Guiwu Huang
Associate Research ScientistCards
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Research
Publications
2025
Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss
Fu W, Chen M, Wang K, Chen Y, Cui Y, Xie Y, Lei Z, Hu W, Sun G, Huang G, He C, Fretz J, Hettinghouse A, Liu R, Cai X, Zhang M, Chen Y, Jiang N, He M, Wiznia D, Xu H, Chen Z, Chen L, Tang K, Zhou H, Liu C. Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss. Cell Research 2025, 35: 23-44. PMID: 39743632, PMCID: PMC11701132, DOI: 10.1038/s41422-024-01016-0.Peer-Reviewed Original ResearchConceptsGC-induced osteoporosisBone lossInflammatory arthritisAdverse effects of dexamethasoneGlucocorticoid-induced bone lossHigh-dose dexamethasoneEffect of dexamethasoneFDA-approved drug librarySynthetic GCTreat inflammatory arthritisImmunosuppressive drugsPrescribed anti-inflammatoryGC receptorCombinatorial administrationSide effectsLow affinityGlucocorticoidOsteoporosisDexamethasoneReceptorsAdverse effectsBinding receptorsAnti-inflammatoryDrug libraryTau deficiency
2024
Mendelian randomization analysis separated the independent impact of childhood obesity and adult obesity on socioeconomic status, psychological status, and substance use
Cai J, Zhao L, Li N, Xiao Z, Huang G. Mendelian randomization analysis separated the independent impact of childhood obesity and adult obesity on socioeconomic status, psychological status, and substance use. Heliyon 2024, 10: e36835. PMID: 39263080, PMCID: PMC11388778, DOI: 10.1016/j.heliyon.2024.e36835.Peer-Reviewed Original ResearchAdult body mass indexChildhood body mass indexUnivariable Mendelian randomizationBody mass indexImpact of childhood obesityMultivariable MRPrevent adverse outcomesChildhood obesityHousehold incomeAdult obesitySocioeconomic statusPsychological statusHigher childhood body mass indexMendelian randomization analysisLower household incomeSingle nucleotide polymorphismsWell-beingHigher body mass indexSubstance useAdverse outcomesSubjective well-beingEffects of childhoodImpact of obesityMendelian randomizationRandomization analysisNav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis
Fu W, Vasylyev D, Bi Y, Zhang M, Sun G, Khleborodova A, Huang G, Zhao L, Zhou R, Li Y, Liu S, Cai X, He W, Cui M, Zhao X, Hettinghouse A, Good J, Kim E, Strauss E, Leucht P, Schwarzkopf R, Guo E, Samuels J, Hu W, Attur M, Waxman S, Liu C. Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis. Nature 2024, 625: 557-565. PMID: 38172636, PMCID: PMC10794151, DOI: 10.1038/s41586-023-06888-7.Peer-Reviewed Original ResearchVoltage-gated sodium channelsOA progressionDorsal root ganglion neuronsStructural joint damagePain relief treatmentHuman OA chondrocytesCommon joint diseaseMultiple mouse modelsNav1.7 blockersPain behaviorGanglion neuronsPharmacological blockadeJoint damageJoint degenerationChannel blockersJoint diseaseOA chondrocytesMouse modelTherapeutic targetOsteoarthritisIntracellular Ca2Nav1.7Nav1.7 channelsGenetic ablationLimited evidence
2023
CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis
Wen X, Fang G, Li H, Jiang Z, Du X, Liao Z, Liu R, Huang G, Meng F, Liao W, Zhang Z. CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis. International Journal Of Biological Macromolecules 2023, 256: 128453. PMID: 38016613, DOI: 10.1016/j.ijbiomac.2023.128453.Peer-Reviewed Original ResearchTherapeutic effectCartilage degenerationMesenchymal stem cell therapyLimited treatment optionsIntra-articular injectionMSC therapeutic effectsProinflammatory cytokine mRNADegenerative joint diseaseDMM mouse modelNew therapeutic targetsHigher OARSI scoresStem cell therapyChronic inflammationIL-1βTreatment optionsOARSI scoresJoint diseaseCytokine mRNAMouse modelCombination of MSCTherapeutic targetIL6 mRNAOA cartilageOsteoarthritisInflammation
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