Cell signaling and tissue remodeling in the pulmonary autograft after the Ross procedure: A computational study
Maes L, Vervenne T, Hendrickx A, Estrada A, Van Hoof L, Verbrugghe P, Rega F, Jones E, Humphrey J, Famaey N. Cell signaling and tissue remodeling in the pulmonary autograft after the Ross procedure: A computational study. Journal Of Biomechanics 2024, 171: 112180. PMID: 38906711, DOI: 10.1016/j.jbiomech.2024.112180.Peer-Reviewed Original ResearchRoss procedurePulmonary autograftPatient's pulmonary valveTranscription factorsPulmonary valveSmooth muscleActivation of genesAortic positionRelevant transcription factorsTissue remodelingAutograftExcessive dilatationTranscriptome dataGene activationCell signalingSignaling pathwayTarget genesMultiscale modelGenesTissueCellsFailure mechanismCell-scaleMechanical propertiesCell-scale model