozapineFemaleHumansMultifactorial InheritancePsychotic DisordersRisk FactorsSchizophreniaConceptsSchizophrenia spectrum disordersRisk ratioPolygenic risk scoresUnrelated healthy controlsRisk scorePRS-SCZClozapine useHealthy controlsOdds ratioCourse of illnessHigher likelihoodPsychosis liabilityClozapine prescribingClozapine prescriptionPharmacotherapy choicesClozapine treatmentObservational cohortMedication useAntipsychotic useAntipsychotic treatmentMAIN OUTCOMEMultinomial logistic regressionPrognostic studiesAntipsychoticsEarly intervention
2022
Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype?
Fusar-Poli L, Rutten B, van Os J, Aguglia E, Guloksuz S. Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype? International Review Of Psychiatry 2022, 34: 663-675. PMID: 36786114, DOI: 10.1080/09540261.2022.2101352.Peer-Reviewed Original ResearchMeSH KeywordsGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMental DisordersMultifactorial InheritancePsychiatryRisk FactorsConceptsPolygenic risk scoresTreatment responseRisk scoreMental disordersDetailed clinical characterizationPresent narrative reviewPotential clinical utilityMajor mental disordersIndividual genetic predispositionRisk stratificationPrognostic evaluationClinical characterizationWide association study datasetsClinical utilityGeneral populationGenetic predispositionNarrative reviewSingle nucleotide polymorphisms
2021
Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status
Pasman J, Demange P, Guloksuz S, Willemsen A, Abdellaoui A, ten Have M, Hottenga J, Boomsma D, de Geus E, Bartels M, de Graaf R, Verweij K, Smit D, Nivard M, Vink J. Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status. Behavior Genetics 2021, 52: 92-107. PMID: 34855049, PMCID: PMC8860781, DOI: 10.1007/s10519-021-10094-4.Peer-Reviewed Original ResearchMeSH KeywordsGenome-Wide Association StudyHumansMultifactorial InheritanceNetherlandsSmokingSocial ClassConceptsLifetime smokingSocioeconomic statusNetherlands Mental Health SurveyMental healthIncidence Study-2Mental Health SurveyNeighborhood socioeconomic statusGenome-wide association studiesGenetic liabilityHealth SurveySmokingGene-environment interactionsEducational attainmentEA effectNetherlands Twin RegisterSmoking traitsGenetic riskPolygenic scoresEtiology of smokingPredictive profilesTwin RegisterSES characteristicsUK BiobankReliable predictorHealthInterrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness
Luykx J, Loef D, Lin B, van Diermen L, Nuninga J, van Exel E, Oudega M, Rhebergen D, Schouws S, van Eijndhoven P, Verwijk E, Schrijvers D, Birkenhager T, Ryan K, Arts B, van Bronswijk S, Kenis G, Schurgers G, Baune B, Arns M, van Dellen E, Somers M, Sommer I, Boks M, Gülöksüz S, McLoughlin D, Dols A, Rutten B. Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness. Biological Psychiatry 2021, 91: 531-539. PMID: 34955169, DOI: 10.1016/j.biopsych.2021.10.013.Peer-Reviewed Original ResearchMeSH KeywordsAntidepressive AgentsDepressive Disorder, MajorElectroconvulsive TherapyHumansMultifactorial InheritanceSchizophreniaTreatment OutcomeConceptsMajor depressive episodeHamilton Depression Rating Scale scoresDepression Rating Scale scoresRating Scale scoresPolygenic risk scoresPRS-SCZECT outcomeElectroconvulsive therapyScale scoreSevere major depressive episodeUnipolar major depressive episodeMajor depressive disorderSecondary outcomesAntidepressant responseECT treatmentDepressive episodeSubgroup analysisECT effectivenessPsychotic featuresDepressive disorderTreatment responseMAIN OUTCOMEEffective treatmentRisk scoreTherapy effectiveness
2020
Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum
Pries L, Dal Ferro G, van Os J, Delespaul P, Kenis G, Lin B, Luykx J, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Alizadeh B, van Amelsvoort T, Bruggeman R, Cahn W, de Haan L, Rutten B, Luykx J, van Os J, van Winkel R, Arango C, O'Donovan M, Tosato S, Rutten B, Guloksuz S. Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum. Epidemiology And Psychiatric Sciences 2020, 29: e182. PMID: 33200977, PMCID: PMC7681168, DOI: 10.1017/s2045796020000943.Peer-Reviewed Original ResearchEvidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway
van Os J, Pries L, Have M, de Graaf R, van Dorsselaer S, Delespaul P, Bak M, Kenis G, Lin B, Luykx J, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, Guloksuz S. Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway. Psychological Medicine 2020, 52: 1910-1922. PMID: 33070791, DOI: 10.1017/s0033291720003748.Peer-Reviewed Original ResearchMeSH KeywordsDelusionsHallucinationsHumansMultifactorial InheritancePsychotic DisordersRiskSchizophreniaConceptsSchizophrenia spectrum disordersChildhood adversityRisk factorsNEMESIS-2Affective dysregulationNon-genetic risk factorsSignificant depressive symptomsSample of patientsRepresentative general population sampleGenetic risk factorsGeneral population sampleSchizophrenia polygenic riskPsychosis outcomesSpectrum disorderDepressive symptomsPRS-SZPolygenic riskDysregulationPatientsPopulation samplePsychosisAffective pathwayDisordersHallucinatory experiencesDelusional ideationDo Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health?
Marsman A, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Kenis G, Lin B, Luykx J, Rutten B, Guloksuz S, van Os J. Do Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health? Schizophrenia Bulletin 2020, 46: 1353-1362. PMID: 33259628, PMCID: PMC7707067, DOI: 10.1093/schbul/sbaa086.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdverse Childhood ExperiencesAgedFamilyFemaleGenetic Predisposition to DiseaseHealth SurveysHumansLife Change EventsLongitudinal StudiesMaleMarijuana UseMiddle AgedMultifactorial InheritanceNetherlandsPsychotic DisordersSchizophreniaSocioeconomic FactorsUrban PopulationYoung AdultConceptsPolygenic risk scoresSchizophrenia polygenic risk scoresMental healthFamily historyNetherlands Mental Health SurveyPopulation-based studyPolygenic riskChildhood traumaMental Health SurveyMental health changesEnvironmental risk factorsGeneral mental healthPopulation mental healthGeneral population sampleSomatic painRisk factorsHealth SurveyRisk scorePRS-SZBipolar disorderEpidemiological settingsMental disordersHealth changesAttributable variationPainPolygenic liability for schizophrenia and childhood adversity influences daily‐life emotion dysregulation and psychosis proneness
Pries L, Klingenberg B, Menne‐Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Cinar O, Lin B, Luykx J, Rutten B, van Os J, Guloksuz S. Polygenic liability for schizophrenia and childhood adversity influences daily‐life emotion dysregulation and psychosis proneness. Acta Psychiatrica Scandinavica 2020, 141: 465-475. PMID: 32027017, PMCID: PMC7318228, DOI: 10.1111/acps.13158.Peer-Reviewed Original ResearchConceptsDaily life stressorsChildhood adversityEmotion dysregulationPositive affectPsychosis pronenessMomentary mental statesEcological momentary assessmentChildhood Trauma QuestionnaireGene-environment correlationNegative affectMental statesMomentary assessmentPsychosis expressionTrauma QuestionnaireAdversityAffectYoung adultsStressorsNovel evidencePolygenic liabilityInteraction effectsPronenessSchizophreniaHigh PRSState domain
2019
Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study
van Os J, Pries L, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, Guloksuz S. Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study. Psychological Medicine 2019, 50: 1884-1897. PMID: 31414981, DOI: 10.1017/s003329171900196x.Peer-Reviewed Original ResearchConceptsPsychotic disordersPolygenic riskSchizophrenia polygenic riskGene-environment interactionsGenetic riskRelatives of patientsFirst-degree relativesPsychosis phenotypeAverage genetic riskIntermediate phenotypesHealthy siblingsCognitive intermediate phenotypesControl groupAnalysis of associationAverage riskPatientsToward incorporating genetic risk scores into symptom networks of psychosis
Isvoranu A, Guloksuz S, Epskamp S, van Os J, Borsboom D, Investigators. Toward incorporating genetic risk scores into symptom networks of psychosis. Psychological Medicine 2019, 50: 636-643. PMID: 30867074, PMCID: PMC7093319, DOI: 10.1017/s003329171900045x.Peer-Reviewed Original Research
2017
Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience
van Os J, van der Steen Y, Islam M, Gülöksüz S, Rutten B, Simons C. Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine 2017, 47: 2421-2437. PMID: 28436345, DOI: 10.1017/s0033291717000915.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresHealthy comparison subjectsPsychotic disordersAttribution of salienceAffective episodesComparison subjectsIntelligence quotientTotal scorePolygenic riskFirst-degree relativesElevated genetic riskLower intelligence quotientManic episodesHealthy relativesRisk scoreNeurodevelopmental alterationsDepression subscaleLifetime ratesSimilar associationPsychosis riskFloor effectsGenetic riskPositive subscalePsychosis phenotypeDisorders