Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current
Pape H, McCormick D. Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current. Nature 1989, 340: 715-718. PMID: 2475782, DOI: 10.1038/340715a0.Peer-Reviewed Original ResearchConceptsThalamic neuronsRhythmic burstsAction potentialsHyperpolarization-activated cation currentSingle spike activityGenerate action potentialsSlow-wave sleepSingle-spike firingState of excitabilityAction potential generationSerotonergic inputNeurons displaySynaptic processingSpike activityCation currentThalamic burstsSpike firingNoradrenalineSerotoninCellular mechanismsNeuronsRhythmic oscillationsNovel actionBehavioral statesCyclic AMPCholinergic and noradrenergic modulation of thalamocortical processing
McCormick D. Cholinergic and noradrenergic modulation of thalamocortical processing. Trends In Neurosciences 1989, 12: 215-221. PMID: 2473557, DOI: 10.1016/0166-2236(89)90125-2.Peer-Reviewed Original ResearchConceptsThalamocortical processingPeriods of drowsinessState of excitabilityModulatory neurotransmitter systemsNeuronal responsivenessNoradrenergic componentThalamocortical rhythmsCortical neuronsNeurotransmitter systemsNoradrenergic modulationSynaptic inputsNeuronal activityPotassium currentSynchronized sleepMarked increaseRhythmic oscillationsRhythmNorepinephrineAcetylcholineExcitabilitySleepNeuronsDrowsiness