Jay Humphrey, PhD
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Department Chair, Biomedical Engineering
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John C. Malone Professor of Biomedical Engineering
Department Chair, Biomedical EngineeringBiography
Jay Humphrey's research interests involve vascular mechanics and mechanobiology: using genetic, pharmacologic, and surgical models to elucidate mechanisms that underlie diverse vascular diseases; developing theoretical frameworks for understanding vascular disease progression and designing clinical interventions; and using computational models to design and evaluate tissue engineered vascular grafts based on concepts of mechanobiology and immunobiology.
Education & Training
- PhD
- Georgia Institute of Technology (1985)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jay Humphrey's published research.
Publications Timeline
A big-picture view of Jay Humphrey's research output by year.
Edward Manning, MD, PhD
George Tellides, MD, PhD
Martin Schwartz, PhD
Charles Dela Cruz, MD, PhD
Daniel Greif, MD
Inderjit Singh, MBChB, BMedSci, FRCP, FCCP
31Publications
2,345Citations
Publications
Dynamic biaxial loading of vascular smooth muscle cell seeded tissue equivalents
Paukner D, Jennings I, Cyron C, Humphrey J. Dynamic biaxial loading of vascular smooth muscle cell seeded tissue equivalents. Journal Of The Mechanical Behavior Of Biomedical Materials 2024, 157: 106639. PMID: 38970943, DOI: 10.1016/j.jmbbm.2024.106639.Peer-Reviewed Original ResearchConceptsCyclic loadingBiaxial loading conditionsPeriod of cyclic loadingStudy cell-matrix interactionsLoad amplitudeUniaxial experimentsDynamic loadingBiaxial forceCruciform samplesLoading conditionsExternal loadMechanical stateBoundary conditionsLoadExtracellular matrixInfluence cell phenotypeMechanical constraintsRange of forcesCell-matrix interactionsCollagen gelsTissue equivalentsForceSynthetic cellsLoad in vivoVascular smooth muscle cellsStiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodelingCell signaling and tissue remodeling in the pulmonary autograft after the Ross procedure: A computational study
Maes L, Vervenne T, Hendrickx A, Estrada A, Van Hoof L, Verbrugghe P, Rega F, Jones E, Humphrey J, Famaey N. Cell signaling and tissue remodeling in the pulmonary autograft after the Ross procedure: A computational study. Journal Of Biomechanics 2024, 171: 112180. PMID: 38906711, DOI: 10.1016/j.jbiomech.2024.112180.Peer-Reviewed Original ResearchAltmetricConceptsRoss procedurePulmonary autograftPatient's pulmonary valveTranscription factorsPulmonary valveSmooth muscleActivation of genesAortic positionRelevant transcription factorsTissue remodelingAutograftExcessive dilatationTranscriptome dataGene activationCell signalingSignaling pathwayTarget genesMultiscale modelGenesTissueCellsFailure mechanismCell-scaleMechanical propertiesCell-scale modelMultiscale computational model of aortic remodeling following postnatal disruption of TGFβ signaling
Estrada A, Irons L, Tellides G, Humphrey J. Multiscale computational model of aortic remodeling following postnatal disruption of TGFβ signaling. Journal Of Biomechanics 2024, 169: 112152. PMID: 38763809, PMCID: PMC11141772, DOI: 10.1016/j.jbiomech.2024.112152.Peer-Reviewed Original ResearchAltmetricConceptsAdult aortaTGFB signalingSmooth muscle cellsAortic remodelingCardiac-inducedMouse modelNormal mechanical loadingMuscle cellsPostnatal developmentHemodynamic loadNormal loadAortaMechanical homeostasisMechanical loadingMultiscale computational modelIncreasing loadLoadCell signalingGene productsStructural integrityHemodynamics and Wall Mechanics of Vascular Graft Failure
Szafron J, Heng E, Boyd J, Humphrey J, Marsden A. Hemodynamics and Wall Mechanics of Vascular Graft Failure. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 1065-1085. PMID: 38572650, PMCID: PMC11043008, DOI: 10.1161/atvbaha.123.318239.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsVascular graftsTissue-engineered vascular graftsWall mechanicsSolid mechanicsVascular graft failureLoad magnitudeMechanobiological processesLoadMechanobiological stimuliMechanosensitive signaling pathwaysBiomechanical stateWallGraft failureBiomechanical loadingCongenital heart surgeryCoronary artery bypass graftingEnd-organ dysfunctionGraft materialArtery bypass graftingFeedback loopComputational toolsRemodeling of Murine Branch Pulmonary Arteries Under Chronic Hypoxia and Short-Term Normoxic Recovery.
Ramachandra A, Jiang B, Jennings I, Manning E, Humphrey J. Remodeling of Murine Branch Pulmonary Arteries Under Chronic Hypoxia and Short-Term Normoxic Recovery. Journal Of Biomechanical Engineering 2024, 146 PMID: 38421341, DOI: 10.1115/1.4064967.Peer-Reviewed Original ResearchAltmetricConceptsWeeks of hypoxiaBranch pulmonary arteriesWeeks of normoxic recoveryPulmonary arteryEndothelial cell responsesSmooth muscleChronic hypoxiaNormoxic recoveryPulmonary arterial remodelingCell responsesProximal pulmonary arteriesLongitudinal changesHypoxia-induced changesC57BL/6J micePulmonary pathologyThin collagen fibersArterial remodelingBiaxial mechanicsCircumferential stressEnergy storageNormal valuesHypoxiaWeeksVascular adaptationFraction of cytoplasmTissue engineered vascular grafts are resistant to the formation of dystrophic calcification
Turner M, Blum K, Watanabe T, Schwarz E, Nabavinia M, Leland J, Villarreal D, Schwartzman W, Chou T, Baker P, Matsumura G, Krishnamurthy R, Yates A, Hor K, Humphrey J, Marsden A, Stacy M, Shinoka T, Breuer C. Tissue engineered vascular grafts are resistant to the formation of dystrophic calcification. Nature Communications 2024, 15: 2187. PMID: 38467617, PMCID: PMC10928115, DOI: 10.1038/s41467-024-46431-4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTissue-engineered vascular graftsTissue engineered vascular graftsVascular graftsCongenital heart surgeryComputational fluid dynamics simulationsFluid dynamics simulationsPolytetrafluoroethylene graftHeart surgeryDystrophic calcificationRetrospective clinical studyGraft complianceDegree of calcificationClinical studiesProsthetic biomaterialsBiomaterialsAnimal modelsPolytetrafluoroethyleneHemodynamic performanceNatural historyCalcificationGraftOvine modelVascular conduitsLong-term successSurgeryGrand Challenges at the Interface of Engineering and Medicine
Subramaniam S, Akay M, Anastasio M, Bailey V, Boas D, Bonato P, Chilkoti A, Cochran J, Colvin V, Desai T, Duncan J, Epstein F, Fraley S, Giachelli C, Grande-Allen K, Green J, Guo X, Hilton I, Humphrey J, Johnson C, Karniadakis G, King M, Kirsch R, Kumar S, Laurencin C, Li S, Lieber R, Lovell N, Mali P, Margulies S, Meaney D, Ogle B, Palsson B, Peppas N, Perreault E, Rabbitt R, Setton L, Shea L, Shroff S, Shung K, Tolias A, van der Meulen M, Varghese S, Vunjak-Novakovic G, White J, Winslow R, Zhang J, Zhang K, Zukoski C, Miller M. Grand Challenges at the Interface of Engineering and Medicine. IEEE Open Journal Of Engineering In Medicine And Biology 2024, 5: 1-13. PMID: 38415197, PMCID: PMC10896418, DOI: 10.1109/ojemb.2024.3351717.Peer-Reviewed Original ResearchAltmetricCentral Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia
Hopper S, Weiss D, Mikush N, Jiang B, Spronck B, Cavinato C, Humphrey J, Figueroa C. Central Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia. Annals Of Biomedical Engineering 2024, 52: 1051-1066. PMID: 38383871, DOI: 10.1007/s10439-024-03440-0.Peer-Reviewed Original ResearchConceptsEffects of angiotensin II infusionMouse-to-mouse variationAngiotensin II-induced hypertensionRegional vascular structuresII-induced hypertensionAngiotensin II-infused miceAngiotensin II infusionWild-type miceDescending thoracic aortaGroups of miceSuprarenal abdominal aortaEffects of hypertensionCentral arterial stiffnessDepressed hemodynamicsII infusionIndicator of hypertensionSystemic hypertensionRenovascular diseaseCardiac functionInduced hypertensionDistal aortaThoracic aortaEffects of anesthesiaMouse modelAbdominal aortaDevelopmental changes in lung function of mice are independent of sex as a biological variable
Bärnthaler T, Ramachandra A, Ebanks S, Guerrera N, Sharma L, Dela Cruz C, Humphrey J, Manning E. Developmental changes in lung function of mice are independent of sex as a biological variable. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2024, 326: l627-l637. PMID: 38375577, DOI: 10.1152/ajplung.00120.2023.Peer-Reviewed Original ResearchAltmetricConceptsPulmonary function testsWeeks of ageStatic complianceMale miceInspiratory capacityLung functionBody weight-basedHuman lung pathologiesLung function of miceFemale C57BL/6J miceLung function parametersSex-dependent changesFunction of miceMeasures of lung functionIndependent of sexPreclinical modelsFemale miceC57BL/6J miceLung pathologyFunction testsMiceWeight-basedLungLung disease researchWeeks
Academic Achievements and Community Involvement
honor Fellow
International AwardInternational Academy of Medical and Biological EngineeringDetails09/10/2019United Stateshonor Collen-Francqui Chair – Belgium
International AwardGhent University and KU LeuvenDetails09/01/2018Belgiumactivity Member
Professional OrganizationsWorld Council of Biomechanics (2006-2018)Details09/01/2006 - 09/01/2018DescriptionMember, World Council of Biomechanics (2006-2018)honor Doctorate Honoris Causa
International AwardÉcole Nationale Supérieure des MinesDetails09/01/2017Franceactivity Chair
Professional OrganizationsUS National Committee of BiomechanicsDetails09/01/2014 - 09/01/2016DescriptionChair, US National Committee of Biomechanics (2014-2016)
Links & Media
News
- May 12, 2023
Targeting Fibronectin-integrin α5 Signaling in Marfan Syndrome
- April 02, 2020
Why do aortic aneurysms form? Yale-led team finds the reason
- June 14, 2018
New university report recommends science priorities for the decade ahead
- February 12, 2013
Jay Humphrey named to the inaugural John C. Malone Professorship