1999
Modulation of a pacemaker current through Ca2+-induced stimulation of cAMP production
Lüthi A, McCormick D. Modulation of a pacemaker current through Ca2+-induced stimulation of cAMP production. Nature Neuroscience 1999, 2: 634-641. PMID: 10404196, DOI: 10.1038/10189.Peer-Reviewed Original ResearchConceptsHyperpolarization-activated cation currentIh activationThalamocortical rhythmsThalamocortical activityCation currentNeuronal propertiesPacemaker currentCAMP productionPersistent activationProlonged changesProlonged activationBrief increaseDependent modulationSlow recurrenceActivationSubsequent productionCa2RecurrenceModulation
1998
Periodicity of Thalamic Spindle Waves Is Abolished by ZD7288,a Blocker of I h
Lüthi A, Bal T, McCormick D. Periodicity of Thalamic Spindle Waves Is Abolished by ZD7288,a Blocker of I h. Journal Of Neurophysiology 1998, 79: 3284-3289. PMID: 9636128, DOI: 10.1152/jn.1998.79.6.3284.Peer-Reviewed Original ResearchConceptsSpindle wavesHyperpolarization-activated cation current IhCurrent-clamp recordingsIntracellular recording techniquesBlock of IhVoltage-clamp recordingsRebound burstsThalamic activityRefractory periodPacemaker currentLocal applicationZD7288AfterdepolarizationsCurrent IhRecording techniquesRepetitive hyperpolarizationNetwork activityHyperpolarizationSlow rhythmicityFurther supportIH
1992
Chapter 10 Determination of State-Dependent Processing in Thalamus by Single Neuron Properties and Neuromodulators
MCCORMICK D, STROWBRIDGE B, HUGUENARD J. Chapter 10 Determination of State-Dependent Processing in Thalamus by Single Neuron Properties and Neuromodulators. 1992, 259-290. DOI: 10.1016/b978-0-12-484815-3.50017-7.Peer-Reviewed Original ResearchState-dependent processingRelay neuronsSingle neuron propertiesHyperpolarization-activated cation currentNeuron propertiesThalamic relay neuronsAction potential generationThalamic neuronsCentral neuronsRhythmic burstsNervous systemCation currentSynaptic connectionsPacemaker currentThalamusNeuronsMotor informationPotential generationNeuromodulatorsFunctional consequences