Halima Chahboune, PhD
Executive Director, Carol and Gene Ludwig ProgramCards
About
Titles
Executive Director, Carol and Gene Ludwig Program
Departments & Organizations
- Ludwig Program for Neuroimmunity in Dementia
- Neuroscience
- Quantitative Neuroscience with Magnetic Resonance
Education & Training
- PhD
- Universite Claude Bernard (2003)
Advanced Training & Certifications
- Management Development Certificate Program
- Princeton University (2020)
Research
Publications
2013
Induced clustered nanoconfinement of superparamagnetic iron oxide in biodegradable nanoparticles enhances transverse relaxivity for targeted theranostics
Ragheb RR, Kim D, Bandyopadhyay A, Chahboune H, Bulutoglu B, Ezaldein H, Criscione JM, Fahmy TM. Induced clustered nanoconfinement of superparamagnetic iron oxide in biodegradable nanoparticles enhances transverse relaxivity for targeted theranostics. Magnetic Resonance In Medicine 2013, 70: 1748-1760. PMID: 23401099, PMCID: PMC3834165, DOI: 10.1002/mrm.24622.Peer-Reviewed Original ResearchConceptsSuperparamagnetic iron oxideTransverse relaxivityAvailable superparamagnetic iron oxide nanoparticlesIron oxideSuperparamagnetic iron oxide nanoparticlesDrug deliveryHigh transverse relaxivityIron oxide nanoparticlesPolymer matrixEncapsulated iron oxidesMultifunctional nanoparticlesOxide nanoparticlesTheranostic capabilityBiodegradable nanoparticlesNanoparticlesSurface ligandsSurface modificationDiagnostic agentsCellular targetingEncapsulated drugsDual modalityTheranosticsParticle formulationContrast agentsFatty acid ligands
2011
Determining the fate of seeded cells in venous tissue‐engineered vascular grafts using serial MRI
Harrington JK, Chahboune H, Criscione JM, Li AY, Hibino N, Yi T, Villalona GA, Kobsa S, Meijas D, Duncan DR, Devine L, Papademetri X, Shin'oka T, Fahmy TM, Breuer CK. Determining the fate of seeded cells in venous tissue‐engineered vascular grafts using serial MRI. The FASEB Journal 2011, 25: 4150-4161. PMID: 21846838, PMCID: PMC3236630, DOI: 10.1096/fj.11-185140.Peer-Reviewed Original ResearchConceptsTissue-engineered vascular graftsTissue engineering researchSeeded cellsTissue-engineered constructsVascular graftsTissue engineeringImplanted scaffoldIron oxide nanoparticlesOxide nanoparticlesMonitoring techniquesSuperparamagnetic iron oxide nanoparticlesEngineering researchScaffoldsFirst successful applicationSuccessful applicationUltrasmall superparamagnetic iron oxide nanoparticlesRelaxation timeCellular magnetic resonance imagingTransverse relaxation timeVitro OptimizationPrussian blue stainingEngineeringSCID/bg miceNanoparticles
2010
Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD
Leuenroth SJ, Bencivenga N, Chahboune H, Hyder F, Crews CM. Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD. Nephrology Dialysis Transplantation 2010, 25: 2187-2194. PMID: 20139063, PMCID: PMC2902895, DOI: 10.1093/ndt/gfp777.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAntineoplastic Agents, AlkylatingCell ProliferationCyclin-Dependent Kinase Inhibitor p21Disease Models, AnimalDisease ProgressionDiterpenesEpoxy CompoundsGTP-Binding ProteinsIntegrasesKidneyMiceMice, Mutant StrainsMutationMyxovirus Resistance ProteinsPhenanthrenesPolycystic Kidney, Autosomal DominantTime FactorsTRPP Cation ChannelsConceptsAutosomal dominant polycystic kidney diseaseCyst formationModel of ADPKDEnd-stage renal failureBlood urea nitrogen levelsPostnatal days P10Vehicle-treated animalsNumber of microcystsUrea nitrogen levelsDominant polycystic kidney diseaseNumerous rodent modelsInducible mouse modelPolycystic kidney diseaseCystic burdenPkd1-deficient miceRenal functionDrug development studiesRenal failureLiver cystsKidney diseaseDaily injectionsCyst progressionDisease progressionNovel therapiesRodent models
2009
Consequences of Intraventricular Hemorrhage in a Rabbit Pup Model
Chua CO, Chahboune H, Braun A, Dummula K, Chua CE, Yu J, Ungvari Z, Sherbany AA, Hyder F, Ballabh P. Consequences of Intraventricular Hemorrhage in a Rabbit Pup Model. Stroke 2009, 40: 3369-3377. PMID: 19661479, PMCID: PMC2753705, DOI: 10.1161/strokeaha.109.549212.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgingAnimalsAnimals, NewbornBrainCerebral HemorrhageDiffuse Axonal InjuryDiffusion Magnetic Resonance ImagingDisease Models, AnimalGliosisGlycerolHypertrophyLateral VentriclesMicroscopy, Electron, TransmissionMovement DisordersNerve Fibers, MyelinatedPremature BirthRabbitsUltrasonographyConceptsIntraventricular hemorrhageReduced myelinationRabbit pupsPosthemorrhagic ventriculomegalyPremature rabbit pupsPosthemorrhagic hydrocephalusCerebral palsyNeurological consequencesAnimal modelsDevelopment of IVHEvidence of gliosisFocal axonal injuryHours postnatal ageSevere intraventricular hemorrhageLong-term sequelaeWhite matter injuryDiffusion tensor imaging studyHours of ageStandardized animal modelWhite matter volumeWeeks of ageIntraperitoneal glycerolPosthemorrhagic complicationsWestern blot analysisNeurological sequelaeHypoxic Injury during Neonatal Development in Murine Brain: Correlation between In Vivo DTI Findings and Behavioral Assessment
Chahboune H, Ment LR, Stewart WB, Rothman DL, Vaccarino FM, Hyder F, Schwartz ML. Hypoxic Injury during Neonatal Development in Murine Brain: Correlation between In Vivo DTI Findings and Behavioral Assessment. Cerebral Cortex 2009, 19: 2891-2901. PMID: 19380380, PMCID: PMC2774398, DOI: 10.1093/cercor/bhp068.Peer-Reviewed Original ResearchConceptsChronic sublethal hypoxiaLow birth weight preterm infantsBirth weight preterm infantsHypoxia-induced modificationNeonatal rodent modelPreterm birth resultsWeight preterm infantsSignificant neurodevelopmental disabilitiesOpen field taskGreater locomotor activityPreterm infantsPreterm birthNeurodevelopmental consequencesBirth resultsHypoxic injurySomatosensory cortexCaudate putamenCallosal connectivityCorpus callosumBehavioral deficitsNeurodevelopmental disabilitiesRodent modelsNeonatal developmentDTI findingsSublethal hypoxia
2008
Effects of chloramphenicol on brain energy metabolism using 31P spectroscopy: influences on sleep-wake states in rat.
Chahboune H, Mahdjoub R, Desgoutte P, Rousset C, Briguet A, Cespuglio R. Effects of chloramphenicol on brain energy metabolism using 31P spectroscopy: influences on sleep-wake states in rat. Journal Of Neurochemistry 2008, 106: 1552-62. PMID: 18507739, DOI: 10.1111/j.1471-4159.2008.05499.x.Peer-Reviewed Original Research
2007
Neurodevelopment of C57B/L6 mouse brain assessed by in vivo diffusion tensor imaging
Chahboune H, Ment LR, Stewart WB, Ma X, Rothman DL, Hyder F. Neurodevelopment of C57B/L6 mouse brain assessed by in vivo diffusion tensor imaging. NMR In Biomedicine 2007, 20: 375-382. PMID: 17451176, DOI: 10.1002/nbm.1130.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingApparent diffusion coefficientAnterior-posterior directionFractional anisotropyC57B/L6 miceSignificant FA increaseClassical histological findingsVivo diffusion tensorMedial-lateral directionHigh-resolution diffusion tensor imagingWhite matter pathwaysHistological findingsCaudate putamenCorpus callosum
Others
- Selected Book Chapter: H.CHAHBOUNE, P. DESGOUTTE, R. CESPUGLIO, O. FOKAPU, A. BRIGUET. Recording and processing of physiological signal and automatic vigilance state identification. HERMES Science Publications, Instrumentation for physical measurements. volume 2, 389-396, 2001.Peer-Reviewed Original Research
- B Sorli, J F Chateaux, H Chahboune, B Favre, A Briguet and P Morin. Micro-spectrometer for NMR: analysis of small quantities in vitro, Measurments Science and Technology, 15, 877-880, 2004.Peer-Reviewed Original Research
- O. Fokapu, H. Chahboune, M. Armenean, P. Desgoutte, R. Cespuglio, A. Briguet. Denoising EMG and EEG for monitoring small animal models during NMR experiments, IEEE, 2, 1824-1827, 2001.Peer-Reviewed Original Research
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