2024
Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice
Vickers E, McCormick D. Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice. ELife 2024, 13: rp94167. PMID: 38808733, PMCID: PMC11136495, DOI: 10.7554/elife.94167.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCalciumMaleMiceMicroscopy, Fluorescence, MultiphotonNeocortexNeuronsWakefulnessConceptsTask-specific cognitive demandsNeural activityFlow of neural activityTask-dependent behaviorsRegions of cortexCognitive demandsSensory discriminationMouse dorsalCortical areasBehavior primitivesMesoscopic imagingPopulations of neuronsNeural ensemblesLateral neocortexSimultaneous accessImage dataInternal stateNeuron resolutionNeocortexMiceActivation motifNeuronsSpontaneous changesArousalCortex
2021
Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations
Nestvogel D, McCormick D. Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations. Neuron 2021, 110: 120-138.e4. PMID: 34687663, PMCID: PMC8815448, DOI: 10.1016/j.neuron.2021.10.005.Peer-Reviewed Original ResearchConceptsState-dependent activityAlpha-like rhythmVisual thalamusAwake animalsMovement-related activationHz oscillationsPrimary visual cortexLow-threshold CaThalamic neuronsMovement-related signalsIntracellular recordingsThalamocortical cellsThalamocortical mechanismsCell-intrinsic propertiesVisual cortexThalamocortical interactionsBehavioral statesThalamusNeural mechanismsAlpha oscillationsNeuronsDistinct patternsV1Movement signalsRhythm
2015
Waking State: Rapid Variations Modulate Neural and Behavioral Responses
McGinley MJ, Vinck M, Reimer J, Batista-Brito R, Zagha E, Cadwell CR, Tolias AS, Cardin JA, McCormick DA. Waking State: Rapid Variations Modulate Neural and Behavioral Responses. Neuron 2015, 87: 1143-1161. PMID: 26402600, PMCID: PMC4718218, DOI: 10.1016/j.neuron.2015.09.012.Peer-Reviewed Original Research
2005
Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus
Broberger C, McCormick D. Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus. Journal Of Neuroscience 2005, 25: 1664-1673. PMID: 15716402, PMCID: PMC6725920, DOI: 10.1523/jneurosci.3198-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBicucullineCalcium SignalingEpilepsyFemaleFerretsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesIn Vitro TechniquesInterneuronsIon TransportMaleMethacholine ChlorideMuscarinic AgonistsPatch-Clamp TechniquesPotassiumPotassium ChannelsReceptors, GABA-AThalamusThyrotropin-Releasing HormoneWakefulnessConceptsThyrotropin-releasing hormoneThalamocortical cellsApplication of TRHNeuropeptide thyrotropin-releasing hormoneRapid eye movement (REM) sleepRhythmic burst firingAnti-epileptic effectsEye movement sleepApplication of bicucullineLateral geniculate nucleusSlow-wave sleepThalamocortical network activityAction potential generationSingle-spike modeNonspecific currentsPerigeniculate neuronsExcitatory effectsGABAergic neuronsMovement sleepPGN neuronsBath applicationBurst firingGeniculate nucleusIntracellular recordingsDirect depolarization
1993
Chapter 36: Actions of acetylcholine in the cerebral cortex and thalamus and implications for function
McCormick D. Chapter 36: Actions of acetylcholine in the cerebral cortex and thalamus and implications for function. Progress In Brain Research 1993, 98: 303-308. PMID: 8248519, DOI: 10.1016/s0079-6123(08)62412-7.Peer-Reviewed Original ResearchConceptsCholinergic neuronsCerebral cortexNicotinic receptorsForebrain activityAction of acetylcholinePost-synaptic responsesAbnormal neuronal functionNicotinic typeCholinergic pathwaysBasal forebrainCholinergic receptorsMuscarinic receptorsCholinergic systemMammalian CNSPhasic responseModulatory controlNeuronal functionAlzheimer's diseaseDistinct subtypesReceptor activationProlonged inhibitionFiring patternsPharmacological propertiesAcetylcholineProlonged changes